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Protein

Neuritin-like protein

Gene

NRN1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-163125. Post-translational modification: synthesis of GPI-anchored proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuritin-like protein
Gene namesi
Name:NRN1L
ORF Names:UNQ2446/PRO5725
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29811. NRN1L.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398187.

Polymorphism and mutation databases

BioMutaiNRN1L.
DMDMi172046108.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000031942936 – 139Neuritin-like proteinAdd BLAST104
PropeptideiPRO_0000319430140 – 165Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi139GPI-anchor amidated alanineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ496H8.
PeptideAtlasiQ496H8.
PRIDEiQ496H8.

Expressioni

Gene expression databases

CleanExiHS_NRN1L.
ExpressionAtlasiQ496H8. baseline.

Organism-specific databases

HPAiHPA041761.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ496H8. 1 interactor.
STRINGi9606.ENSP00000342411.

Structurei

3D structure databases

ProteinModelPortaliQ496H8.
SMRiQ496H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neuritin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYQH. Eukaryota.
ENOG410YSV9. LUCA.
GeneTreeiENSGT00530000063853.
HOVERGENiHBG101254.
InParanoidiQ496H8.
OMAiRSWNDFH.
OrthoDBiEOG091G18TY.
PhylomeDBiQ496H8.
TreeFamiTF332589.

Family and domain databases

InterProiView protein in InterPro
IPR026144. Neuritin_fam.
PANTHERiPTHR15902. PTHR15902. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q496H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRCCRRRCC CRQPPHALRP LLLLPLVLLP PLAAAAAGPN RCDTIYQGFA
60 70 80 90 100
ECLIRLGDSM GRGGELETIC RSWNDFHACA SQVLSGCPEE AAAVWESLQQ
110 120 130 140 150
EARQAPRPNN LHTLCGAPVH VRERGTGSET NQETLRATAP ALPMAPAPPL
160
LAAALALAYL LRPLA
Length:165
Mass (Da):17,786
Last modified:February 26, 2008 - v2
Checksum:i455BD71ADEB6F0CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358782 mRNA. Translation: AAQ89142.1.
CH471092 Genomic DNA. Translation: EAW83184.1.
BC100863 mRNA. Translation: AAI00864.1.
BC100864 mRNA. Translation: AAI00865.1.
BC100865 mRNA. Translation: AAI00866.1.
BC100866 mRNA. Translation: AAI00867.1.
CCDSiCCDS10850.1.
RefSeqiNP_001335611.1. NM_001348682.1.
NP_940845.1. NM_198443.1.
UniGeneiHs.435464.

Genome annotation databases

EnsembliENST00000339176; ENSP00000342411; ENSG00000188038.
GeneIDi123904.
KEGGihsa:123904.
UCSCiuc002euu.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNRN1L_HUMAN
AccessioniPrimary (citable) accession number: Q496H8
Secondary accession number(s): Q6UWH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 5, 2017
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families