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Protein

LON peptidase N-terminal domain and RING finger protein 3

Gene

LONRF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 196RING-type 1PROSITE-ProRule annotationAdd BLAST39
Zinc fingeri467 – 505RING-type 2PROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LON peptidase N-terminal domain and RING finger protein 3
Alternative name(s):
RING finger protein 127
Gene namesi
Name:LONRF3
Synonyms:RNF127
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:21152. LONRF3.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175556.
PharmGKBiPA134900980.

Polymorphism and mutation databases

BioMutaiLONRF3.
DMDMi121949074.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002776711 – 759LON peptidase N-terminal domain and RING finger protein 3Add BLAST759

Proteomic databases

EPDiQ496Y0.
MaxQBiQ496Y0.
PaxDbiQ496Y0.
PeptideAtlasiQ496Y0.
PRIDEiQ496Y0.

PTM databases

iPTMnetiQ496Y0.
PhosphoSitePlusiQ496Y0.

Expressioni

Gene expression databases

BgeeiENSG00000175556.
CleanExiHS_LONRF3.
ExpressionAtlasiQ496Y0. baseline and differential.
GenevisibleiQ496Y0. HS.

Organism-specific databases

HPAiHPA050422.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-2690768,EBI-743771
NOTCH2NLQ7Z3S93EBI-2690768,EBI-945833
PHBP352322EBI-2690768,EBI-354213

Protein-protein interaction databases

BioGridi122927. 6 interactors.
IntActiQ496Y0. 7 interactors.
STRINGi9606.ENSP00000360690.

Structurei

3D structure databases

ProteinModelPortaliQ496Y0.
SMRiQ496Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati67 – 100TPR 1Add BLAST34
Repeati243 – 276TPR 2Add BLAST34
Repeati278 – 310TPR 3Add BLAST33
Repeati312 – 344TPR 4Add BLAST33
Domaini553 – 753Lon N-terminalPROSITE-ProRule annotationAdd BLAST201

Sequence similaritiesi

Contains 1 Lon N-terminal domain.PROSITE-ProRule annotation
Contains 2 RING-type zinc fingers.PROSITE-ProRule annotation
Contains 4 TPR repeats.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 196RING-type 1PROSITE-ProRule annotationAdd BLAST39
Zinc fingeri467 – 505RING-type 2PROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
KOG4159. Eukaryota.
COG2802. LUCA.
GeneTreeiENSGT00440000033329.
HOGENOMiHOG000060199.
HOVERGENiHBG081924.
InParanoidiQ496Y0.
OMAiGCLLEIR.
OrthoDBiEOG091G050D.
PhylomeDBiQ496Y0.
TreeFamiTF327043.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.30.40.10. 2 hits.
InterProiIPR003111. LON_substr-bd_dom.
IPR015947. PUA-like_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF02190. LON_substr_bdg. 1 hit.
[Graphical view]
SMARTiSM00464. LON. 1 hit.
SM00184. RING. 2 hits.
SM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF88697. SSF88697. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
PS00518. ZF_RING_1. 2 hits.
PS50089. ZF_RING_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q496Y0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESVRIEQML SLPAEVSSDN LESAERGASA AQVDMGPHPK VAAEGPAPLP
60 70 80 90 100
TREPEQEQSP GTSTPESKVL LTQADALASR GRIREALEVY RQLSERQQLV
110 120 130 140 150
AEQLEQLVRC LAEKVPQGEA LAPAPPDEGS TASGTVAAEE TGAAAAAAAT
160 170 180 190 200
EVWDGFKCRK CHGFLSDPVS LSCGHTFCKL CLERGRAADR RCALCGVKLS
210 220 230 240 250
ALMVATGRAR GARRAGQQPP PPLRVNVVLS GLLGKLFPGP ARASQLRHEG
260 270 280 290 300
NRLYRERQVE AALLKYNEAV KLAPNDHLLY SNRSQIYFTL ESHENALHDA
310 320 330 340 350
EIACKLRPMG FKAHFRKAQA LATLGKVEEA LREFLYCVSL DGKNKRARCE
360 370 380 390 400
AQRDNLELPH CSSQEEAAAR GDGSSLMDPA KVKGDGQQHH MKDQEEEEEK
410 420 430 440 450
WDATSPKAAS SKTGKCQEKK RKHCQIESQE ETGMPNKASK QDPPTDQGDK
460 470 480 490 500
PALSLPLASF DASDLECALC MRLFYEPVTT PCGHTFCLKC LERCLDHNAK
510 520 530 540 550
CPLCKDGLSQ CLASRKYSKN VIMEELIAKF LPEELKERRK LYEEEMEELS
560 570 580 590 600
NLNKNVPIFV CTMAYPTVPC PLHIFEPCYR LMIRRCIETG TRQFGMCLGD
610 620 630 640 650
PVKGFAEYGC ILEIRNVQFF ADGRSVVDSI GKRRFRVLHQ SQRDGYNTAD
660 670 680 690 700
IEYIEDQKVQ GEDCAELMGL HNCVYQQASL WFHSLKLSLK NRILNHFGPM
710 720 730 740 750
PEKDADPQMN PNGPAWCWWM LAVLPLESRA QLPFLAMRSL KDRLNGIRRV

LAFISRNQN
Length:759
Mass (Da):84,490
Last modified:September 13, 2005 - v1
Checksum:i364C5624DF440296
GO
Isoform 2 (identifier: Q496Y0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-353: Missing.

