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Protein

Inactive serine/threonine-protein kinase PLK5

Gene

PLK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cellular response to growth factor stimulus Source: UniProtKB
  • defense response to tumor cell Source: UniProtKB
  • G2 DNA damage checkpoint Source: UniProtKB
  • mitotic nuclear division Source: UniProtKB-KW
  • positive regulation of neuron projection development Source: UniProtKB
  • regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Differentiation, Mitosis

Enzyme and pathway databases

BioCyciZFISH:G66-32136-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive serine/threonine-protein kinase PLK5
Alternative name(s):
Polo-like kinase 5
Short name:
PLK-5
Gene namesi
Name:PLK5
Synonyms:PLK5P
ORF Names:FG060302
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:27001. PLK5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi126520.
OpenTargetsiENSG00000185988.

Polymorphism and mutation databases

BioMutaiPLK5.
DMDMi308153664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002803971 – 336Inactive serine/threonine-protein kinase PLK5Add BLAST336

Proteomic databases

PaxDbiQ496M5.
PRIDEiQ496M5.

PTM databases

PhosphoSitePlusiQ496M5.

Expressioni

Tissue specificityi

Expressed in the brain, neurons and glial cells. Also expressed in highly differentiated cells, such as the serous acini in the parotid gland, distal and proximal tubules of the kidney, tubules of the seminal gland, Kupffer cells and some hepatocytes in the liver, and some cells in the germinal center of lymph nodes (at protein level).1 Publication

Inductioni

Down-regulated in primary brain tumors.1 Publication

Gene expression databases

BgeeiENSG00000185988.
GenevisibleiQ496M5. HS.

Organism-specific databases

HPAiHPA035024.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000466248.

Structurei

3D structure databases

ProteinModelPortaliQ496M5.
SMRiQ496M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 65Protein kinase; truncatedPROSITE-ProRule annotationAdd BLAST65
Domaini259 – 334POLO boxAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi265 – 268Poly-Leu4

Domaini

The truncated protein kinase domain is predicted to be catalytically inactive; has lost the main activatory autophosphorylation site and the conserved key residues involved in phospho-substrate. The C-terminal region (containing the POLO box domain) is sufficient for inducing cell cycle arrest.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.PROSITE-ProRule annotation
Contains 1 POLO box domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0575. Eukaryota.
ENOG410XQBP. LUCA.
GeneTreeiENSGT00530000062954.
HOVERGENiHBG001843.
InParanoidiQ496M5.
KOiK19596.
OMAiSEREAPC.
OrthoDBiEOG091G0D89.
PhylomeDBiQ496M5.

Family and domain databases

CDDicd13118. POLO_box_1. 1 hit.
Gene3Di3.30.1120.30. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR033701. POLO_box_1.
IPR000959. POLO_box_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q496M5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYTVLTGTPP FMASPLSEMY QNIREGHYPE PAHLSANARR LIVHLLAPNP
60 70 80 90 100
AERPSLDHLL QDDFFTQGFT PDRLPAHSCH SPPIFAIPPP LGRIFRKVGQ
110 120 130 140 150
RLLTQCRPPC PFTPKEASGP GEGGPDPDSM EWDGESSLSA KEVPCLEGPI
160 170 180 190 200
HLVAQGTLQS DLAGPEGSRR PEVEAALRHL QLCLDVGPPA TQDPLGEQQP
210 220 230 240 250
ILWAPKWVDY SSKYGFGYQL LDGGRTGRHP HGPATPRREG TLPTPVPPAG
260 270 280 290 300
PGLCLLRFLA SEHALLLLFS NGMVQVSFSG VPAQLVLSGE GEGLQLTLWE
310 320 330
QGSPGTSYSL DVPRSHGCAP TTGQHLHHAL RMLQSI
Length:336
Mass (Da):36,329
Last modified:October 5, 2010 - v4
Checksum:i782A33DF18A7E445
GO
Isoform 2 (identifier: Q496M5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-275: Missing.

Note: No experimental confirmation available.
Show »
Length:299
Mass (Da):32,487
Checksum:i96FCA8A80BEDA446
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti314R → Q in BAG51426 (PubMed:14702039).Curated1
Sequence conflicti314R → Q in BC100791 (PubMed:15489334).Curated1
Sequence conflicti320Missing in ABD83663 (Ref. 2) Curated1
Sequence conflicti323G → R in ABD83663 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023654239 – 275Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054808 mRNA. Translation: BAG51426.1.
DQ424898 mRNA. Translation: ABD83663.1.
AC027307 Genomic DNA. No translation available.
BC100791 mRNA. No translation available.
CCDSiCCDS59328.1. [Q496M5-1]
RefSeqiNP_001230008.1. NM_001243079.1. [Q496M5-1]
UniGeneiHs.195352.

Genome annotation databases

EnsembliENST00000334770; ENSP00000466248; ENSG00000185988. [Q496M5-1]
ENST00000454744; ENSP00000468376; ENSG00000185988. [Q496M5-1]
ENST00000588430; ENSP00000465896; ENSG00000185988. [Q496M5-2]
GeneIDi126520.
KEGGihsa:126520.
UCSCiuc002ltf.4. human. [Q496M5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054808 mRNA. Translation: BAG51426.1.
DQ424898 mRNA. Translation: ABD83663.1.
AC027307 Genomic DNA. No translation available.
BC100791 mRNA. No translation available.
CCDSiCCDS59328.1. [Q496M5-1]
RefSeqiNP_001230008.1. NM_001243079.1. [Q496M5-1]
UniGeneiHs.195352.

3D structure databases

ProteinModelPortaliQ496M5.
SMRiQ496M5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000466248.

PTM databases

PhosphoSitePlusiQ496M5.

Polymorphism and mutation databases

BioMutaiPLK5.
DMDMi308153664.

Proteomic databases

PaxDbiQ496M5.
PRIDEiQ496M5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334770; ENSP00000466248; ENSG00000185988. [Q496M5-1]
ENST00000454744; ENSP00000468376; ENSG00000185988. [Q496M5-1]
ENST00000588430; ENSP00000465896; ENSG00000185988. [Q496M5-2]
GeneIDi126520.
KEGGihsa:126520.
UCSCiuc002ltf.4. human. [Q496M5-1]

Organism-specific databases

CTDi126520.
DisGeNETi126520.
GeneCardsiPLK5.
HGNCiHGNC:27001. PLK5.
HPAiHPA035024.
neXtProtiNX_Q496M5.
OpenTargetsiENSG00000185988.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0575. Eukaryota.
ENOG410XQBP. LUCA.
GeneTreeiENSGT00530000062954.
HOVERGENiHBG001843.
InParanoidiQ496M5.
KOiK19596.
OMAiSEREAPC.
OrthoDBiEOG091G0D89.
PhylomeDBiQ496M5.

Enzyme and pathway databases

BioCyciZFISH:G66-32136-MONOMER.

Miscellaneous databases

GenomeRNAii126520.
PROiQ496M5.

Gene expression databases

BgeeiENSG00000185988.
GenevisibleiQ496M5. HS.

Family and domain databases

CDDicd13118. POLO_box_1. 1 hit.
Gene3Di3.30.1120.30. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR033701. POLO_box_1.
IPR000959. POLO_box_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLK5_HUMAN
AccessioniPrimary (citable) accession number: Q496M5
Secondary accession number(s): B3KNR4, Q1ZYM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 99 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.