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Protein

Synaptic vesicle glycoprotein 2C

Gene

SV2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-5250955. Toxicity of botulinum toxin type D (BoNT/D).
R-HSA-5250968. Toxicity of botulinum toxin type A (BoNT/A).
R-HSA-5250981. Toxicity of botulinum toxin type F (BoNT/F).

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2C
Gene namesi
Name:SV2C
Synonyms:KIAA1054
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30670. SV2C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 154154CytoplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Topological domaini176 – 19116ExtracellularSequence analysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Topological domaini213 – 22614CytoplasmicSequence analysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence analysisAdd
BLAST
Topological domaini248 – 2481ExtracellularSequence analysis
Transmembranei249 – 26921HelicalSequence analysisAdd
BLAST
Topological domaini270 – 28011CytoplasmicSequence analysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence analysisAdd
BLAST
Topological domaini302 – 32019ExtracellularSequence analysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence analysisAdd
BLAST
Topological domaini342 – 43796CytoplasmicSequence analysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence analysisAdd
BLAST
Topological domaini459 – 578120ExtracellularSequence analysisAdd
BLAST
Transmembranei579 – 59921HelicalSequence analysisAdd
BLAST
Topological domaini600 – 60910CytoplasmicSequence analysis
Transmembranei610 – 63021HelicalSequence analysisAdd
BLAST
Topological domaini631 – 6366ExtracellularSequence analysis
Transmembranei637 – 65721HelicalSequence analysisAdd
BLAST
Topological domaini658 – 66912CytoplasmicSequence analysisAdd
BLAST
Transmembranei670 – 69021HelicalSequence analysisAdd
BLAST
Topological domaini691 – 6988ExtracellularSequence analysis
Transmembranei699 – 71921HelicalSequence analysisAdd
BLAST
Topological domaini720 – 7278CytoplasmicSequence analysis

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: Reactome
  • synaptic vesicle Source: ParkinsonsUK-UCL
  • synaptic vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25005.

Polymorphism and mutation databases

BioMutaiSV2C.
DMDMi108860965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Synaptic vesicle glycoprotein 2CPRO_0000239771Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence analysis
Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence analysis
Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence analysis
Glycosylationi559 – 5591N-linked (GlcNAc...)Sequence analysis
Glycosylationi565 – 5651N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ496J9.
PeptideAtlasiQ496J9.
PRIDEiQ496J9.

PTM databases

iPTMnetiQ496J9.
PhosphoSiteiQ496J9.

Expressioni

Gene expression databases

BgeeiQ496J9.
CleanExiHS_SV2C.
ExpressionAtlasiQ496J9. baseline and differential.
GenevisibleiQ496J9. HS.

Organism-specific databases

HPAiHPA040722.
HPA040770.

Interactioni

Subunit structurei

Interacts with SYT1 in a calcium-dependent manner.By similarity

Protein-protein interaction databases

BioGridi116636. 7 interactions.
DIPiDIP-60687N.
STRINGi9606.ENSP00000423541.

Structurei

Secondary structure

1
727
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi475 – 4784Combined sources
Beta strandi487 – 4893Combined sources
Beta strandi496 – 4994Combined sources
Beta strandi506 – 5094Combined sources
Beta strandi511 – 5144Combined sources
Beta strandi516 – 5194Combined sources
Beta strandi521 – 5244Combined sources
Beta strandi526 – 5294Combined sources
Beta strandi532 – 5343Combined sources
Beta strandi536 – 5394Combined sources
Beta strandi541 – 5444Combined sources
Helixi549 – 5513Combined sources
Beta strandi557 – 5626Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JRAX-ray2.30C/D456-574[»]
ProteinModelPortaliQ496J9.
SMRiQ496J9. Positions 182-365, 473-565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5757Interaction with SYT1By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
ENOG410YQME. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ496J9.
KOiK06258.
OMAiDFEPYKF.
OrthoDBiEOG74TWZ1.
PhylomeDBiQ496J9.
TreeFamiTF324824.

