Q496H8 (NRN1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuritin-like protein

Gene names

Name:	NRN1L
ORF Names:	UNQ2446/PRO5725

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Potential.
Sequence similarities	Belongs to the neuritin family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
PTM	GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nervous system development Inferred from electronic annotation. Source: InterPro
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 35	35	Potential
	Chain	36 – 139	104	Neuritin-like protein		PRO_0000319429
	Propeptide	140 – 165	26	Removed in mature form Potential		PRO_0000319430
Amino acid modifications
	Lipidation	139	1	GPI-anchor amidated alanine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q496H8 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 455BD71ADEB6F0CC	FASTA	165	17,786
	10 20 30 40 50 60 MMRCCRRRCC CRQPPHALRP LLLLPLVLLP PLAAAAAGPN RCDTIYQGFA ECLIRLGDSM 70 80 90 100 110 120 GRGGELETIC RSWNDFHACA SQVLSGCPEE AAAVWESLQQ EARQAPRPNN LHTLCGAPVH 130 140 150 160 VRERGTGSET NQETLRATAP ALPMAPAPPL LAAALALAYL LRPLA

References

[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358782 mRNA. Translation: AAQ89142.1. CH471092 Genomic DNA. Translation: EAW83184.1. BC100863 mRNA. Translation: AAI00864.1. BC100864 mRNA. Translation: AAI00865.1. BC100865 mRNA. Translation: AAI00866.1. BC100866 mRNA. Translation: AAI00867.1.
IPI	IPI00056040.
RefSeq	NP_940845.1. NM_198443.1.
UniGene	Hs.435464.
3D structure databases
ProteinModelPortal	Q496H8.
ModBase	Search...
Polymorphism databases
DMDM	172046108.
Proteomic databases
PRIDE	Q496H8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339176; ENSP00000342411; ENSG00000188038.
GeneID	123904.
KEGG	hsa:123904.
UCSC	uc002euu.3. human.
Organism-specific databases
CTD	123904.
GeneCards	GC16P067918.
HGNC	HGNC:29811. NRN1L.
HPA	HPA041761.
neXtProt	NX_Q496H8.
PharmGKB	PA162398187.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46282.
HOVERGEN	HBG101254.
InParanoid	Q496H8.
OMA	CRSWNDF.
OrthoDB	EOG412M70.
PhylomeDB	Q496H8.
Gene expression databases
CleanEx	HS_NRN1L.
Genevestigator	Q496H8.
Family and domain databases
InterPro	IPR026144. Neuritin_fam. [Graphical view]
PANTHER	PTHR15902. PTHR15902. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	123904.
NextBio	81190.

Entry information

Entry name

NRN1L_HUMAN

Accession

Primary (citable) accession number: Q496H8
Secondary accession number(s): Q6UWH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	April 3, 2013
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.