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Protein

CMRF35-like molecule 2

Gene

CD300E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably acts as an activating receptor.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
CMRF35-like molecule 2
Short name:
CLM-2
Alternative name(s):
CD300 antigen-like family member E
CMRF35-A5
Immune receptor expressed on myeloid cells 2
Short name:
IREM-2
Polymeric immunoglobulin receptor 2
Short name:
PIgR-2
Short name:
PIgR2
Short name:
Poly-Ig receptor 2
CD_antigen: CD300e
Gene namesi
Name:CD300E
Synonyms:CD300LE, CLM2, CMRF35A5, IREM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28874. CD300E.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 173156ExtracellularSequence analysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence analysisAdd
BLAST
Topological domaini195 – 20511CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672152.

Polymorphism and mutation databases

BioMutaiCD300E.
DMDMi296434454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 205188CMRF35-like molecule 2PRO_0000320123Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 104PROSITE-ProRule annotation
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ496F6.
PeptideAtlasiQ496F6.
PRIDEiQ496F6.

PTM databases

iPTMnetiQ496F6.

Expressioni

Tissue specificityi

Present on the surface of mature hematopoietic cells of the monocyte and myeloid lineages (at protein level).1 Publication

Gene expression databases

BgeeiQ496F6.
CleanExiHS_CD300E.
ExpressionAtlasiQ496F6. baseline and differential.

Organism-specific databases

HPAiHPA015570.

Interactioni

Subunit structurei

Interacts with TYROBP.1 Publication

Protein-protein interaction databases

BioGridi131180. 5 interactions.
STRINGi9606.ENSP00000329942.

Structurei

3D structure databases

ProteinModelPortaliQ496F6.
SMRiQ496F6. Positions 23-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 120103Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Belongs to the CD300 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J48Z. Eukaryota.
ENOG4111DTH. LUCA.
GeneTreeiENSGT00470000042273.
HOGENOMiHOG000231065.
HOVERGENiHBG063279.
InParanoidiQ496F6.
KOiK06719.
OMAiKIQTVWI.
PhylomeDBiQ496F6.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q496F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLPALLLL CLSGCLSLKG PGSVTGTAGD SLTVWCQYES MYKGYNKYWC
60 70 80 90 100
RGQYDTSCES IVETKGEEKV ERNGRVSIRD HPEALAFTVT MQNLNEDDAG
110 120 130 140 150
SYWCKIQTVW VLDSWSRDPS DLVRVYVSPA ITTPRRTTHP ATPPIFLVVN
160 170 180 190 200
PGRNLSTGEV LTQNSGFRLS SPHFLLVVLL KLPLLLSMLG AVFWVNRPQW

APPGR
Length:205
Mass (Da):22,918
Last modified:May 18, 2010 - v2
Checksum:i0486BEA4095A25D3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191K → T.1 Publication
Corresponds to variant rs581157 [ dbSNP | Ensembl ].
VAR_039129
Natural varianti27 – 271T → A in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_039130
Natural varianti158 – 1581G → R.2 Publications
Corresponds to variant rs1878061 [ dbSNP | Ensembl ].
VAR_039131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395839 mRNA. Translation: AAP42154.1.
AK298031 mRNA. Translation: BAG60333.1.
AC064805 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89176.1.
BC100888 mRNA. Translation: AAI00889.1.
BC100889 mRNA. Translation: AAI00890.1.
BC100890 mRNA. Translation: AAI00891.1.
CCDSiCCDS11702.1.
RefSeqiNP_852114.2. NM_181449.2.
UniGeneiHs.158954.

Genome annotation databases

EnsembliENST00000392619; ENSP00000376395; ENSG00000186407.
GeneIDi342510.
KEGGihsa:342510.
UCSCiuc002jlb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395839 mRNA. Translation: AAP42154.1.
AK298031 mRNA. Translation: BAG60333.1.
AC064805 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89176.1.
BC100888 mRNA. Translation: AAI00889.1.
BC100889 mRNA. Translation: AAI00890.1.
BC100890 mRNA. Translation: AAI00891.1.
CCDSiCCDS11702.1.
RefSeqiNP_852114.2. NM_181449.2.
UniGeneiHs.158954.

3D structure databases

ProteinModelPortaliQ496F6.
SMRiQ496F6. Positions 23-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131180. 5 interactions.
STRINGi9606.ENSP00000329942.

PTM databases

iPTMnetiQ496F6.

Polymorphism and mutation databases

BioMutaiCD300E.
DMDMi296434454.

Proteomic databases

PaxDbiQ496F6.
PeptideAtlasiQ496F6.
PRIDEiQ496F6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392619; ENSP00000376395; ENSG00000186407.
GeneIDi342510.
KEGGihsa:342510.
UCSCiuc002jlb.3. human.

Organism-specific databases

CTDi342510.
GeneCardsiCD300E.
HGNCiHGNC:28874. CD300E.
HPAiHPA015570.
MIMi609801. gene.
neXtProtiNX_Q496F6.
PharmGKBiPA142672152.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J48Z. Eukaryota.
ENOG4111DTH. LUCA.
GeneTreeiENSGT00470000042273.
HOGENOMiHOG000231065.
HOVERGENiHBG063279.
InParanoidiQ496F6.
KOiK06719.
OMAiKIQTVWI.
PhylomeDBiQ496F6.
TreeFamiTF334441.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2172127. DAP12 interactions.

Miscellaneous databases

GenomeRNAii342510.
PROiQ496F6.
SOURCEiSearch...

Gene expression databases

BgeeiQ496F6.
CleanExiHS_CD300E.
ExpressionAtlasiQ496F6. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a novel immune receptor restricted to the monocytic lineage."
    Aguilar H., Alvarez-Errico D., Garcia-Montero A.C., Orfao A., Sayos J., Lopez-Botet M.
    J. Immunol. 173:6703-6711(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, GLYCOSYLATION, INTERACTION WITH TYROBP, VARIANT THR-19.
    Tissue: Peripheral blood monocyte.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-158.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-158.
  6. "Novel immunoglobulin superfamily gene cluster, mapping to a region of human chromosome 17q25, linked to psoriasis susceptibility."
    Speckman R.A., Wright Daw J.A., Helms C., Duan S., Cao L., Taillon-Miller P., Kwok P.Y., Menter A., Bowcock A.M.
    Hum. Genet. 112:34-41(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-27.

Entry informationi

Entry nameiCLM2_HUMAN
AccessioniPrimary (citable) accession number: Q496F6
Secondary accession number(s): B4DNS1, Q7Z7I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.