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Protein

Elongator complex protein 2

Gene

Elp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the ligand-dependent activation of STAT3.By similarity
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 2
Short name:
ELP2
Alternative name(s):
SHINC-2
STAT3-interacting protein 1
Short name:
StIP1
Gene namesi
Name:Elp2
Synonyms:Statip1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1306419. Elp2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512431 – 821Elongator complex protein 2Add BLAST821

Proteomic databases

PaxDbiQ496Z0.
PRIDEiQ496Z0.

PTM databases

iPTMnetiQ496Z0.
PhosphoSitePlusiQ496Z0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015301.
GenevisibleiQ496Z0. RN.

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with STAT3 and JAKs (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020601.

Structurei

3D structure databases

ProteinModelPortaliQ496Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati56 – 100WD 1Add BLAST45
Repeati105 – 152WD 2Add BLAST48
Repeati160 – 200WD 3Add BLAST41
Repeati205 – 246WD 4Add BLAST42
Repeati280 – 328WD 5Add BLAST49
Repeati338 – 377WD 6Add BLAST40
Repeati385 – 424WD 7Add BLAST40
Repeati435 – 473WD 8Add BLAST39
Repeati563 – 607WD 9Add BLAST45
Repeati610 – 649WD 10Add BLAST40
Repeati665 – 704WD 11Add BLAST40
Repeati716 – 760WD 12Add BLAST45
Repeati773 – 821WD 13Add BLAST49

Sequence similaritiesi

Belongs to the WD repeat ELP2 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1063. Eukaryota.
ENOG410XRF0. LUCA.
GeneTreeiENSGT00390000000916.
HOGENOMiHOG000200623.
HOVERGENiHBG087208.
InParanoidiQ496Z0.
KOiK11374.
OMAiLHLWKQN.
OrthoDBiEOG091G02XJ.
PhylomeDBiQ496Z0.
TreeFamiTF105985.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiView protein in InterPro
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 5 hits.
SMARTiView protein in SMART
SM00320. WD40. 12 hits.
SUPFAMiSSF50978. SSF50978. 7 hits.
PROSITEiView protein in PROSITE
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 2 hits.

Sequencei

Sequence statusi: Complete.

Q496Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSVLEVSY VFCCPNRARG ALSWNSGPGG LLAFGTSCSV VLYDPQKKVV
60 70 80 90 100
ITNLNGHTAR VNCLHWIRTE DGSPSTELVS GASDNRVIHW ELENNQVLKS
110 120 130 140 150
VRLQGHEGPV YAVHGIYQSG PSDGEQHALI ASAASDSTVR LWSKKGSEVK
160 170 180 190 200
CLQILKFGDG FVLTVCLSTL PDTDAPVLAC GDDGGRIHLF VQQDDWFQKM
210 220 230 240 250
LSLCGHEDWI RGVEWATFGR DLFLASCSQD CLIRIWRLYM KPTSLETEDG
260 270 280 290 300
SIRLKENTFT IKDGGVSTTV AVILETVLAG HENWVNAIHW QPSFYKDGVL
310 320 330 340 350
HQPVRLLSAS MDKTMILWAP DEESGVWLEQ VRVGEVGGNT LGFYGCQFGE
360 370 380 390 400
NGSMIIAHAF HGAMHLWKQS TVNPRQWAPE IVISGHFDGV QDLIWDPEGE
410 420 430 440 450
FIITTSTDQT TRLFAPWKKK NQSQVTWHEI ARPQIHGYNL KCLAMIDRFQ
460 470 480 490 500
FVSGADEKVL RVFSAPRNFV ENFSVISRQS LSHMLYDEDN DLPEGATVPA
510 520 530 540 550
LGLSNKAVFE GDMTYLTSEE EELLSPAFGY PQVIFQPAVL SEPPTEDHLL
560 570 580 590 600
QNTLWPEVQK LYGHGYEIFC VTCNNSKTLL ASACKAAQKE HAAIILWSTT
610 620 630 640 650
SWKQVQSLAY HTLTVTQMAF SPDDKFLLAV SRDRTWSLWK RQDVTSAEFD
660 670 680 690 700
PFFSLFAFTN KITSVHSRII WSCDWSPDSK YFFTGSRDKK VVVWGECNSS
710 720 730 740 750
YNPMEHPINP CSSILDVGSC VTAVSVCPVL NPAQRYIVAV GLESGKICIY
760 770 780 790 800
SWSKTNQETK DWTSCVETTP SQSHTLGIRR LCWKSCSGST EQSEEGTEWL
810 820
DFASCGEDHT VKIYRVNRCA L
Length:821
Mass (Da):91,746
Last modified:September 13, 2005 - v1
Checksum:iEF93996212B557CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092606 mRNA. Translation: AAH92606.1.
BC100661 mRNA. Translation: AAI00662.1.
RefSeqiNP_001029317.1. NM_001034145.1.
UniGeneiRn.25007.

Genome annotation databases

EnsembliENSRNOT00000020601; ENSRNOP00000020601; ENSRNOG00000015301.
GeneIDi307545.
KEGGirno:307545.
UCSCiRGD:1306419. rat.

Similar proteinsi

Entry informationi

Entry nameiELP2_RAT
AccessioniPrimary (citable) accession number: Q496Z0
Secondary accession number(s): Q562B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 13, 2005
Last modified: June 7, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families