Family and domain databases

InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q496J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSYKDRTS LMKGAKDIAR EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ
60 70 80 90 100
DEEDDDDYYP AGETYNGEAN DDEGSSEATE GHDEDDEIYE GEYQGIPSMN
110 120 130 140 150
QAKDSIVSVG QPKGDEYKDR RELESERRAD EEELAQQYEL IIQECGHGRF
160 170 180 190 200
QWALFFVLGM ALMADGVEVF VVGFVLPSAE TDLCIPNSGS GWLGSIVYLG
210 220 230 240 250
MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG YGFFLFCRLL
260 270 280 290 300
SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI
310 320 330 340 350
IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV
360 370 380 390 400
GKHDEAWMIL KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG
410 420 430 440 450
TWYRRCFVRI RTELYGIWLT FMRCFNYPVR DNTIKLTIVW FTLSFGYYGL
460 470 480 490 500
SVWFPDVIKP LQSDEYALLT RNVERDKYAN FTINFTMENQ IHTGMEYDNG
510 520 530 540 550
RFIGVKFKSV TFKDSVFKSC TFEDVTSVNT YFKNCTFIDT VFDNTDFEPY
560 570 580 590 600
KFIDSEFKNC SFFHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS
610 620 630 640 650
ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA
660 670 680 690 700
WNSLDVVTVE LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKSIP
710 720
ILLASTVLVC GGLVGLCLPD TRTQVLM
Length:727
Mass (Da):82,342
Last modified:September 13, 2005 - v1
Checksum:i0411B47057B3279C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti346 – 3461F → S in AAI00825 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti482 – 4821T → S.
Corresponds to variant rs2270927 [ dbSNP | Ensembl ].
VAR_050303
Natural varianti543 – 5431D → N.
Corresponds to variant rs31244 [ dbSNP | Ensembl ].
VAR_050304

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100824 mRNA. Translation: AAI00825.1.
BC100825 mRNA. Translation: AAI00826.1.
BC100826 mRNA. Translation: AAI00827.1.
BC100827 mRNA. Translation: AAI00828.1.
AB028977 mRNA. Translation: BAA83006.1.
CCDSiCCDS43331.1.
RefSeqiNP_055794.3. NM_014979.3.
XP_011541583.1. XM_011543281.1.
UniGeneiHs.646953.
Hs.663229.

Genome annotation databases

EnsembliENST00000502798; ENSP00000423541; ENSG00000122012.
GeneIDi22987.
KEGGihsa:22987.
UCSCiuc003kei.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100824 mRNA. Translation: AAI00825.1.
BC100825 mRNA. Translation: AAI00826.1.
BC100826 mRNA. Translation: AAI00827.1.
BC100827 mRNA. Translation: AAI00828.1.
AB028977 mRNA. Translation: BAA83006.1.
CCDSiCCDS43331.1.
RefSeqiNP_055794.3. NM_014979.3.
XP_011541583.1. XM_011543281.1.
UniGeneiHs.646953.
Hs.663229.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JRAX-ray2.30C/D456-574[»]
ProteinModelPortaliQ496J9.
SMRiQ496J9. Positions 182-365, 473-565.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116636. 7 interactions.
DIPiDIP-60687N.
STRINGi9606.ENSP00000423541.

PTM databases

iPTMnetiQ496J9.
PhosphoSiteiQ496J9.

Polymorphism and mutation databases

BioMutaiSV2C.
DMDMi108860965.

Proteomic databases

PaxDbiQ496J9.
PeptideAtlasiQ496J9.
PRIDEiQ496J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502798; ENSP00000423541; ENSG00000122012.
GeneIDi22987.
KEGGihsa:22987.
UCSCiuc003kei.2. human.

Organism-specific databases

CTDi22987.
GeneCardsiSV2C.
HGNCiHGNC:30670. SV2C.
HPAiHPA040722.
HPA040770.
MIMi610291. gene.
neXtProtiNX_Q496J9.
PharmGKBiPA25005.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
ENOG410YQME. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ496J9.
KOiK06258.
OMAiDFEPYKF.
OrthoDBiEOG74TWZ1.
PhylomeDBiQ496J9.
TreeFamiTF324824.

Enzyme and pathway databases

ReactomeiR-HSA-5250955. Toxicity of botulinum toxin type D (BoNT/D).
R-HSA-5250968. Toxicity of botulinum toxin type A (BoNT/A).
R-HSA-5250981. Toxicity of botulinum toxin type F (BoNT/F).

Miscellaneous databases

ChiTaRSiSV2C. human.
GenomeRNAii22987.
PROiQ496J9.
SOURCEiSearch...

Gene expression databases

BgeeiQ496J9.
CleanExiHS_SV2C.
ExpressionAtlasiQ496J9. baseline and differential.
GenevisibleiQ496J9. HS.

Family and domain databases

InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 248-727.
    Tissue: Brain.

Entry informationi

Entry nameiSV2C_HUMAN
AccessioniPrimary (citable) accession number: Q496J9
Secondary accession number(s): Q496K1, Q9UPU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: September 13, 2005
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.