UPF0051 protein ML0593 - Mycobacterium leprae

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Q49689 (Y593_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
UPF0051 protein ML0593

Cleaved into the following chain:

Mle pps1 intein

Gene names

Ordered Locus Names:	ML0593
ORF Names:	MLCL536.28c, B1496_C2_189

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	869 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Post-translational modification

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Potential.

Sequence similarities

Belongs to the UPF0051 (ycf24) family.

Contains 1 DOD-type homing endonuclease domain.

Ontologies

Keywords
PTM	Autocatalytic cleavage Protein splicing
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	intein-mediated protein splicing Inferred from electronic annotation. Source: InterPro iron-sulfur cluster assembly Inferred from electronic annotation. Source: InterPro
Molecular function	endonuclease activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 201

201

UPF0051 protein ML0593, 1st part Potential

PRO_0000036187

Chain

202 – 587

386

Mle pps1 intein Potential

PRO_0000036188

Chain

588 – 869

282

UPF0051 protein ML0593, 2nd part Potential

PRO_0000036189

Regions

Domain

344 – 477

134

DOD-type homing endonuclease

Experimental info

Sequence conflict

482

A → R in AAA17127. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q49689 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: DB04CF70CB50765A
Show »

FASTA

869

95,573

        10         20         30         40         50         60 
MTRTSETTKS PAPELLTQQQ AIDSLGKYGY GWADSDVAGA SARRGLSEDV VRDISAKKDE 

        70         80         90        100        110        120 
PEWMLQARLK ALRVFERKPM PRWGSNLDGI DFDNIKYFVR STEKQAASWD ELPEDIRNTY 

       130        140        150        160        170        180 
DRLGIPDAEK QRLVAGVAAQ YESEVVYHQI RADLKDQGVV FLDTETGLRE YPDIFKQYLG 

       190        200        210        220        230        240 
TVIPAGDNKF SALNTAVWSG GCLTADARIN VKGKGLVSIA DVQPGDEVFG VNIGCELERG 

       250        260        270        280        290        300 
KVLAKVASGT KPVYEMHVAG RALEATGNHQ FLVARRVEEG KRTRWTAVWA PLEEIESGEP 

       310        320        330        340        350        360 
IAVARVLPDD SGTIFFSESE LDIKNRTRQC LYFPCQNSVD LLWLLGLWLG DGHTAAPHKH 

       370        380        390        400        410        420 
MRQVAFSVPA GDPVHHTAIR VVSEQFGANV TVVNCGFIVS SKAFETWLAE LGFSGDEKTK 

       430        440        450        460        470        480 
RLPAWIYSLP HEHQLALIGG LVDADGWTES SGATMSIAFA SRELLEDVRQ LAIGCGLYPD 

       490        500        510        520        530        540 
GALVERTRSA TCRDGRIVTS TSWRLRIQGS LDRVGTRTPG KRGKPVSNKG RRQRYVAAAG 

       550        560        570        580        590        600 
LNFSSLSTDT VGFARLKSKT LVGEKPTYDI QVVGLENFVA NGIVAHNSFI YVPPGVHVDI 

       610        620        630        640        650        660 
PLQAYFRINT ENMGQFERTL IIADTGSYVH YVEGCTAPIY KSDSLHSAVV EIIVKPHARV 

       670        680        690        700        710        720 
RYTTIQNWSN NVYNLVTKRA RVETGATMEW IDGNIGSKVT MKYPAVWMTG EHAKGEVLSV 

       730        740        750        760        770        780 
AFAGEGQHQD TGAKMLHLAS NTSSNIVSKS VARGGGRTSY RGLVQVNKGA HGSRSSVKCD 

       790        800        810        820        830        840 
ALLVDTISRS DTYPYVDIRE DDVTMGHEAT VSKVSENQLF YLMSRGLAED EAMAMVVRGF 

       850        860 
VEPIAKELPM EYALELNRLI ELQMEGAVG

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith D.R., Robison K. Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00013 Genomic DNA. Translation: AAA17127.1. Z99125 Genomic DNA. Translation: CAB16171.1. Z99125 Genomic DNA. Translation: CAB16172.1. AL583919 Genomic DNA. Translation: CAC30101.1.
PIR	A86983. S72760.
RefSeq	NP_301502.1. NC_002677.1.
3D structure databases
ProteinModelPortal	Q49689.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000029385; EBMYCP00000028991; EBMYCG00000029380.
GeneID	909370.
GenomeReviews	Gene locus ML0593 in contig AL450380_GR.
KEGG	mle:ML0593.
NMPDR	fig\|272631.1.peg.374.
PATRIC	18052168. VBIMycLep78757_1031.
Organism-specific databases
Leproma	ML0593.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017319.
HOGENOM	HBG129052.
ProtClustDB	CLSK2460462.
Enzyme and pathway databases
BioCyc	MLEP272631:ML0593-MONOMER.
Family and domain databases
InterPro	IPR003586. Hedgehog_hint_C. IPR003587. Hedgehog_hint_N. IPR006142. INTEIN. IPR004042. Intein_endonuc. IPR006141. Intein_splice_site. IPR010231. SUF_FeS_clus_asmbl_SufB. IPR000825. SUF_FeS_clus_asmbl_SufBD. [Graphical view]
KO	K09014.
Pfam	PF01458. UPF0051. 1 hit. [Graphical view]
PRINTS	PR00379. INTEIN.
SMART	SM00305. HintC. 1 hit. SM00306. HintN. 1 hit. [Graphical view]
TIGRFAMs	TIGR01443. Intein_Cterm. 1 hit. TIGR01980. SufB. 1 hit.
PROSITE	PS50818. INTEIN_C_TER. 1 hit. PS50819. INTEIN_ENDONUCLEASE. 1 hit. PS50817. INTEIN_N_TER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y593_MYCLE

Accession

Primary (citable) accession number: Q49689
Secondary accession number(s): O33141

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	April 27, 2001
Last modified:	January 25, 2012
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Intein-containing proteins

List of intein-containing protein entries

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Cleaved into the following chain:

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents