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Q496M5

- PLK5_HUMAN

UniProt

Q496M5 - PLK5_HUMAN

Protein

Inactive serine/threonine-protein kinase PLK5

Gene

PLK5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 4 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation.1 Publication

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. protein kinase activity Source: InterPro

    GO - Biological processi

    1. cellular response to growth factor stimulus Source: UniProtKB
    2. defense response to tumor cell Source: UniProtKB
    3. G2 DNA damage checkpoint Source: UniProtKB
    4. mitotic nuclear division Source: UniProtKB-KW
    5. positive regulation of neuron projection development Source: UniProtKB
    6. regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
    7. transformed cell apoptotic process Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Differentiation, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive serine/threonine-protein kinase PLK5
    Alternative name(s):
    Polo-like kinase 5
    Short name:
    PLK-5
    Gene namesi
    Name:PLK5
    Synonyms:PLK5P
    ORF Names:FG060302
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:27001. PLK5.

    Subcellular locationi

    Nucleusnucleolus By similarity. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 336336Inactive serine/threonine-protein kinase PLK5PRO_0000280397Add
    BLAST

    Proteomic databases

    PaxDbiQ496M5.
    PRIDEiQ496M5.

    PTM databases

    PhosphoSiteiQ496M5.

    Expressioni

    Tissue specificityi

    Expressed in the brain, neurons and glial cells. Also expressed in highly differentiated cells, such as the serous acini in the parotid gland, distal and proximal tubules of the kidney, tubules of the seminal gland, Kupffer cells and some hepatocytes in the liver, and some cells in the germinal center of lymph nodes (at protein level).1 Publication

    Inductioni

    Down-regulated in primary brain tumors.1 Publication

    Gene expression databases

    ArrayExpressiQ496M5.
    BgeeiQ496M5.
    GenevestigatoriQ496M5.

    Organism-specific databases

    HPAiHPA035024.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000334428.

    Structurei

    3D structure databases

    ProteinModelPortaliQ496M5.
    SMRiQ496M5. Positions 1-85.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 6565Protein kinase; truncatedPROSITE-ProRule annotationAdd
    BLAST
    Domaini259 – 33476POLO boxAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi265 – 2684Poly-Leu

    Domaini

    The truncated protein kinase domain is predicted to be catalytically inactive; has lost the main activatory autophosphorylation site and the conserved key residues involved in phospho-substrate. The C-terminal region (containing the POLO box domain) is sufficient for inducing cell cycle arrest.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.PROSITE-ProRule annotation
    Contains 1 POLO box domain.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG290091.
    HOVERGENiHBG001843.
    InParanoidiQ496M5.
    OMAiCLDAGPP.
    OrthoDBiEOG78M01K.
    PhylomeDBiQ496M5.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q496M5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYTVLTGTPP FMASPLSEMY QNIREGHYPE PAHLSANARR LIVHLLAPNP    50
    AERPSLDHLL QDDFFTQGFT PDRLPAHSCH SPPIFAIPPP LGRIFRKVGQ 100
    RLLTQCRPPC PFTPKEASGP GEGGPDPDSM EWDGESSLSA KEVPCLEGPI 150
    HLVAQGTLQS DLAGPEGSRR PEVEAALRHL QLCLDVGPPA TQDPLGEQQP 200
    ILWAPKWVDY SSKYGFGYQL LDGGRTGRHP HGPATPRREG TLPTPVPPAG 250
    PGLCLLRFLA SEHALLLLFS NGMVQVSFSG VPAQLVLSGE GEGLQLTLWE 300
    QGSPGTSYSL DVPRSHGCAP TTGQHLHHAL RMLQSI 336
    Length:336
    Mass (Da):36,329
    Last modified:October 5, 2010 - v4
    Checksum:i782A33DF18A7E445
    GO
    Isoform 2 (identifier: Q496M5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         239-275: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:299
    Mass (Da):32,487
    Checksum:i96FCA8A80BEDA446
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti314 – 3141R → Q in BAG51426. (PubMed:14702039)Curated
    Sequence conflicti314 – 3141R → Q in BC100791. (PubMed:15489334)Curated
    Sequence conflicti320 – 3201Missing in ABD83663. 1 PublicationCurated
    Sequence conflicti323 – 3231G → R in ABD83663. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei239 – 27537Missing in isoform 2. 1 PublicationVSP_023654Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK054808 mRNA. Translation: BAG51426.1.
    DQ424898 mRNA. Translation: ABD83663.1.
    AC027307 Genomic DNA. No translation available.
    BC100791 mRNA. No translation available.
    CCDSiCCDS59328.1. [Q496M5-1]
    RefSeqiNP_001230008.1. NM_001243079.1. [Q496M5-1]
    UniGeneiHs.195352.

    Genome annotation databases

    EnsembliENST00000334770; ENSP00000466248; ENSG00000185988. [Q496M5-1]
    ENST00000454744; ENSP00000468376; ENSG00000185988. [Q496M5-1]
    GeneIDi126520.
    KEGGihsa:126520.
    UCSCiuc002ltf.3. human. [Q496M5-1]
    uc010dsm.1. human. [Q496M5-2]

    Polymorphism databases

    DMDMi308153664.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK054808 mRNA. Translation: BAG51426.1 .
    DQ424898 mRNA. Translation: ABD83663.1 .
    AC027307 Genomic DNA. No translation available.
    BC100791 mRNA. No translation available.
    CCDSi CCDS59328.1. [Q496M5-1 ]
    RefSeqi NP_001230008.1. NM_001243079.1. [Q496M5-1 ]
    UniGenei Hs.195352.

    3D structure databases

    ProteinModelPortali Q496M5.
    SMRi Q496M5. Positions 1-85.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000334428.

    PTM databases

    PhosphoSitei Q496M5.

    Polymorphism databases

    DMDMi 308153664.

    Proteomic databases

    PaxDbi Q496M5.
    PRIDEi Q496M5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334770 ; ENSP00000466248 ; ENSG00000185988 . [Q496M5-1 ]
    ENST00000454744 ; ENSP00000468376 ; ENSG00000185988 . [Q496M5-1 ]
    GeneIDi 126520.
    KEGGi hsa:126520.
    UCSCi uc002ltf.3. human. [Q496M5-1 ]
    uc010dsm.1. human. [Q496M5-2 ]

    Organism-specific databases

    CTDi 126520.
    GeneCardsi GC19P001525.
    HGNCi HGNC:27001. PLK5.
    HPAi HPA035024.
    neXtProti NX_Q496M5.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290091.
    HOVERGENi HBG001843.
    InParanoidi Q496M5.
    OMAi CLDAGPP.
    OrthoDBi EOG78M01K.
    PhylomeDBi Q496M5.

    Miscellaneous databases

    GenomeRNAii 126520.
    NextBioi 81836.
    PROi Q496M5.

    Gene expression databases

    ArrayExpressi Q496M5.
    Bgeei Q496M5.
    Genevestigatori Q496M5.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cerebellum.
    2. Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Liang M., Tang Z., Huang B., Lin L., Yang S.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression."
      de Carcer G., Escobar B., Higuero A.M., Garcia L., Anson A., Perez G., Mollejo M., Manning G., Melendez B., Abad-Rodriguez J., Malumbres M.
      Mol. Cell. Biol. 31:1225-1239(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPLK5_HUMAN
    AccessioniPrimary (citable) accession number: Q496M5
    Secondary accession number(s): B3KNR4, Q1ZYM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 80 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3