SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q49640

- RELA_MYCLE

UniProt

Q49640 - RELA_MYCLE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable GTP pyrophosphokinase
Gene
relA, ML0491, B1177_C1_168, MLCB1259.09
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp By similarity.

Catalytic activityi

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. GTP diphosphokinase activity Source: UniProtKB-EC
  4. amino acid binding Source: InterPro
  5. kinase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable GTP pyrophosphokinase (EC:2.7.6.5)
Alternative name(s):
(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I
Gene namesi
Name:relA
Ordered Locus Names:ML0491
ORF Names:B1177_C1_168, MLCB1259.09
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 787787Probable GTP pyrophosphokinase
PRO_0000166550Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0491.

Structurei

3D structure databases

ProteinModelPortaliQ49640.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 19998HD
Add
BLAST
Domaini711 – 78575ACT
Add
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.
Contains 1 ACT domain.
Contains 1 HD domain.

Phylogenomic databases

eggNOGiCOG0317.
HOGENOMiHOG000018301.
KOiK00951.
OMAiIGYITRG.
OrthoDBiEOG6SV551.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49640-1 [UniParc]FASTAAdd to Basket

« Hide

MADDQGTAQA LQPVQVVPGP AVEAPETPVE TLKTSSSASR RVRARLARRM    50
TAQRSTISPV LEPLVAVHKE FYPKANLSIV QRAFEVADQR HASQLRRSGD 100
PYITHPLAVA NILAELGMDI TTLVAALLHD TVEDTGYTLE ALSEEFGDEV 150
GHLVDGVTKL DRVVLGSAAE GETIRKMITA MARDPRVLVI KVADRLHNMR 200
TMRFLPPEKQ ARKARETLEV IAPLAHRLGM ASVKWELEDL SFAILHPKKY 250
EEIVRLVAGR APSRDTYLAK VRAEIISTLG ASKIKATVEG RPKHYWSIYQ 300
KMIVKGRDFD DIHDLVGIRI LCDEIRDCYA AVGVVHSLWQ PMAGRFKDYI 350
AQPRYGVYQS LHTTVVGPEG KPLEVQIRTR DMHRTAEYGI AAHWRYKEAK 400
GRNGVLHPHA AAEIDDMAWM RQLLDWQREA AEPGEFLESL RYDLAVQEIF 450
VFTPKGDVIT LPTGSTPVDF AYAVHTEVGH RCIGARVNGR LVALERKLEN 500
GEFVEIFTSK APNAGPSRDW QQFVVSPRAK TKIRQWFAKE RREEALEAGK 550
DAMAREVRRG GLPLQRLVNG ESMAAVAREL HYIDVSALYT AIGEGHVSAR 600
HVVQRLLAEL GGIDQAEEEL AERSTPTTML RRQRSTDDVG VSVPGAPGVL 650
TKLAKCCTPV PGDAIMGFVT RGGGVSVHRT DCTNTASLQQ QAERIIEVLW 700
APSSSSVFLV AIQVEALDRH RLLLDITRAL ADERVDILSA SVTTSGDRVA 750
ISRFTFEMGD PKHLGHLLNV VRNVEGVYDV YRVMSAS 787
Length:787
Mass (Da):87,266
Last modified:November 1, 1997 - v1
Checksum:iDE2EB784AA9EF061
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00011 Genomic DNA. Translation: AAA17089.1.
AL023591 Genomic DNA. Translation: CAA19084.1.
AL583918 Genomic DNA. Translation: CAC29999.1.
PIRiS72725.
RefSeqiNP_301430.1. NC_002677.1.
WP_010907754.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29999; CAC29999; CAC29999.
GeneIDi909244.
KEGGimle:ML0491.
PATRICi18051816. VBIMycLep78757_0855.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00011 Genomic DNA. Translation: AAA17089.1 .
AL023591 Genomic DNA. Translation: CAA19084.1 .
AL583918 Genomic DNA. Translation: CAC29999.1 .
PIRi S72725.
RefSeqi NP_301430.1. NC_002677.1.
WP_010907754.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q49640.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272631.ML0491.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC29999 ; CAC29999 ; CAC29999 .
GeneIDi 909244.
KEGGi mle:ML0491.
PATRICi 18051816. VBIMycLep78757_0855.

Organism-specific databases

Lepromai ML0491.

Phylogenomic databases

eggNOGi COG0317.
HOGENOMi HOG000018301.
KOi K00951.
OMAi IGYITRG.
OrthoDBi EOG6SV551.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiRELA_MYCLE
AccessioniPrimary (citable) accession number: Q49640
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi