Reviewed,
UniProtKB/Swiss-Prot Q49611 (FWDG_METKA)
Last modified
February 9, 2010.
Version 71.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tungsten-containing formylmethanofuran dehydrogenase 2 subunit G EC=1.2.99.5 Alternative name(s): Tungsten-containing formylmethanofuran dehydrogenase II subunit G | ||||||
| Gene names |
| ||||||
| Organism | Methanopyrus kandleri [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 2320 [NCBI] | ||||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus |
Protein attributes
| Sequence length | 79 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the reversible oxidation of CO2 and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile. May function as an electron transfer protein By similarity. |
| Catalytic activity | Formylmethanofuran + H2O + acceptor = CO2 + methanofuran + reduced acceptor. |
| Cofactor | Binds 2 4Fe-4S clusters Potential. |
| Enzyme regulation | Not inactivated by cyanide By similarity. |
| Pathway | |
| Induction | By growth on tungsten or molybdenum under anaerobic conditions. |
| Sequence similarities | Contains 2 4Fe-4S ferredoxin-type domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Electron transport Methanogenesis Transport |
| Domain | Repeat |
| Ligand | 4Fe-4S Iron Iron-sulfur Metal-binding |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW methanogenesisInferred from electronic annotation. Source: UniProtKB-KW transportInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activityInferred from electronic annotation. Source: InterPro formylmethanofuran dehydrogenase activityInferred from electronic annotation. Source: EC iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 79 | 79 | Tungsten-containing formylmethanofuran dehydrogenase 2 subunit G | PRO_0000159254 | |||||
Regions | |||||||||
| Domain | 2 – 31 | 30 | 4Fe-4S ferredoxin-type 1 | ||||||
| Domain | 51 – 79 | 29 | 4Fe-4S ferredoxin-type 2 | ||||||
Sites | |||||||||
| Metal binding | 11 | 1 | Iron-sulfur 1 (4Fe-4S) By similarity | ||||||
| Metal binding | 14 | 1 | Iron-sulfur 1 (4Fe-4S) By similarity | ||||||
| Metal binding | 17 | 1 | Iron-sulfur 1 (4Fe-4S) By similarity | ||||||
| Metal binding | 21 | 1 | Iron-sulfur 2 (4Fe-4S) By similarity | ||||||
| Metal binding | 60 | 1 | Iron-sulfur 2 (4Fe-4S) By similarity | ||||||
| Metal binding | 63 | 1 | Iron-sulfur 2 (4Fe-4S) By similarity | ||||||
| Metal binding | 66 | 1 | Iron-sulfur 2 (4Fe-4S) By similarity | ||||||
| Metal binding | 70 | 1 | Iron-sulfur 1 (4Fe-4S) By similarity | ||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "A selenium-dependent and a selenium-independent formylmethanofuran dehydrogenase and their transcriptional regulation in the hyperthermophilic Methanopyrus kandleri." Vorholt J.A., Vaupel M., Thauer R.K. Mol. Microbiol. 23:1033-1042(1997) [PubMed: 9076739] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938. |
| [2] | "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens." Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A. Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed: 11930014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X98917 Genomic DNA. Translation: CAA67417.1. AE009439 Genomic DNA. Translation: AAM02738.1. |
| RefSeq | NP_614808.1. |
3D structure databases | |
| SMR | Q49611. Positions 6-79. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1478120. |
| GenomeReviews | Gene locus MK1525 in contig AE009439_GR. |
| KEGG | mka:MK1525. |
| NMPDR | fig|190192.1.peg.1521. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG734156. |
| OMA | IACPVNA. |
Enzyme and pathway databases | |
| BioCyc | MKAN190192:MK1525-MONOMER. |
| BRENDA | 1.2.99.5. 7577. |
Family and domain databases | |
| InterPro | IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. [Graphical view] |
| PROSITE | PS00198. 4FE4S_FER_1. 2 hits. PS51379. 4FE4S_FER_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FWDG_METKA | ||||||||
| Accession | Primary (citable) accession number: Q49611 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


