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Protein

Synaptic vesicle glycoprotein 2C

Gene

SV2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-5250955. Toxicity of botulinum toxin type D (BoNT/D).
R-HSA-5250968. Toxicity of botulinum toxin type A (BoNT/A).
R-HSA-5250981. Toxicity of botulinum toxin type F (BoNT/F).

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2C
Gene namesi
Name:SV2C
Synonyms:KIAA1054
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30670. SV2C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 154CytoplasmicSequence analysisAdd BLAST154
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 191ExtracellularSequence analysisAdd BLAST16
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 226CytoplasmicSequence analysisAdd BLAST14
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248ExtracellularSequence analysis1
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 280CytoplasmicSequence analysisAdd BLAST11
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 320ExtracellularSequence analysisAdd BLAST19
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 437CytoplasmicSequence analysisAdd BLAST96
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 578ExtracellularSequence analysisAdd BLAST120
Transmembranei579 – 599HelicalSequence analysisAdd BLAST21
Topological domaini600 – 609CytoplasmicSequence analysis10
Transmembranei610 – 630HelicalSequence analysisAdd BLAST21
Topological domaini631 – 636ExtracellularSequence analysis6
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21
Topological domaini658 – 669CytoplasmicSequence analysisAdd BLAST12
Transmembranei670 – 690HelicalSequence analysisAdd BLAST21
Topological domaini691 – 698ExtracellularSequence analysis8
Transmembranei699 – 719HelicalSequence analysisAdd BLAST21
Topological domaini720 – 727CytoplasmicSequence analysis8

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi22987.
OpenTargetsiENSG00000122012.
PharmGKBiPA25005.

Polymorphism and mutation databases

BioMutaiSV2C.
DMDMi108860965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397711 – 727Synaptic vesicle glycoprotein 2CAdd BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi480N-linked (GlcNAc...)Sequence analysis1
Glycosylationi484N-linked (GlcNAc...)Sequence analysis1
Glycosylationi534N-linked (GlcNAc...)Sequence analysis1
Glycosylationi559N-linked (GlcNAc...)Sequence analysis1
Glycosylationi565N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ496J9.
PeptideAtlasiQ496J9.
PRIDEiQ496J9.

PTM databases

iPTMnetiQ496J9.
PhosphoSitePlusiQ496J9.

Expressioni

Gene expression databases

BgeeiENSG00000122012.
CleanExiHS_SV2C.
ExpressionAtlasiQ496J9. baseline and differential.
GenevisibleiQ496J9. HS.

Organism-specific databases

HPAiHPA040722.
HPA040770.

Interactioni

Subunit structurei

Interacts with SYT1 in a calcium-dependent manner.By similarity

Protein-protein interaction databases

BioGridi116636. 7 interactors.
DIPiDIP-60687N.
STRINGi9606.ENSP00000423541.

Structurei

Secondary structure

1727
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi477 – 483Combined sources7
Beta strandi487 – 494Combined sources8
Beta strandi496 – 504Combined sources9
Beta strandi506 – 514Combined sources9
Beta strandi516 – 519Combined sources4
Beta strandi521 – 524Combined sources4
Beta strandi526 – 529Combined sources4
Beta strandi531 – 534Combined sources4
Beta strandi536 – 539Combined sources4
Beta strandi541 – 544Combined sources4
Helixi549 – 551Combined sources3
Beta strandi552 – 554Combined sources3
Beta strandi556 – 563Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JRAX-ray2.30C/D456-574[»]
5JLVX-ray2.00C/D473-567[»]
ProteinModelPortaliQ496J9.
SMRiQ496J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 57Interaction with SYT1By similarityAdd BLAST57

