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Protein

Synaptic vesicle glycoprotein 2C

Gene

SV2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.By similarity
(Microbial infection) Receptor for the botulinium neurotoxin type A/BOTA.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-5250955 Toxicity of botulinum toxin type D (BoNT/D)
R-HSA-5250968 Toxicity of botulinum toxin type A (BoNT/A)
R-HSA-5250981 Toxicity of botulinum toxin type F (BoNT/F)

Protein family/group databases

TCDBi2.A.1.22.6 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2C
Gene namesi
Name:SV2C
Synonyms:KIAA1054
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000122012.13
HGNCiHGNC:30670 SV2C
MIMi610291 gene
neXtProtiNX_Q496J9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 154CytoplasmicSequence analysisAdd BLAST154
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 191ExtracellularSequence analysisAdd BLAST16
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 226CytoplasmicSequence analysisAdd BLAST14
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248ExtracellularSequence analysis1
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 280CytoplasmicSequence analysisAdd BLAST11
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 320ExtracellularSequence analysisAdd BLAST19
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 437CytoplasmicSequence analysisAdd BLAST96
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 578ExtracellularSequence analysisAdd BLAST120
Transmembranei579 – 599HelicalSequence analysisAdd BLAST21
Topological domaini600 – 609CytoplasmicSequence analysis10
Transmembranei610 – 630HelicalSequence analysisAdd BLAST21
Topological domaini631 – 636ExtracellularSequence analysis6
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21
Topological domaini658 – 669CytoplasmicSequence analysisAdd BLAST12
Transmembranei670 – 690HelicalSequence analysisAdd BLAST21
Topological domaini691 – 698ExtracellularSequence analysis8
Transmembranei699 – 719HelicalSequence analysisAdd BLAST21
Topological domaini720 – 727CytoplasmicSequence analysis8

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi22987
OpenTargetsiENSG00000122012
PharmGKBiPA25005

Polymorphism and mutation databases

BioMutaiSV2C
DMDMi108860965

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397711 – 727Synaptic vesicle glycoprotein 2CAdd BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphoserineBy similarity1
Modified residuei76PhosphoserineBy similarity1
Modified residuei79PhosphothreonineBy similarity1
Modified residuei466PhosphotyrosineBy similarity1
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi534N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi559N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi565N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ496J9
PeptideAtlasiQ496J9
PRIDEiQ496J9
ProteomicsDBi61995

PTM databases

iPTMnetiQ496J9
PhosphoSitePlusiQ496J9

Expressioni

Gene expression databases

BgeeiENSG00000122012
CleanExiHS_SV2C
ExpressionAtlasiQ496J9 baseline and differential
GenevisibleiQ496J9 HS

Organism-specific databases

HPAiHPA040722
HPA040770

Interactioni

Subunit structurei

Interacts with SYT1 in a calcium-dependent manner.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
botAP108454EBI-16081469,EBI-8178893From Clostridium botulinum.

Protein-protein interaction databases

BioGridi116636, 9 interactors
DIPiDIP-60687N
IntActiQ496J9, 1 interactor
STRINGi9606.ENSP00000423541

Structurei

Secondary structure

1727
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi477 – 483Combined sources7
Beta strandi487 – 494Combined sources8
Beta strandi496 – 504Combined sources9
Beta strandi506 – 514Combined sources9
Beta strandi516 – 519Combined sources4
Beta strandi521 – 524Combined sources4
Beta strandi526 – 529Combined sources4
Beta strandi531 – 534Combined sources4
Beta strandi536 – 539Combined sources4
Beta strandi541 – 544Combined sources4
Helixi549 – 551Combined sources3
Beta strandi552 – 554Combined sources3
Beta strandi556 – 563Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JRAX-ray2.30C/D456-574[»]
5JLVX-ray2.00C/D473-567[»]
5MOYX-ray2.30B456-574[»]
6ES1X-ray2.00B474-567[»]
ProteinModelPortaliQ496J9
SMRiQ496J9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 57Interaction with SYT1By similarityAdd BLAST57
Regioni519 – 566BOTA-binding1 PublicationAdd BLAST48

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
ENOG410YQME LUCA
GeneTreeiENSGT00550000074384
HOGENOMiHOG000065727
HOVERGENiHBG053967
InParanoidiQ496J9
KOiK06258
OMAiFMRCFNY
OrthoDBiEOG091G02NC
PhylomeDBiQ496J9
TreeFamiTF324824

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR001646 5peptide_repeat
IPR011701 MFS
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
IPR022308 SV2
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PF13599 Pentapeptide_4, 1 hit
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR01299 synapt_SV2, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q496J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSYKDRTS LMKGAKDIAR EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ
60 70 80 90 100
DEEDDDDYYP AGETYNGEAN DDEGSSEATE GHDEDDEIYE GEYQGIPSMN
110 120 130 140 150
QAKDSIVSVG QPKGDEYKDR RELESERRAD EEELAQQYEL IIQECGHGRF
160 170 180 190 200
QWALFFVLGM ALMADGVEVF VVGFVLPSAE TDLCIPNSGS GWLGSIVYLG
210 220 230 240 250
MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG YGFFLFCRLL
260 270 280 290 300
SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI
310 320 330 340 350
IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV
360 370 380 390 400
GKHDEAWMIL KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG
410 420 430 440 450
TWYRRCFVRI RTELYGIWLT FMRCFNYPVR DNTIKLTIVW FTLSFGYYGL
460 470 480 490 500
SVWFPDVIKP LQSDEYALLT RNVERDKYAN FTINFTMENQ IHTGMEYDNG
510 520 530 540 550
RFIGVKFKSV TFKDSVFKSC TFEDVTSVNT YFKNCTFIDT VFDNTDFEPY
560 570 580 590 600
KFIDSEFKNC SFFHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS
610 620 630 640 650
ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA
660 670 680 690 700
WNSLDVVTVE LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKSIP
710 720
ILLASTVLVC GGLVGLCLPD TRTQVLM
Length:727
Mass (Da):82,342
Last modified:September 13, 2005 - v1
Checksum:i0411B47057B3279C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti346F → S in AAI00825 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050303482T → S. Corresponds to variant dbSNP:rs2270927Ensembl.1
Natural variantiVAR_050304543D → N. Corresponds to variant dbSNP:rs31244Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100824 mRNA Translation: AAI00825.1
BC100825 mRNA Translation: AAI00826.1
BC100826 mRNA Translation: AAI00827.1
BC100827 mRNA Translation: AAI00828.1
AB028977 mRNA Translation: BAA83006.1
CCDSiCCDS43331.1
RefSeqiNP_055794.3, NM_014979.3
XP_011541583.1, XM_011543281.2
XP_011541584.2, XM_011543282.2
UniGeneiHs.646953
Hs.663229

Genome annotation databases

EnsembliENST00000502798; ENSP00000423541; ENSG00000122012
GeneIDi22987
KEGGihsa:22987
UCSCiuc003kei.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSV2C_HUMAN
AccessioniPrimary (citable) accession number: Q496J9
Secondary accession number(s): Q496K1, Q9UPU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: September 13, 2005
Last modified: June 20, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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