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Q49640

- RELA_MYCLE

UniProt

Q49640 - RELA_MYCLE

Protein

Probable GTP pyrophosphokinase

Gene

relA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp By similarity.By similarity

    Catalytic activityi

    ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

    Pathwayi

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. GTP binding Source: UniProtKB-KW
    4. GTP diphosphokinase activity Source: UniProtKB-EC
    5. kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable GTP pyrophosphokinase (EC:2.7.6.5)
    Alternative name(s):
    (p)ppGpp synthase
    ATP:GTP 3'-pyrophosphotransferase
    ppGpp synthase I
    Gene namesi
    Name:relA
    Ordered Locus Names:ML0491
    ORF Names:B1177_C1_168, MLCB1259.09
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0491.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 787787Probable GTP pyrophosphokinasePRO_0000166550Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML0491.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49640.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini102 – 19998HDAdd
    BLAST
    Domaini711 – 78575ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RelA/SpoT family.Curated
    Contains 1 ACT domain.PROSITE-ProRule annotation
    Contains 1 HD domain.Curated

    Phylogenomic databases

    eggNOGiCOG0317.
    HOGENOMiHOG000018301.
    KOiK00951.
    OMAiIGYITRG.
    OrthoDBiEOG6SV551.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR002912. ACT_dom.
    IPR012675. Beta-grasp_dom.
    IPR003607. HD/PDEase_dom.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view]
    PfamiPF01842. ACT. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view]
    SMARTiSM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view]
    SUPFAMiSSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q49640-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADDQGTAQA LQPVQVVPGP AVEAPETPVE TLKTSSSASR RVRARLARRM    50
    TAQRSTISPV LEPLVAVHKE FYPKANLSIV QRAFEVADQR HASQLRRSGD 100
    PYITHPLAVA NILAELGMDI TTLVAALLHD TVEDTGYTLE ALSEEFGDEV 150
    GHLVDGVTKL DRVVLGSAAE GETIRKMITA MARDPRVLVI KVADRLHNMR 200
    TMRFLPPEKQ ARKARETLEV IAPLAHRLGM ASVKWELEDL SFAILHPKKY 250
    EEIVRLVAGR APSRDTYLAK VRAEIISTLG ASKIKATVEG RPKHYWSIYQ 300
    KMIVKGRDFD DIHDLVGIRI LCDEIRDCYA AVGVVHSLWQ PMAGRFKDYI 350
    AQPRYGVYQS LHTTVVGPEG KPLEVQIRTR DMHRTAEYGI AAHWRYKEAK 400
    GRNGVLHPHA AAEIDDMAWM RQLLDWQREA AEPGEFLESL RYDLAVQEIF 450
    VFTPKGDVIT LPTGSTPVDF AYAVHTEVGH RCIGARVNGR LVALERKLEN 500
    GEFVEIFTSK APNAGPSRDW QQFVVSPRAK TKIRQWFAKE RREEALEAGK 550
    DAMAREVRRG GLPLQRLVNG ESMAAVAREL HYIDVSALYT AIGEGHVSAR 600
    HVVQRLLAEL GGIDQAEEEL AERSTPTTML RRQRSTDDVG VSVPGAPGVL 650
    TKLAKCCTPV PGDAIMGFVT RGGGVSVHRT DCTNTASLQQ QAERIIEVLW 700
    APSSSSVFLV AIQVEALDRH RLLLDITRAL ADERVDILSA SVTTSGDRVA 750
    ISRFTFEMGD PKHLGHLLNV VRNVEGVYDV YRVMSAS 787
    Length:787
    Mass (Da):87,266
    Last modified:November 1, 1997 - v1
    Checksum:iDE2EB784AA9EF061
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00011 Genomic DNA. Translation: AAA17089.1.
    AL023591 Genomic DNA. Translation: CAA19084.1.
    AL583918 Genomic DNA. Translation: CAC29999.1.
    PIRiS72725.
    RefSeqiNP_301430.1. NC_002677.1.
    WP_010907754.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC29999; CAC29999; CAC29999.
    GeneIDi909244.
    KEGGimle:ML0491.
    PATRICi18051816. VBIMycLep78757_0855.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00011 Genomic DNA. Translation: AAA17089.1 .
    AL023591 Genomic DNA. Translation: CAA19084.1 .
    AL583918 Genomic DNA. Translation: CAC29999.1 .
    PIRi S72725.
    RefSeqi NP_301430.1. NC_002677.1.
    WP_010907754.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q49640.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0491.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC29999 ; CAC29999 ; CAC29999 .
    GeneIDi 909244.
    KEGGi mle:ML0491.
    PATRICi 18051816. VBIMycLep78757_0855.

    Organism-specific databases

    Lepromai ML0491.

    Phylogenomic databases

    eggNOGi COG0317.
    HOGENOMi HOG000018301.
    KOi K00951.
    OMAi IGYITRG.
    OrthoDBi EOG6SV551.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR002912. ACT_dom.
    IPR012675. Beta-grasp_dom.
    IPR003607. HD/PDEase_dom.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view ]
    Pfami PF01842. ACT. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view ]
    SMARTi SM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Smith D.R., Robison K.
      Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiRELA_MYCLE
    AccessioniPrimary (citable) accession number: Q49640
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3