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Protein

CMRF35-like molecule 2

Gene

CD300E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably acts as an activating receptor.1 Publication

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions

Names & Taxonomyi

Protein namesi
Recommended name:
CMRF35-like molecule 2
Short name:
CLM-2
Alternative name(s):
CD300 antigen-like family member E
CMRF35-A5
Immune receptor expressed on myeloid cells 2
Short name:
IREM-2
Polymeric immunoglobulin receptor 2
Short name:
PIgR-2
Short name:
PIgR2
Short name:
Poly-Ig receptor 2
CD_antigen: CD300e
Gene namesi
Name:CD300E
Synonyms:CD300LE, CLM2, CMRF35A5, IREM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000186407.6
HGNCiHGNC:28874 CD300E
MIMi609801 gene
neXtProtiNX_Q496F6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 173ExtracellularSequence analysisAdd BLAST156
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 205CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186407
PharmGKBiPA142672152

Polymorphism and mutation databases

BioMutaiCD300E
DMDMi296434454

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000032012318 – 205CMRF35-like molecule 2Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 104PROSITE-ProRule annotation
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ496F6
PeptideAtlasiQ496F6
PRIDEiQ496F6

PTM databases

iPTMnetiQ496F6
PhosphoSitePlusiQ496F6

Expressioni

Tissue specificityi

Present on the surface of mature hematopoietic cells of the monocyte and myeloid lineages (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000186407
CleanExiHS_CD300E
ExpressionAtlasiQ496F6 baseline and differential

Organism-specific databases

HPAiHPA015570

Interactioni

Subunit structurei

Interacts with TYROBP.1 Publication

Protein-protein interaction databases

BioGridi1311808 interactors.
STRINGi9606.ENSP00000329942

Structurei

3D structure databases

ProteinModelPortaliQ496F6
SMRiQ496F6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 120Ig-like V-typeAdd BLAST103

Sequence similaritiesi

Belongs to the CD300 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J48Z Eukaryota
ENOG4111DTH LUCA
GeneTreeiENSGT00470000042273
HOGENOMiHOG000231065
HOVERGENiHBG063279
InParanoidiQ496F6
KOiK06719
OMAiIQTVWIL
OrthoDBiEOG091G0RAD
PhylomeDBiQ496F6
TreeFamiTF334441

Family and domain databases

Gene3Di2.60.40.101 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q496F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLPALLLL CLSGCLSLKG PGSVTGTAGD SLTVWCQYES MYKGYNKYWC
60 70 80 90 100
RGQYDTSCES IVETKGEEKV ERNGRVSIRD HPEALAFTVT MQNLNEDDAG
110 120 130 140 150
SYWCKIQTVW VLDSWSRDPS DLVRVYVSPA ITTPRRTTHP ATPPIFLVVN
160 170 180 190 200
PGRNLSTGEV LTQNSGFRLS SPHFLLVVLL KLPLLLSMLG AVFWVNRPQW

APPGR
Length:205
Mass (Da):22,918
Last modified:May 18, 2010 - v2
Checksum:i0486BEA4095A25D3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03912919K → T1 PublicationCorresponds to variant dbSNP:rs581157Ensembl.1
Natural variantiVAR_03913027T → A in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_039131158G → R2 PublicationsCorresponds to variant dbSNP:rs1878061Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395839 mRNA Translation: AAP42154.1
AK298031 mRNA Translation: BAG60333.1
AC064805 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89176.1
BC100888 mRNA Translation: AAI00889.1
BC100889 mRNA Translation: AAI00890.1
BC100890 mRNA Translation: AAI00891.1
CCDSiCCDS11702.1
RefSeqiNP_852114.2, NM_181449.2
UniGeneiHs.158954

Genome annotation databases

EnsembliENST00000392619; ENSP00000376395; ENSG00000186407
GeneIDi342510
KEGGihsa:342510
UCSCiuc002jlb.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCLM2_HUMAN
AccessioniPrimary (citable) accession number: Q496F6
Secondary accession number(s): B4DNS1, Q7Z7I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: February 28, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome