ID   PLK5_HUMAN              Reviewed;         336 AA.
AC   Q496M5; B3KNR4; Q1ZYM0;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 4.
DT   27-MAR-2024, entry version 140.
DE   RecName: Full=Inactive serine/threonine-protein kinase PLK5;
DE   AltName: Full=Polo-like kinase 5;
DE            Short=PLK-5;
GN   Name=PLK5; Synonyms=PLK5P; ORFNames=FG060302;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Cerebellum;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA   Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Liang M., Tang Z.,
RA   Huang B., Lin L., Yang S.;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION, INDUCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=21245385; DOI=10.1128/mcb.00607-10;
RA   de Carcer G., Escobar B., Higuero A.M., Garcia L., Anson A., Perez G.,
RA   Mollejo M., Manning G., Melendez B., Abad-Rodriguez J., Malumbres M.;
RT   "Plk5, a polo box domain-only protein with specific roles in neuron
RT   differentiation and glioblastoma suppression.";
RL   Mol. Cell. Biol. 31:1225-1239(2011).
CC   -!- FUNCTION: Inactive serine/threonine-protein kinase that plays a role in
CC       cell cycle progression and neuronal differentiation.
CC       {ECO:0000269|PubMed:21245385}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cytoplasm
CC       {ECO:0000269|PubMed:21245385}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q496M5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q496M5-2; Sequence=VSP_023654;
CC   -!- TISSUE SPECIFICITY: Expressed in the brain, neurons and glial cells.
CC       Also expressed in highly differentiated cells, such as the serous acini
CC       in the parotid gland, distal and proximal tubules of the kidney,
CC       tubules of the seminal gland, Kupffer cells and some hepatocytes in the
CC       liver, and some cells in the germinal center of lymph nodes (at protein
CC       level). {ECO:0000269|PubMed:21245385}.
CC   -!- INDUCTION: Down-regulated in primary brain tumors.
CC       {ECO:0000269|PubMed:21245385}.
CC   -!- DOMAIN: The truncated protein kinase domain is predicted to be
CC       catalytically inactive; has lost the main activatory
CC       autophosphorylation site and the conserved key residues involved in
CC       phospho-substrate. The C-terminal region (containing the POLO box
CC       domain) is sufficient for inducing cell cycle arrest.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC       kinase family. CDC5/Polo subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00159}.
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DR   EMBL; AK054808; BAG51426.1; -; mRNA.
DR   EMBL; DQ424898; ABD83663.1; -; mRNA.
DR   EMBL; AC027307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC100791; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS59328.1; -. [Q496M5-1]
DR   RefSeq; NP_001230008.1; NM_001243079.1. [Q496M5-1]
DR   AlphaFoldDB; Q496M5; -.
DR   SMR; Q496M5; -.
DR   BioGRID; 125996; 1.
DR   STRING; 9606.ENSP00000468376; -.
DR   PhosphoSitePlus; Q496M5; -.
DR   BioMuta; PLK5; -.
DR   DMDM; 308153664; -.
DR   PaxDb; 9606-ENSP00000466248; -.
DR   PeptideAtlas; Q496M5; -.
DR   Antibodypedia; 64895; 199 antibodies from 29 providers.
DR   DNASU; 126520; -.
DR   Ensembl; ENST00000334770.9; ENSP00000466248.1; ENSG00000185988.15. [Q496M5-1]
DR   Ensembl; ENST00000454744.7; ENSP00000468376.1; ENSG00000185988.15. [Q496M5-1]
DR   Ensembl; ENST00000588430.3; ENSP00000465896.2; ENSG00000185988.15. [Q496M5-2]
DR   Ensembl; ENST00000673796.1; ENSP00000501198.1; ENSG00000185988.15. [Q496M5-1]
DR   Ensembl; ENST00000673896.1; ENSP00000501063.1; ENSG00000185988.15. [Q496M5-2]
DR   GeneID; 126520; -.
DR   KEGG; hsa:126520; -.
DR   MANE-Select; ENST00000454744.7; ENSP00000468376.1; NM_001243079.2; NP_001230008.1.