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
ENOG410YQME. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ496J9.
KOiK06258.
OMAiDFEPYKF.
OrthoDBiEOG091G02NC.
PhylomeDBiQ496J9.
TreeFamiTF324824.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q496J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSYKDRTS LMKGAKDIAR EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ
60 70 80 90 100
DEEDDDDYYP AGETYNGEAN DDEGSSEATE GHDEDDEIYE GEYQGIPSMN
110 120 130 140 150
QAKDSIVSVG QPKGDEYKDR RELESERRAD EEELAQQYEL IIQECGHGRF
160 170 180 190 200
QWALFFVLGM ALMADGVEVF VVGFVLPSAE TDLCIPNSGS GWLGSIVYLG
210 220 230 240 250
MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG YGFFLFCRLL
260 270 280 290 300
SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI
310 320 330 340 350
IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV
360 370 380 390 400
GKHDEAWMIL KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG
410 420 430 440 450
TWYRRCFVRI RTELYGIWLT FMRCFNYPVR DNTIKLTIVW FTLSFGYYGL
460 470 480 490 500
SVWFPDVIKP LQSDEYALLT RNVERDKYAN FTINFTMENQ IHTGMEYDNG
510 520 530 540 550
RFIGVKFKSV TFKDSVFKSC TFEDVTSVNT YFKNCTFIDT VFDNTDFEPY
560 570 580 590 600
KFIDSEFKNC SFFHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS
610 620 630 640 650
ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA
660 670 680 690 700
WNSLDVVTVE LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKSIP
710 720
ILLASTVLVC GGLVGLCLPD TRTQVLM
Length:727
Mass (Da):82,342
Last modified:September 13, 2005 - v1
Checksum:i0411B47057B3279C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti346F → S in AAI00825 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050303482T → S.Corresponds to variant rs2270927dbSNPEnsembl.1
Natural variantiVAR_050304543D → N.Corresponds to variant rs31244dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100824 mRNA. Translation: AAI00825.1.
BC100825 mRNA. Translation: AAI00826.1.
BC100826 mRNA. Translation: AAI00827.1.
BC100827 mRNA. Translation: AAI00828.1.
AB028977 mRNA. Translation: BAA83006.1.
CCDSiCCDS43331.1.
RefSeqiNP_055794.3. NM_014979.3.
XP_011541583.1. XM_011543281.2.
XP_011541584.2. XM_011543282.2.
UniGeneiHs.646953.
Hs.663229.

Genome annotation databases

EnsembliENST00000502798; ENSP00000423541; ENSG00000122012.
GeneIDi22987.
KEGGihsa:22987.
UCSCiuc003kei.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100824 mRNA. Translation: AAI00825.1.
BC100825 mRNA. Translation: AAI00826.1.
BC100826 mRNA. Translation: AAI00827.1.
BC100827 mRNA. Translation: AAI00828.1.
AB028977 mRNA. Translation: BAA83006.1.
CCDSiCCDS43331.1.
RefSeqiNP_055794.3. NM_014979.3.
XP_011541583.1. XM_011543281.2.
XP_011541584.2. XM_011543282.2.
UniGeneiHs.646953.
Hs.663229.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JRAX-ray2.30C/D456-574[»]
5JLVX-ray2.00C/D473-567[»]
ProteinModelPortaliQ496J9.
SMRiQ496J9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116636. 7 interactors.
DIPiDIP-60687N.
STRINGi9606.ENSP00000423541.

PTM databases

iPTMnetiQ496J9.
PhosphoSitePlusiQ496J9.

Polymorphism and mutation databases

BioMutaiSV2C.
DMDMi108860965.

Proteomic databases

PaxDbiQ496J9.
PeptideAtlasiQ496J9.
PRIDEiQ496J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502798; ENSP00000423541; ENSG00000122012.
GeneIDi22987.
KEGGihsa:22987.
UCSCiuc003kei.2. human.

Organism-specific databases

CTDi22987.
DisGeNETi22987.
GeneCardsiSV2C.
HGNCiHGNC:30670. SV2C.
HPAiHPA040722.
HPA040770.
MIMi610291. gene.
neXtProtiNX_Q496J9.
OpenTargetsiENSG00000122012.
PharmGKBiPA25005.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
ENOG410YQME. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ496J9.
KOiK06258.
OMAiDFEPYKF.
OrthoDBiEOG091G02NC.
PhylomeDBiQ496J9.
TreeFamiTF324824.

Enzyme and pathway databases

ReactomeiR-HSA-5250955. Toxicity of botulinum toxin type D (BoNT/D).
R-HSA-5250968. Toxicity of botulinum toxin type A (BoNT/A).
R-HSA-5250981. Toxicity of botulinum toxin type F (BoNT/F).

Miscellaneous databases

ChiTaRSiSV2C. human.
GenomeRNAii22987.
PROiQ496J9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122012.
CleanExiHS_SV2C.
ExpressionAtlasiQ496J9. baseline and differential.
GenevisibleiQ496J9. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSV2C_HUMAN
AccessioniPrimary (citable) accession number: Q496J9
Secondary accession number(s): Q496K1, Q9UPU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: September 13, 2005
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.