Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CMRF35-like molecule 2

Gene

CD300E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably acts as an activating receptor.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Enzyme and pathway databases

BioCyciZFISH:G66-31753-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
CMRF35-like molecule 2
Short name:
CLM-2
Alternative name(s):
CD300 antigen-like family member E
CMRF35-A5
Immune receptor expressed on myeloid cells 2
Short name:
IREM-2
Polymeric immunoglobulin receptor 2
Short name:
PIgR-2
Short name:
PIgR2
Short name:
Poly-Ig receptor 2
CD_antigen: CD300e
Gene namesi
Name:CD300E
Synonyms:CD300LE, CLM2, CMRF35A5, IREM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28874. CD300E.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 173ExtracellularSequence analysisAdd BLAST156
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 205CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186407.
PharmGKBiPA142672152.

Polymorphism and mutation databases

BioMutaiCD300E.
DMDMi296434454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000032012318 – 205CMRF35-like molecule 2Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 104PROSITE-ProRule annotation
Glycosylationi154N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ496F6.
PeptideAtlasiQ496F6.
PRIDEiQ496F6.

PTM databases

iPTMnetiQ496F6.
PhosphoSitePlusiQ496F6.

Expressioni

Tissue specificityi

Present on the surface of mature hematopoietic cells of the monocyte and myeloid lineages (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000186407.
CleanExiHS_CD300E.
ExpressionAtlasiQ496F6. baseline and differential.

Organism-specific databases

HPAiHPA015570.

Interactioni

Subunit structurei

Interacts with TYROBP.1 Publication

Protein-protein interaction databases

BioGridi131180. 5 interactors.
STRINGi9606.ENSP00000329942.

Structurei

3D structure databases

ProteinModelPortaliQ496F6.
SMRiQ496F6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 120Ig-like V-typeAdd BLAST103

Sequence similaritiesi

Belongs to the CD300 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J48Z. Eukaryota.
ENOG4111DTH. LUCA.
GeneTreeiENSGT00470000042273.
HOGENOMiHOG000231065.
HOVERGENiHBG063279.
InParanoidiQ496F6.
KOiK06719.
OMAiKIQTVWI.
OrthoDBiEOG091G0RAD.
PhylomeDBiQ496F6.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q496F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLPALLLL CLSGCLSLKG PGSVTGTAGD SLTVWCQYES MYKGYNKYWC
60 70 80 90 100
RGQYDTSCES IVETKGEEKV ERNGRVSIRD HPEALAFTVT MQNLNEDDAG
110 120 130 140 150
SYWCKIQTVW VLDSWSRDPS DLVRVYVSPA ITTPRRTTHP ATPPIFLVVN
160 170 180 190 200
PGRNLSTGEV LTQNSGFRLS SPHFLLVVLL KLPLLLSMLG AVFWVNRPQW

APPGR
Length:205
Mass (Da):22,918
Last modified:May 18, 2010 - v2
Checksum:i0486BEA4095A25D3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03912919K → T.1 PublicationCorresponds to variant rs581157dbSNPEnsembl.1
Natural variantiVAR_03913027T → A in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_039131158G → R.2 PublicationsCorresponds to variant rs1878061dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395839 mRNA. Translation: AAP42154.1.
AK298031 mRNA. Translation: BAG60333.1.
AC064805 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89176.1.
BC100888 mRNA. Translation: AAI00889.1.
BC100889 mRNA. Translation: AAI00890.1.
BC100890 mRNA. Translation: AAI00891.1.
CCDSiCCDS11702.1.
RefSeqiNP_852114.2. NM_181449.2.
UniGeneiHs.158954.

Genome annotation databases

EnsembliENST00000392619; ENSP00000376395; ENSG00000186407.
GeneIDi342510.
KEGGihsa:342510.
UCSCiuc002jlb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395839 mRNA. Translation: AAP42154.1.
AK298031 mRNA. Translation: BAG60333.1.
AC064805 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89176.1.
BC100888 mRNA. Translation: AAI00889.1.
BC100889 mRNA. Translation: AAI00890.1.
BC100890 mRNA. Translation: AAI00891.1.
CCDSiCCDS11702.1.
RefSeqiNP_852114.2. NM_181449.2.
UniGeneiHs.158954.

3D structure databases

ProteinModelPortaliQ496F6.
SMRiQ496F6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131180. 5 interactors.
STRINGi9606.ENSP00000329942.

PTM databases

iPTMnetiQ496F6.
PhosphoSitePlusiQ496F6.

Polymorphism and mutation databases

BioMutaiCD300E.
DMDMi296434454.

Proteomic databases

PaxDbiQ496F6.
PeptideAtlasiQ496F6.
PRIDEiQ496F6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392619; ENSP00000376395; ENSG00000186407.
GeneIDi342510.
KEGGihsa:342510.
UCSCiuc002jlb.3. human.

Organism-specific databases

CTDi342510.
GeneCardsiCD300E.
HGNCiHGNC:28874. CD300E.
HPAiHPA015570.
MIMi609801. gene.
neXtProtiNX_Q496F6.
OpenTargetsiENSG00000186407.
PharmGKBiPA142672152.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J48Z. Eukaryota.
ENOG4111DTH. LUCA.
GeneTreeiENSGT00470000042273.
HOGENOMiHOG000231065.
HOVERGENiHBG063279.
InParanoidiQ496F6.
KOiK06719.
OMAiKIQTVWI.
OrthoDBiEOG091G0RAD.
PhylomeDBiQ496F6.
TreeFamiTF334441.

Enzyme and pathway databases

BioCyciZFISH:G66-31753-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2172127. DAP12 interactions.

Miscellaneous databases

GenomeRNAii342510.
PROiQ496F6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186407.
CleanExiHS_CD300E.
ExpressionAtlasiQ496F6. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLM2_HUMAN
AccessioniPrimary (citable) accession number: Q496F6
Secondary accession number(s): B4DNS1, Q7Z7I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.