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Protein

Spermatogenesis-associated serine-rich protein 1

Gene

SPATS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated serine-rich protein 1
Gene namesi
Name:SPATS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:22957. SPATS1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000249481.
PharmGKBiPA134922278.

Polymorphism and mutation databases

BioMutaiSPATS1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003076941 – 300Spermatogenesis-associated serine-rich protein 1Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei113PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ496A3.
PRIDEiQ496A3.

PTM databases

iPTMnetiQ496A3.
PhosphoSitePlusiQ496A3.

Expressioni

Gene expression databases

BgeeiENSG00000249481.
CleanExiHS_SPATS1.
ExpressionAtlasiQ496A3. differential.
GenevisibleiQ496A3. HS.

Organism-specific databases

HPAiHPA046230.
HPA049722.

Interactioni

Protein-protein interaction databases

BioGridi128721. 3 interactors.
IntActiQ496A3. 3 interactors.
STRINGi9606.ENSP00000424400.

Structurei

3D structure databases

ProteinModelPortaliQ496A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi69 – 75Poly-Ser7

Phylogenomic databases

eggNOGiENOG410IZX9. Eukaryota.
ENOG4112BAP. LUCA.
GeneTreeiENSGT00390000006786.
HOGENOMiHOG000154370.
HOVERGENiHBG098034.
InParanoidiQ496A3.
OMAiNWQPAVP.
OrthoDBiEOG091G0RZH.
PhylomeDBiQ496A3.
TreeFamiTF337302.

Family and domain databases

InterProiIPR029165. SASRP1.
[Graphical view]
PfamiPF15160. SASRP1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q496A3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPSMLTGNS PRGCRLPSIS STTCGRQLEK VPEKRDSGMT EVERTYSANC
60 70 80 90 100
SDFLESKGCF ANTTPSGKSV SSSSSVETGP SVSEPPGLPR VSAYVDTTAD
110 120 130 140 150
LDRKLSFSHS DHSSEMSLPE VQKDKYPEEF SLLKLQTKDG HRPEWTFYPR
160 170 180 190 200
FSSNIHTYHV GKQCFFNGVF LGNKRSLSER TVDKCFGRKK YDIDPRNGIP
210 220 230 240 250
KLTPGDNPYM YPEQSKGFHK AGSMLPPVNF SIVPYEKKFD TFIPLEPLPQ
260 270 280 290 300
IPNLPFWVKE KANSLKNEIQ EVEELDNWQP AVPLMHMLHL SGALDFPRQS
Length:300
Mass (Da):33,705
Last modified:October 23, 2007 - v2
Checksum:i20A052131D2E4D98
GO
Isoform 2 (identifier: Q496A3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:185
Mass (Da):21,527
Checksum:i3B2229331875BC27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti277N → I in AAI00957 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0366318G → R.1 PublicationCorresponds to variant rs10948132dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0287871 – 115Missing in isoform 2. 1 PublicationAdd BLAST115

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058171 mRNA. Translation: BAB71701.1.
BC100956 mRNA. Translation: AAI00957.1.
BC100957 mRNA. Translation: AAI00958.1.
BC100958 mRNA. Translation: AAI00959.1.
BC100959 mRNA. Translation: AAI00960.1.
BC110065 mRNA. Translation: AAI10066.1.
BC111414 mRNA. Translation: AAI11415.1.
CCDSiCCDS4911.1. [Q496A3-1]
RefSeqiNP_659463.1. NM_145026.3. [Q496A3-1]
UniGeneiHs.135283.

Genome annotation databases

EnsembliENST00000288390; ENSP00000424400; ENSG00000249481. [Q496A3-1]
ENST00000323108; ENSP00000437552; ENSG00000249481. [Q496A3-1]
GeneIDi221409.
KEGGihsa:221409.
UCSCiuc003oxk.4. human. [Q496A3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058171 mRNA. Translation: BAB71701.1.
BC100956 mRNA. Translation: AAI00957.1.
BC100957 mRNA. Translation: AAI00958.1.
BC100958 mRNA. Translation: AAI00959.1.
BC100959 mRNA. Translation: AAI00960.1.
BC110065 mRNA. Translation: AAI10066.1.
BC111414 mRNA. Translation: AAI11415.1.
CCDSiCCDS4911.1. [Q496A3-1]
RefSeqiNP_659463.1. NM_145026.3. [Q496A3-1]
UniGeneiHs.135283.

3D structure databases

ProteinModelPortaliQ496A3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128721. 3 interactors.
IntActiQ496A3. 3 interactors.
STRINGi9606.ENSP00000424400.

PTM databases

iPTMnetiQ496A3.
PhosphoSitePlusiQ496A3.

Polymorphism and mutation databases

BioMutaiSPATS1.

Proteomic databases

PaxDbiQ496A3.
PRIDEiQ496A3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288390; ENSP00000424400; ENSG00000249481. [Q496A3-1]
ENST00000323108; ENSP00000437552; ENSG00000249481. [Q496A3-1]
GeneIDi221409.
KEGGihsa:221409.
UCSCiuc003oxk.4. human. [Q496A3-1]

Organism-specific databases

CTDi221409.
GeneCardsiSPATS1.
HGNCiHGNC:22957. SPATS1.
HPAiHPA046230.
HPA049722.
neXtProtiNX_Q496A3.
OpenTargetsiENSG00000249481.
PharmGKBiPA134922278.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZX9. Eukaryota.
ENOG4112BAP. LUCA.
GeneTreeiENSGT00390000006786.
HOGENOMiHOG000154370.
HOVERGENiHBG098034.
InParanoidiQ496A3.
OMAiNWQPAVP.
OrthoDBiEOG091G0RZH.
PhylomeDBiQ496A3.
TreeFamiTF337302.

Miscellaneous databases

ChiTaRSiSPATS1. human.
GenomeRNAii221409.
PROiQ496A3.

Gene expression databases

BgeeiENSG00000249481.
CleanExiHS_SPATS1.
ExpressionAtlasiQ496A3. differential.
GenevisibleiQ496A3. HS.

Family and domain databases

InterProiIPR029165. SASRP1.
[Graphical view]
PfamiPF15160. SASRP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPAS1_HUMAN
AccessioniPrimary (citable) accession number: Q496A3
Secondary accession number(s): Q496A2, Q496A5, Q96LJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 30, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.