DR   UCSC; uc002ltf.4; human. [Q496M5-1]
DR   AGR; HGNC:27001; -.
DR   CTD; 126520; -.
DR   DisGeNET; 126520; -.
DR   GeneCards; PLK5; -.
DR   HGNC; HGNC:27001; PLK5.
DR   HPA; ENSG00000185988; Tissue enhanced (brain, cervix).
DR   neXtProt; NX_Q496M5; -.
DR   OpenTargets; ENSG00000185988; -.
DR   VEuPathDB; HostDB:ENSG00000185988; -.
DR   eggNOG; KOG0575; Eukaryota.
DR   GeneTree; ENSGT00940000162321; -.
DR   HOGENOM; CLU_830408_0_0_1; -.
DR   InParanoid; Q496M5; -.
DR   OMA; HLQHAIH; -.
DR   OrthoDB; 5471704at2759; -.
DR   PhylomeDB; Q496M5; -.
DR   PathwayCommons; Q496M5; -.
DR   BioGRID-ORCS; 126520; 10 hits in 1135 CRISPR screens.
DR   ChiTaRS; PLK5; human.
DR   GenomeRNAi; 126520; -.
DR   Pharos; Q496M5; Tbio.
DR   PRO; PR:Q496M5; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q496M5; Protein.
DR   Bgee; ENSG00000185988; Expressed in right hemisphere of cerebellum and 92 other cell types or tissues.
DR   ExpressionAtlas; Q496M5; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071363; P:cellular response to growth factor stimulus; IDA:UniProtKB.
DR   GO; GO:0002357; P:defense response to tumor cell; IDA:UniProtKB.
DR   GO; GO:0010976; P:positive regulation of neuron projection development; IDA:UniProtKB.
DR   GO; GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB.
DR   GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IMP:UniProtKB.
DR   CDD; cd13118; POLO_box_1; 1.
DR   Gene3D; 3.30.1120.30; POLO box domain; 2.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR033701; POLO_box_1.
DR   InterPro; IPR036947; POLO_box_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   PANTHER; PTHR24345:SF43; INACTIVE SERINE_THREONINE-PROTEIN KINASE PLK5; 1.
DR   PANTHER; PTHR24345; SERINE/THREONINE-PROTEIN KINASE PLK; 1.
DR   SUPFAM; SSF82615; Polo-box domain; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50078; POLO_BOX; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   Genevisible; Q496M5; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell cycle; Cell division; Cytoplasm;
KW   Differentiation; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..336
FT                   /note="Inactive serine/threonine-protein kinase PLK5"
FT                   /id="PRO_0000280397"
FT   DOMAIN          1..65
FT                   /note="Protein kinase; truncated"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   DOMAIN          255..336
FT                   /note="POLO box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00154"
FT   REGION          109..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          224..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         239..275
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_023654"
FT   CONFLICT        314
FT                   /note="R -> Q (in Ref. 1; BAG51426 and 4; BC100791)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        320
FT                   /note="Missing (in Ref. 2; ABD83663)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        323
FT                   /note="G -> R (in Ref. 2; ABD83663)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   336 AA;  36329 MW;  782A33DF18A7E445 CRC64;
     MYTVLTGTPP FMASPLSEMY QNIREGHYPE PAHLSANARR LIVHLLAPNP AERPSLDHLL
     QDDFFTQGFT PDRLPAHSCH SPPIFAIPPP LGRIFRKVGQ RLLTQCRPPC PFTPKEASGP
     GEGGPDPDSM EWDGESSLSA KEVPCLEGPI HLVAQGTLQS DLAGPEGSRR PEVEAALRHL
     QLCLDVGPPA TQDPLGEQQP ILWAPKWVDY SSKYGFGYQL LDGGRTGRHP HGPATPRREG
     TLPTPVPPAG PGLCLLRFLA SEHALLLLFS NGMVQVSFSG VPAQLVLSGE GEGLQLTLWE
     QGSPGTSYSL DVPRSHGCAP TTGQHLHHAL RMLQSI
//