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Q496M5

- PLK5_HUMAN

UniProt

Q496M5 - PLK5_HUMAN

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Protein

Inactive serine/threonine-protein kinase PLK5

Gene
PLK5, PLK5P, FG060302
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation.1 Publication

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein kinase activity Source: InterPro

GO - Biological processi

  1. cellular response to growth factor stimulus Source: UniProtKB
  2. defense response to tumor cell Source: UniProtKB
  3. G2 DNA damage checkpoint Source: UniProtKB
  4. mitotic nuclear division Source: UniProtKB-KW
  5. positive regulation of neuron projection development Source: UniProtKB
  6. regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
  7. transformed cell apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Differentiation, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive serine/threonine-protein kinase PLK5
Alternative name(s):
Polo-like kinase 5
Short name:
PLK-5
Gene namesi
Name:PLK5
Synonyms:PLK5P
ORF Names:FG060302
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:27001. PLK5.

Subcellular locationi

Nucleusnucleolus By similarity. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Inactive serine/threonine-protein kinase PLK5PRO_0000280397Add
BLAST

Proteomic databases

PaxDbiQ496M5.
PRIDEiQ496M5.

PTM databases

PhosphoSiteiQ496M5.

Expressioni

Tissue specificityi

Expressed in the brain, neurons and glial cells. Also expressed in highly differentiated cells, such as the serous acini in the parotid gland, distal and proximal tubules of the kidney, tubules of the seminal gland, Kupffer cells and some hepatocytes in the liver, and some cells in the germinal center of lymph nodes (at protein level).1 Publication

Inductioni

Down-regulated in primary brain tumors.1 Publication

Gene expression databases

ArrayExpressiQ496M5.
BgeeiQ496M5.
GenevestigatoriQ496M5.

Organism-specific databases

HPAiHPA035024.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334428.

Structurei

3D structure databases

ProteinModelPortaliQ496M5.
SMRiQ496M5. Positions 1-85.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6565Protein kinase; truncatedAdd
BLAST
Domaini259 – 33476POLO boxAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi265 – 2684Poly-Leu

Domaini

The truncated protein kinase domain is predicted to be catalytically inactive; has lost the main activatory autophosphorylation site and the conserved key residues involved in phospho-substrate. The C-terminal region (containing the POLO box domain) is sufficient for inducing cell cycle arrest.

Sequence similaritiesi

Contains 1 POLO box domain.

Phylogenomic databases

eggNOGiNOG290091.
HOVERGENiHBG001843.
InParanoidiQ496M5.
OMAiCLDAGPP.
OrthoDBiEOG78M01K.
PhylomeDBiQ496M5.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q496M5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MYTVLTGTPP FMASPLSEMY QNIREGHYPE PAHLSANARR LIVHLLAPNP    50
AERPSLDHLL QDDFFTQGFT PDRLPAHSCH SPPIFAIPPP LGRIFRKVGQ 100
RLLTQCRPPC PFTPKEASGP GEGGPDPDSM EWDGESSLSA KEVPCLEGPI 150
HLVAQGTLQS DLAGPEGSRR PEVEAALRHL QLCLDVGPPA TQDPLGEQQP 200
ILWAPKWVDY SSKYGFGYQL LDGGRTGRHP HGPATPRREG TLPTPVPPAG 250
PGLCLLRFLA SEHALLLLFS NGMVQVSFSG VPAQLVLSGE GEGLQLTLWE 300
QGSPGTSYSL DVPRSHGCAP TTGQHLHHAL RMLQSI 336
Length:336
Mass (Da):36,329
Last modified:October 5, 2010 - v4
Checksum:i782A33DF18A7E445
GO
Isoform 2 (identifier: Q496M5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-275: Missing.

Note: No experimental confirmation available.

Show »
Length:299
Mass (Da):32,487
Checksum:i96FCA8A80BEDA446
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei239 – 27537Missing in isoform 2. VSP_023654Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti314 – 3141R → Q in BAG51426. 1 Publication
Sequence conflicti314 – 3141R → Q in BC100791. 1 Publication
Sequence conflicti320 – 3201Missing in ABD83663. 1 Publication
Sequence conflicti323 – 3231G → R in ABD83663. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK054808 mRNA. Translation: BAG51426.1.
DQ424898 mRNA. Translation: ABD83663.1.
AC027307 Genomic DNA. No translation available.
BC100791 mRNA. No translation available.
CCDSiCCDS59328.1. [Q496M5-1]
RefSeqiNP_001230008.1. NM_001243079.1. [Q496M5-1]
UniGeneiHs.195352.

Genome annotation databases

EnsembliENST00000334770; ENSP00000466248; ENSG00000185988. [Q496M5-1]
ENST00000454744; ENSP00000468376; ENSG00000185988. [Q496M5-1]
GeneIDi126520.
KEGGihsa:126520.
UCSCiuc002ltf.3. human. [Q496M5-1]
uc010dsm.1. human. [Q496M5-2]

Polymorphism databases

DMDMi308153664.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK054808 mRNA. Translation: BAG51426.1 .
DQ424898 mRNA. Translation: ABD83663.1 .
AC027307 Genomic DNA. No translation available.
BC100791 mRNA. No translation available.
CCDSi CCDS59328.1. [Q496M5-1 ]
RefSeqi NP_001230008.1. NM_001243079.1. [Q496M5-1 ]
UniGenei Hs.195352.

3D structure databases

ProteinModelPortali Q496M5.
SMRi Q496M5. Positions 1-85.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000334428.

PTM databases

PhosphoSitei Q496M5.

Polymorphism databases

DMDMi 308153664.

Proteomic databases

PaxDbi Q496M5.
PRIDEi Q496M5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334770 ; ENSP00000466248 ; ENSG00000185988 . [Q496M5-1 ]
ENST00000454744 ; ENSP00000468376 ; ENSG00000185988 . [Q496M5-1 ]
GeneIDi 126520.
KEGGi hsa:126520.
UCSCi uc002ltf.3. human. [Q496M5-1 ]
uc010dsm.1. human. [Q496M5-2 ]

Organism-specific databases

CTDi 126520.
GeneCardsi GC19P001525.
HGNCi HGNC:27001. PLK5.
HPAi HPA035024.
neXtProti NX_Q496M5.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG290091.
HOVERGENi HBG001843.
InParanoidi Q496M5.
OMAi CLDAGPP.
OrthoDBi EOG78M01K.
PhylomeDBi Q496M5.

Miscellaneous databases

GenomeRNAii 126520.
NextBioi 81836.
PROi Q496M5.

Gene expression databases

ArrayExpressi Q496M5.
Bgeei Q496M5.
Genevestigatori Q496M5.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cerebellum.
  2. Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Liang M., Tang Z., Huang B., Lin L., Yang S.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression."
    de Carcer G., Escobar B., Higuero A.M., Garcia L., Anson A., Perez G., Mollejo M., Manning G., Melendez B., Abad-Rodriguez J., Malumbres M.
    Mol. Cell. Biol. 31:1225-1239(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPLK5_HUMAN
AccessioniPrimary (citable) accession number: Q496M5
Secondary accession number(s): B3KNR4, Q1ZYM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 79 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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