Q49689 (Y593_MYCLE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 29, 2013.
Version 91.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: UPF0051 protein ML0593 Cleaved into the following chain: | ||||
| Gene names |
| ||||
| Organism | Mycobacterium leprae (strain TN) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 272631 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium ›  |
Protein attributes
| Sequence length | 869 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Post-translational modification | This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Potential. |
| Sequence similarities | Belongs to the UPF0051 (ycf24) family. Contains 1 DOD-type homing endonuclease domain. |
Ontologies
| Keywords | |
|---|---|
| PTM | Autocatalytic cleavage Protein splicing |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | intein-mediated protein splicing Inferred from electronic annotation. Source: InterPro iron-sulfur cluster assemblyInferred from electronic annotation. Source: InterPro |
| Molecular_function | endonuclease activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 201 | 201 | UPF0051 protein ML0593, 1st part Potential | PRO_0000036187 | |||||
| Chain | 202 – 587 | 386 | Mle pps1 intein Potential | PRO_0000036188 | |||||
| Chain | 588 – 869 | 282 | UPF0051 protein ML0593, 2nd part Potential | PRO_0000036189 | |||||
Regions | |||||||||
| Domain | 344 – 477 | 134 | DOD-type homing endonuclease | ||||||
Experimental info | |||||||||
| Sequence conflict | 482 | 1 | A → R in AAA17127. Ref.1 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | Smith D.R., Robison K. Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S.  Barrell B.G.Nature 409:1007-1011(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U00013 Genomic DNA. Translation: AAA17127.1. Z99125 Genomic DNA. Translation: CAB16171.1. Z99125 Genomic DNA. Translation: CAB16172.1. AL583919 Genomic DNA. Translation: CAC30101.1. |
| PIR | A86983. S72760. |
| RefSeq | NP_301502.1. NC_002677.1. |
3D structure databases | |
| ProteinModelPortal | Q49689. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 272631.ML0593. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | CAC30101; CAC30101; CAC30101. |
| GeneID | 909370. |
| KEGG | mle:ML0593. |
| PATRIC | 18052168. VBIMycLep78757_1031. |
Organism-specific databases | |
| Leproma | ML0593. |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1372. |
| KO | K09014. |
| ProtClustDB | CLSK2460462. |
Family and domain databases | |
| Gene3D | 3.10.28.10. 1 hit. |
| InterPro | IPR003586. Hint_dom_C. IPR003587. Hint_dom_N. IPR027434. Homing_endonucl. IPR006142. INTEIN. IPR004042. Intein_endonuc. IPR006141. Intein_splice_site. IPR010231. SUF_FeS_clus_asmbl_SufB. IPR000825. SUF_FeS_clus_asmbl_SufBD. [Graphical view] |
| Pfam | PF01458. UPF0051. 1 hit. [Graphical view] |
| PRINTS | PR00379. INTEIN. |
| SMART | SM00305. HintC. 1 hit. SM00306. HintN. 1 hit. [Graphical view] |
| SUPFAM | SSF55608. SSF55608. 1 hit. |
| TIGRFAMs | TIGR01443. intein_Cterm. 1 hit. TIGR01980. sufB. 1 hit. |
| PROSITE | PS50818. INTEIN_C_TER. 1 hit. PS50819. INTEIN_ENDONUCLEASE. 1 hit. PS50817. INTEIN_N_TER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | Y593_MYCLE | ||||||||
| Accession | Primary (citable) accession number: Q49689 Secondary accession number(s): O33141 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Intein-containing proteins List of intein-containing protein entries |
| Uncharacterized protein families (UPF) List of uncharacterized protein family (UPF) entries |
| SIMILARITY comments Index of protein domains and families |