ID   MTRE_METKA              Reviewed;         298 AA.
AC   Q49606;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   16-JUN-2009, entry version 56.
DE   RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit E;
DE            EC=2.1.1.86;
DE   AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E;
GN   Name=mtrE; OrderedLocusNames=MK0656;
OS   Methanopyrus kandleri.
OC   Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae;
OC   Methanopyrus.
OX   NCBI_TaxID=2320;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=98121200; PubMed=9461302;
RX   DOI=10.1111/j.1432-1033.1997.00783.x;
RA   Harms U., Thauer R.K.;
RT   "Identification of the active site histidine in the corrinoid protein
RT   MtrA of the energy-conserving methyltransferase complex from
RT   Methanobacterium thermoautotrophicum.";
RL   Eur. J. Biochem. 250:783-788(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938;
RX   MEDLINE=21927647; PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L.,
RA   Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O.,
RA   Malykh A.G., Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19
RT   and monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-89.
RX   MEDLINE=97016827; PubMed=8863453;
RA   Noelling J., Elfner A., Palmer J.R., Steigerwald V.J., Pihl T.D.,
RA   Lake J.A., Reeve J.N.;
RT   "Phylogeny of Methanopyrus kandleri based on methyl coenzyme M
RT   reductase operons.";
RL   Int. J. Syst. Bacteriol. 46:1170-1173(1996).
CC   -!- FUNCTION: Part of a complex that catalyzes the formation of
CC       methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and
CC       methyl-tetrahydromethanopterin. This is an energy-conserving,
CC       sodium-ion translocating step (By similarity).
CC   -!- CATALYTIC ACTIVITY: 5-methyl-5,6,7,8-tetrahydromethanopterin + 2-
CC       mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-
CC       (methylthio)ethanesulfonate.
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from carbone
CC       dioxide; methyl-CoM from 5,10-methylene-H(4)MPT: step 2/2.
CC   -!- SUBUNIT: The complex is composed of 8 subunits; mtrA, mtrB, mtrC,
CC       mtrD, mtrE, mtrF, mtrG and mtrH (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the mtrE family.
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DR   EMBL; Y14428; CAA74774.1; -; Genomic_DNA.
DR   EMBL; AE010359; AAM01871.1; -; Genomic_DNA.
DR   EMBL; U57340; AAB02004.1; -; Genomic_DNA.
DR   RefSeq; NP_613941.1; -.
DR   GeneID; 1476757; -.
DR   GenomeReviews; AE009439_GR; MK0656.
DR   KEGG; mka:MK0656; -.
DR   NMPDR; fig|190192.1.peg.654; -.
DR   HOGENOM; Q49606; -.
DR   OMA; Q49606; SNPNSQV.
DR   BioCyc; MKAN190192:MK0656-MON; -.
DR   BRENDA; 2.1.1.86; 7577.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0012506; C:vesicle membrane; IEA:InterPro.
DR   GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase...; IEA:HAMAP.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   HAMAP; MF_01098; -; 1.
DR   InterPro; IPR005780; MeTrfase_E.
DR   Pfam; PF04206; MtrE; 1.
DR   PIRSF; PIRSF016509; MtrE; 1.
DR   TIGRFAMs; TIGR01113; mtrE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Membrane; Methanogenesis;
KW   Methyltransferase; One-carbon metabolism; Transferase; Transmembrane.
FT   CHAIN         1    298       Tetrahydromethanopterin S-
FT                                methyltransferase subunit E.
FT                                /FTId=PRO_0000147540.
FT   TRANSMEM      3     23       Potential.
FT   TRANSMEM     59     79       Potential.
FT   TRANSMEM     84    104       Potential.
FT   TRANSMEM    132    152       Potential.
FT   TRANSMEM    160    180       Potential.
FT   TRANSMEM    230    250       Potential.
FT   TRANSMEM    251    271       Potential.
SQ   SEQUENCE   298 AA;  31527 MW;  B540A568D1168C4C CRC64;
     MVGFTEIGLA AAMGALATIA GAFEDAESDV GSQSNPNSQV QLAPQMMNFH RYFNKAISGE
     PVSYMLYGAI AGTVTWVMMT KFGLPFLAAA AVGVGVNALI HMVFATTAHL GRMASAAEFG
     HPIYLDVVLS HLGPIAGFGG IATFAIVSLA YIQWALLKHP FPLPLLAALW GVTVGAIGSS
     TGDVHYGAER LYQHYPFGGG VPVAAHGNIT RKAETGIRNS MDSVYFCAKF GNPLTGLCFG
     LVVFFSTWAG LFGQWGAVIA MGLVTLGCLI VSNRVEKKAR ESYGTYEDVE MDEICDPV
//