Show »
Length:718
Mass (Da):79,829
Checksum:i15087DCC0B65A1CA
GO
Isoform 3 (identifier: Q496Y0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     605-610: FAEYGC → HCLLCN
     611-759: Missing.

Show »
Length:610
Mass (Da):67,209
Checksum:i7716365A5D500D1F
GO

Sequence cautioni

The sequence BAB15419 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035954122A → G in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs61730253dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023080313 – 353Missing in isoform 2. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_023081605 – 610FAEYGC → HCLLCN in isoform 3. 1 Publication6
Alternative sequenceiVSP_023082611 – 759Missing in isoform 3. 1 PublicationAdd BLAST149

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026265 mRNA. Translation: BAB15419.1. Different initiation.
AK091777 mRNA. Translation: BAC03744.1.
AL772284 Genomic DNA. Translation: CAI41519.1.
BC099847 mRNA. Translation: AAH99847.1.
BC100671 mRNA. Translation: AAI00672.1.
BC103491 mRNA. Translation: AAI03492.1.
CCDSiCCDS14575.1. [Q496Y0-2]
CCDS35374.1. [Q496Y0-1]
RefSeqiNP_001027026.1. NM_001031855.2. [Q496Y0-1]
NP_079054.3. NM_024778.5. [Q496Y0-2]
UniGeneiHs.144266.

Genome annotation databases

EnsembliENST00000304778; ENSP00000307732; ENSG00000175556. [Q496Y0-2]
ENST00000371628; ENSP00000360690; ENSG00000175556. [Q496Y0-1]
ENST00000481285; ENSP00000435426; ENSG00000175556. [Q496Y0-3]
GeneIDi79836.
KEGGihsa:79836.
UCSCiuc004eqw.5. human. [Q496Y0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026265 mRNA. Translation: BAB15419.1. Different initiation.
AK091777 mRNA. Translation: BAC03744.1.
AL772284 Genomic DNA. Translation: CAI41519.1.
BC099847 mRNA. Translation: AAH99847.1.
BC100671 mRNA. Translation: AAI00672.1.
BC103491 mRNA. Translation: AAI03492.1.
CCDSiCCDS14575.1. [Q496Y0-2]
CCDS35374.1. [Q496Y0-1]
RefSeqiNP_001027026.1. NM_001031855.2. [Q496Y0-1]
NP_079054.3. NM_024778.5. [Q496Y0-2]
UniGeneiHs.144266.

3D structure databases

ProteinModelPortaliQ496Y0.
SMRiQ496Y0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122927. 6 interactors.
IntActiQ496Y0. 7 interactors.
STRINGi9606.ENSP00000360690.

PTM databases

iPTMnetiQ496Y0.
PhosphoSitePlusiQ496Y0.

Polymorphism and mutation databases

BioMutaiLONRF3.
DMDMi121949074.

Proteomic databases

EPDiQ496Y0.
MaxQBiQ496Y0.
PaxDbiQ496Y0.
PeptideAtlasiQ496Y0.
PRIDEiQ496Y0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304778; ENSP00000307732; ENSG00000175556. [Q496Y0-2]
ENST00000371628; ENSP00000360690; ENSG00000175556. [Q496Y0-1]
ENST00000481285; ENSP00000435426; ENSG00000175556. [Q496Y0-3]
GeneIDi79836.
KEGGihsa:79836.
UCSCiuc004eqw.5. human. [Q496Y0-1]

Organism-specific databases

CTDi79836.
GeneCardsiLONRF3.
HGNCiHGNC:21152. LONRF3.
HPAiHPA050422.
neXtProtiNX_Q496Y0.
OpenTargetsiENSG00000175556.
PharmGKBiPA134900980.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
KOG4159. Eukaryota.
COG2802. LUCA.
GeneTreeiENSGT00440000033329.
HOGENOMiHOG000060199.
HOVERGENiHBG081924.
InParanoidiQ496Y0.
OMAiGCLLEIR.
OrthoDBiEOG091G050D.
PhylomeDBiQ496Y0.
TreeFamiTF327043.

Miscellaneous databases

GenomeRNAii79836.
PROiQ496Y0.

Gene expression databases

BgeeiENSG00000175556.
CleanExiHS_LONRF3.
ExpressionAtlasiQ496Y0. baseline and differential.
GenevisibleiQ496Y0. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.30.40.10. 2 hits.
InterProiIPR003111. LON_substr-bd_dom.
IPR015947. PUA-like_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF02190. LON_substr_bdg. 1 hit.
[Graphical view]
SMARTiSM00464. LON. 1 hit.
SM00184. RING. 2 hits.
SM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF88697. SSF88697. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
PS00518. ZF_RING_1. 2 hits.
PS50089. ZF_RING_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLONF3_HUMAN
AccessioniPrimary (citable) accession number: Q496Y0
Secondary accession number(s): Q5JPN6, Q8NB00, Q9H647
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: September 13, 2005
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.