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Protein

TLR4 interactor with leucine rich repeats

Gene

Tril

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion and the inflammatory response (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
TLR4 interactor with leucine rich repeats
Alternative name(s):
Leucine-rich repeat-containing protein KIAA0644 homolog
Gene namesi
Name:Tril
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1310827. Tril.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 696ExtracellularSequence analysisAdd BLAST671
Transmembranei697 – 717HelicalSequence analysisAdd BLAST21
Topological domaini718 – 809CytoplasmicSequence analysisAdd BLAST92

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000034925726 – 811TLR4 interactor with leucine rich repeatsAdd BLAST786

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Glycosylationi411N-linked (GlcNAc...)Sequence analysis1
Glycosylationi589N-linked (GlcNAc...)Sequence analysis1
Modified residuei798PhosphoserineCombined sources1

Post-translational modificationi

N-glycolysaled.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ496Z2.
PRIDEiQ496Z2.

PTM databases

iPTMnetiQ496Z2.
PhosphoSitePlusiQ496Z2.

Expressioni

Tissue specificityi

Highly expressed in cortical astrocytes and in cerebellar granule neurons.1 Publication

Gene expression databases

BgeeiENSRNOG00000026941.
GenevisibleiQ496Z2. RN.

Interactioni

Subunit structurei

Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4. Interacts with TLR4; this interaction is greatly enhanced following LPS stimulation (By similarity). Interacts with LPS (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037327.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 57LRRNTAdd BLAST32
Repeati61 – 81LRR 1Add BLAST21
Repeati84 – 105LRR 2Add BLAST22
Repeati108 – 129LRR 3Add BLAST22
Repeati132 – 153LRR 4Add BLAST22
Repeati156 – 177LRR 5Add BLAST22
Repeati180 – 201LRR 6Add BLAST22
Repeati204 – 223LRR 7Add BLAST20
Repeati230 – 251LRR 8Add BLAST22
Repeati254 – 275LRR 9Add BLAST22
Repeati278 – 298LRR 10Add BLAST21
Repeati302 – 323LRR 11Add BLAST22
Repeati326 – 347LRR 12Add BLAST22
Domaini359 – 416LRRCTAdd BLAST58

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOVERGENiHBG066060.
InParanoidiQ496Z2.
OMAiEFPCDRF.
OrthoDBiEOG091G02AN.
PhylomeDBiQ496Z2.
TreeFamiTF331598.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
PF01463. LRRCT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q496Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGVGAVRFW LVVCGCLAFP PRAESVCPER CDCQHPQHLL CTNRGLRAVP
60 70 80 90 100
KTSSLPSPQD VLTYSLGGNF ITNITAFDFH RLGQLRRLDL QYNQIRSLHP
110 120 130 140 150
KTFEKLSRLE ELYLGNNLLQ ALAPGTLAPL RKLRILYANG NEIGRLSRGS
160 170 180 190 200
FEGLESLVKL RLDGNVLGAL PDAVFAPLGN LLYLHLEANR IRFLGKNAFT
210 220 230 240 250
QLGKLRFLNL SANELQPSLR HAATFVPLRS LSTLILSANS LQHLGPRVFQ
260 270 280 290 300
HLPRLGLLSL SGNQLTHLAP EAFWGLEALR ELRLEGNRLN QLPLTLLEPL
310 320 330 340 350
HSLEALDLSG NELSALHPAT FGHQGRLREL SLRDNALSAL SGDIFAASPA
360 370 380 390 400
LYRLDLDGNG WTCDCRLRGL KRWMGNWHSQ GRLLTVFVQC RHPPALRGKY
410 420 430 440 450
LDYLDDQLLQ NGSCVDPSPS PTAGSRQWPI STAPGEGMTP PAGLAQELPL
460 470 480 490 500
QPQPQPQQRG RLLPGVAWAG AAKELVGNRS ALRLNRRGPG LQHQSPSAAA
510 520 530 540 550
ASGSAPQSLD LHEKPERGRP TRANLPQTEP TPTSEPASGT PSARDSWQRA
560 570 580 590 600
AKQRLASEQQ GRAVQYDSGV GLPPLVSDPC DFNKFILCNL TVEAVSANSA
610 620 630 640 650
SVRWAVREHR SPRPQGGARF RLLFDRFGQQ PKFQRFVYLP ERSDSATLHE
660 670 680 690 700
LRGDTPYLVC VEGVLGGRVC PVAPRDHCAG LVTLPEAGGR GGVDYQLLTL
710 720 730 740 750
VLLAINALLV LLALAAWGSR WLRRKLRARR KGGAPVHVRH MYSTRRPLRS
760 770 780 790 800
MGTGVSADFS GFQSHRPRTT VCALSEADLI EFPCDRFMDS SGGGTGGSLR
810
REDHLLQRFA D
Length:811
Mass (Da):89,053
Last modified:September 13, 2005 - v1
Checksum:i2913EFA8BBFBB355
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100659 mRNA. Translation: AAI00660.1.
RefSeqiNP_001029182.1. NM_001034010.1.
UniGeneiRn.25045.

Genome annotation databases

EnsembliENSRNOT00000036951; ENSRNOP00000037327; ENSRNOG00000026941.
GeneIDi362364.
KEGGirno:362364.
UCSCiRGD:1310827. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100659 mRNA. Translation: AAI00660.1.
RefSeqiNP_001029182.1. NM_001034010.1.
UniGeneiRn.25045.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037327.

PTM databases

iPTMnetiQ496Z2.
PhosphoSitePlusiQ496Z2.

Proteomic databases

PaxDbiQ496Z2.
PRIDEiQ496Z2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036951; ENSRNOP00000037327; ENSRNOG00000026941.
GeneIDi362364.
KEGGirno:362364.
UCSCiRGD:1310827. rat.

Organism-specific databases

CTDi9865.
RGDi1310827. Tril.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOVERGENiHBG066060.
InParanoidiQ496Z2.
OMAiEFPCDRF.
OrthoDBiEOG091G02AN.
PhylomeDBiQ496Z2.
TreeFamiTF331598.

Miscellaneous databases

PROiQ496Z2.

Gene expression databases

BgeeiENSRNOG00000026941.
GenevisibleiQ496Z2. RN.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
PF01463. LRRCT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRIL_RAT
AccessioniPrimary (citable) accession number: Q496Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 13, 2005
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.