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Protein

TLR4 interactor with leucine rich repeats

Gene

Tril

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion and the inflammatory response (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
TLR4 interactor with leucine rich repeats
Alternative name(s):
Leucine-rich repeat-containing protein KIAA0644 homolog
Gene namesi
Name:Tril
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1310827. Tril.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 696671ExtracellularSequence analysisAdd
BLAST
Transmembranei697 – 71721HelicalSequence analysisAdd
BLAST
Topological domaini718 – 80992CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 811786TLR4 interactor with leucine rich repeatsPRO_0000349257Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence analysis
Glycosylationi411 – 4111N-linked (GlcNAc...)Sequence analysis
Glycosylationi589 – 5891N-linked (GlcNAc...)Sequence analysis
Modified residuei798 – 7981PhosphoserineCombined sources

Post-translational modificationi

N-glycolysaled.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ496Z2.
PRIDEiQ496Z2.

PTM databases

iPTMnetiQ496Z2.

Expressioni

Tissue specificityi

Highly expressed in cortical astrocytes and in cerebellar granule neurons.1 Publication

Gene expression databases

GenevisibleiQ496Z2. RN.

Interactioni

Subunit structurei

Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4. Interacts with TLR4; this interaction is greatly enhanced following LPS stimulation (By similarity). Interacts with LPS (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037327.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 5732LRRNTAdd
BLAST
Repeati61 – 8121LRR 1Add
BLAST
Repeati84 – 10522LRR 2Add
BLAST
Repeati108 – 12922LRR 3Add
BLAST
Repeati132 – 15322LRR 4Add
BLAST
Repeati156 – 17722LRR 5Add
BLAST
Repeati180 – 20122LRR 6Add
BLAST
Repeati204 – 22320LRR 7Add
BLAST
Repeati230 – 25122LRR 8Add
BLAST
Repeati254 – 27522LRR 9Add
BLAST
Repeati278 – 29821LRR 10Add
BLAST
Repeati302 – 32322LRR 11Add
BLAST
Repeati326 – 34722LRR 12Add
BLAST
Domaini359 – 41658LRRCTAdd
BLAST

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOVERGENiHBG066060.
InParanoidiQ496Z2.
OMAiEFPCDRF.
OrthoDBiEOG7NCV2T.
PhylomeDBiQ496Z2.
TreeFamiTF331598.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
PF01463. LRRCT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q496Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGVGAVRFW LVVCGCLAFP PRAESVCPER CDCQHPQHLL CTNRGLRAVP
60 70 80 90 100
KTSSLPSPQD VLTYSLGGNF ITNITAFDFH RLGQLRRLDL QYNQIRSLHP
110 120 130 140 150
KTFEKLSRLE ELYLGNNLLQ ALAPGTLAPL RKLRILYANG NEIGRLSRGS
160 170 180 190 200
FEGLESLVKL RLDGNVLGAL PDAVFAPLGN LLYLHLEANR IRFLGKNAFT
210 220 230 240 250
QLGKLRFLNL SANELQPSLR HAATFVPLRS LSTLILSANS LQHLGPRVFQ
260 270 280 290 300
HLPRLGLLSL SGNQLTHLAP EAFWGLEALR ELRLEGNRLN QLPLTLLEPL
310 320 330 340 350
HSLEALDLSG NELSALHPAT FGHQGRLREL SLRDNALSAL SGDIFAASPA
360 370 380 390 400
LYRLDLDGNG WTCDCRLRGL KRWMGNWHSQ GRLLTVFVQC RHPPALRGKY
410 420 430 440 450
LDYLDDQLLQ NGSCVDPSPS PTAGSRQWPI STAPGEGMTP PAGLAQELPL
460 470 480 490 500
QPQPQPQQRG RLLPGVAWAG AAKELVGNRS ALRLNRRGPG LQHQSPSAAA
510 520 530 540 550
ASGSAPQSLD LHEKPERGRP TRANLPQTEP TPTSEPASGT PSARDSWQRA
560 570 580 590 600
AKQRLASEQQ GRAVQYDSGV GLPPLVSDPC DFNKFILCNL TVEAVSANSA
610 620 630 640 650
SVRWAVREHR SPRPQGGARF RLLFDRFGQQ PKFQRFVYLP ERSDSATLHE
660 670 680 690 700
LRGDTPYLVC VEGVLGGRVC PVAPRDHCAG LVTLPEAGGR GGVDYQLLTL
710 720 730 740 750
VLLAINALLV LLALAAWGSR WLRRKLRARR KGGAPVHVRH MYSTRRPLRS
760 770 780 790 800
MGTGVSADFS GFQSHRPRTT VCALSEADLI EFPCDRFMDS SGGGTGGSLR
810
REDHLLQRFA D
Length:811
Mass (Da):89,053
Last modified:September 13, 2005 - v1
Checksum:i2913EFA8BBFBB355
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100659 mRNA. Translation: AAI00660.1.
RefSeqiNP_001029182.1. NM_001034010.1.
UniGeneiRn.25045.

Genome annotation databases

EnsembliENSRNOT00000036951; ENSRNOP00000037327; ENSRNOG00000026941.
GeneIDi362364.
KEGGirno:362364.
UCSCiRGD:1310827. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100659 mRNA. Translation: AAI00660.1.
RefSeqiNP_001029182.1. NM_001034010.1.
UniGeneiRn.25045.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037327.

PTM databases

iPTMnetiQ496Z2.

Proteomic databases

PaxDbiQ496Z2.
PRIDEiQ496Z2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036951; ENSRNOP00000037327; ENSRNOG00000026941.
GeneIDi362364.
KEGGirno:362364.
UCSCiRGD:1310827. rat.

Organism-specific databases

CTDi9865.
RGDi1310827. Tril.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOVERGENiHBG066060.
InParanoidiQ496Z2.
OMAiEFPCDRF.
OrthoDBiEOG7NCV2T.
PhylomeDBiQ496Z2.
TreeFamiTF331598.

Miscellaneous databases

PROiQ496Z2.

Gene expression databases

GenevisibleiQ496Z2. RN.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
PF01463. LRRCT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  2. Cited for: TISSUE SPECIFICITY.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-798, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTRIL_RAT
AccessioniPrimary (citable) accession number: Q496Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 13, 2005
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.