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Q49640

- RELA_MYCLE

UniProt

Q49640 - RELA_MYCLE

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Protein

Probable GTP pyrophosphokinase

Gene

relA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity).By similarity

Catalytic activityi

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. GTP binding Source: UniProtKB-KW
  4. GTP diphosphokinase activity Source: UniProtKB-EC
  5. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable GTP pyrophosphokinase (EC:2.7.6.5)
Alternative name(s):
(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I
Gene namesi
Name:relA
Ordered Locus Names:ML0491
ORF Names:B1177_C1_168, MLCB1259.09
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 787787Probable GTP pyrophosphokinasePRO_0000166550Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0491.

Structurei

3D structure databases

ProteinModelPortaliQ49640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 19998HDAdd
BLAST
Domaini711 – 78575ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.Curated
Contains 1 ACT domain.PROSITE-ProRule annotation
Contains 1 HD domain.Curated

Phylogenomic databases

eggNOGiCOG0317.
HOGENOMiHOG000018301.
KOiK00951.
OMAiIGYITRG.
OrthoDBiEOG6SV551.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49640-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADDQGTAQA LQPVQVVPGP AVEAPETPVE TLKTSSSASR RVRARLARRM
60 70 80 90 100
TAQRSTISPV LEPLVAVHKE FYPKANLSIV QRAFEVADQR HASQLRRSGD
110 120 130 140 150
PYITHPLAVA NILAELGMDI TTLVAALLHD TVEDTGYTLE ALSEEFGDEV
160 170 180 190 200
GHLVDGVTKL DRVVLGSAAE GETIRKMITA MARDPRVLVI KVADRLHNMR
210 220 230 240 250
TMRFLPPEKQ ARKARETLEV IAPLAHRLGM ASVKWELEDL SFAILHPKKY
260 270 280 290 300
EEIVRLVAGR APSRDTYLAK VRAEIISTLG ASKIKATVEG RPKHYWSIYQ
310 320 330 340 350
KMIVKGRDFD DIHDLVGIRI LCDEIRDCYA AVGVVHSLWQ PMAGRFKDYI
360 370 380 390 400
AQPRYGVYQS LHTTVVGPEG KPLEVQIRTR DMHRTAEYGI AAHWRYKEAK
410 420 430 440 450
GRNGVLHPHA AAEIDDMAWM RQLLDWQREA AEPGEFLESL RYDLAVQEIF
460 470 480 490 500
VFTPKGDVIT LPTGSTPVDF AYAVHTEVGH RCIGARVNGR LVALERKLEN
510 520 530 540 550
GEFVEIFTSK APNAGPSRDW QQFVVSPRAK TKIRQWFAKE RREEALEAGK
560 570 580 590 600
DAMAREVRRG GLPLQRLVNG ESMAAVAREL HYIDVSALYT AIGEGHVSAR
610 620 630 640 650
HVVQRLLAEL GGIDQAEEEL AERSTPTTML RRQRSTDDVG VSVPGAPGVL
660 670 680 690 700
TKLAKCCTPV PGDAIMGFVT RGGGVSVHRT DCTNTASLQQ QAERIIEVLW
710 720 730 740 750
APSSSSVFLV AIQVEALDRH RLLLDITRAL ADERVDILSA SVTTSGDRVA
760 770 780
ISRFTFEMGD PKHLGHLLNV VRNVEGVYDV YRVMSAS
Length:787
Mass (Da):87,266
Last modified:November 1, 1997 - v1
Checksum:iDE2EB784AA9EF061
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00011 Genomic DNA. Translation: AAA17089.1.
AL023591 Genomic DNA. Translation: CAA19084.1.
AL583918 Genomic DNA. Translation: CAC29999.1.
PIRiS72725.
RefSeqiNP_301430.1. NC_002677.1.
WP_010907754.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29999; CAC29999; CAC29999.
GeneIDi909244.
KEGGimle:ML0491.
PATRICi18051816. VBIMycLep78757_0855.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00011 Genomic DNA. Translation: AAA17089.1 .
AL023591 Genomic DNA. Translation: CAA19084.1 .
AL583918 Genomic DNA. Translation: CAC29999.1 .
PIRi S72725.
RefSeqi NP_301430.1. NC_002677.1.
WP_010907754.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q49640.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0491.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC29999 ; CAC29999 ; CAC29999 .
GeneIDi 909244.
KEGGi mle:ML0491.
PATRICi 18051816. VBIMycLep78757_0855.

Organism-specific databases

Lepromai ML0491.

Phylogenomic databases

eggNOGi COG0317.
HOGENOMi HOG000018301.
KOi K00951.
OMAi IGYITRG.
OrthoDBi EOG6SV551.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiRELA_MYCLE
AccessioniPrimary (citable) accession number: Q49640
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 1, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3