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Protein

Speedy protein E2

Gene

SPDYE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Speedy protein E2
Gene namesi
Name:SPDYE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:33841. SPDYE2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726233.

Polymorphism and mutation databases

BioMutaiSPDYE2.
DMDMi308153503.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Speedy protein E2PRO_0000332292Add
BLAST

Proteomic databases

PaxDbiQ495Y8.
PRIDEiQ495Y8.

Expressioni

Gene expression databases

BgeeiQ495Y8.
ExpressionAtlasiQ495Y8. baseline.

Organism-specific databases

HPAiHPA044799.
HPA051750.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAPRE1Q156913EBI-10241662,EBI-1004115

Protein-protein interaction databases

BioGridi137321. 1 interaction.
IntActiQ495Y8. 1 interaction.
STRINGi9606.ENSP00000421686.

Structurei

3D structure databases

ProteinModelPortaliQ495Y8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi275 – 36389Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the Speedy/Ringo family.Curated

Phylogenomic databases

eggNOGiNOG26741.
GeneTreeiENSGT00420000029723.
HOGENOMiHOG000132466.
HOVERGENiHBG056095.
InParanoidiQ495Y8.
OMAiCKRGQIT.
OrthoDBiEOG700895.
PhylomeDBiQ495Y8.
TreeFamiTF329827.

Family and domain databases

InterProiIPR020984. Speedy.
[Graphical view]
PfamiPF11357. Spy1. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q495Y8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRTETRFRK RGQITGKITT SRQPHPQNEQ SPQRSTSGYP LQEVVDDEML
60 70 80 90 100
GPSAPGVDPS PPCRSLGWKR KREWSDESEE EPEKELAPEP EETWVVEMLC
110 120 130 140 150
GLKMKLKQQR VSPILPEHHK DFNSQLAPGV DPSPPHRSFC WKRKMEWWDE
160 170 180 190 200
SEESLEEEPR KVLAPEPEEI WVAEMLCGLK MKLKRRRVSL VLPEHHEAFN
210 220 230 240 250
RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGFPS WQYQRIHFFL
260 270 280 290 300
ALYLANDMEE DDEDSKQNIF HFLYRKNRSR IPLLRKPWFQ LGHSMNPRAR
310 320 330 340 350
KNRSRIPLLR KRRFQLYRST NPRARKNRSR IPLLRKRRFQ LYRSMNSRAR
360 370 380 390 400
KNRSQIVLFQ KRRFHFFCSM SCRAWVSPEE LEEIQAYDPE HWVWARDRAH

LS
Note: No experimental confirmation available.
Length:402
Mass (Da):48,300
Last modified:October 5, 2010 - v2
Checksum:iA3B1FEEA1A59A85D
GO
Isoform 2 (identifier: Q495Y8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.

Note: No experimental confirmation available.
Show »
Length:258
Mass (Da):31,722
Checksum:i20511D2FA8F71DDF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301V → L in BAG63573 (PubMed:14702039).Curated
Sequence conflicti287 – 2871P → R in BAG63573 (PubMed:14702039).Curated
Sequence conflicti287 – 2871P → R in AAI00974 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 144144Missing in isoform 2. 1 PublicationVSP_039851Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302217 mRNA. Translation: BAG63573.1.
AC093668 Genomic DNA. No translation available.
BC100973 mRNA. Translation: AAI00974.1.
CCDSiCCDS34716.2. [Q495Y8-1]
RefSeqiNP_001026789.2. NM_001031618.3. [Q495Y8-1]
XP_006716061.1. XM_006715998.2. [Q495Y8-1]
UniGeneiHs.656428.

Genome annotation databases

EnsembliENST00000341656; ENSP00000342628; ENSG00000205238. [Q495Y8-2]
ENST00000432940; ENSP00000395689; ENSG00000205238. [Q495Y8-1]
ENST00000507918; ENSP00000421686; ENSG00000205238. [Q495Y8-1]
GeneIDi441273.
KEGGihsa:441273.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302217 mRNA. Translation: BAG63573.1.
AC093668 Genomic DNA. No translation available.
BC100973 mRNA. Translation: AAI00974.1.
CCDSiCCDS34716.2. [Q495Y8-1]
RefSeqiNP_001026789.2. NM_001031618.3. [Q495Y8-1]
XP_006716061.1. XM_006715998.2. [Q495Y8-1]
UniGeneiHs.656428.

3D structure databases

ProteinModelPortaliQ495Y8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137321. 1 interaction.
IntActiQ495Y8. 1 interaction.
STRINGi9606.ENSP00000421686.

Polymorphism and mutation databases

BioMutaiSPDYE2.
DMDMi308153503.

Proteomic databases

PaxDbiQ495Y8.
PRIDEiQ495Y8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341656; ENSP00000342628; ENSG00000205238. [Q495Y8-2]
ENST00000432940; ENSP00000395689; ENSG00000205238. [Q495Y8-1]
ENST00000507918; ENSP00000421686; ENSG00000205238. [Q495Y8-1]
GeneIDi441273.
KEGGihsa:441273.

Organism-specific databases

CTDi441273.
GeneCardsiGC07P102191.
HGNCiHGNC:33841. SPDYE2.
HPAiHPA044799.
HPA051750.
neXtProtiNX_Q495Y8.
PharmGKBiPA164726233.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG26741.
GeneTreeiENSGT00420000029723.
HOGENOMiHOG000132466.
HOVERGENiHBG056095.
InParanoidiQ495Y8.
OMAiCKRGQIT.
OrthoDBiEOG700895.
PhylomeDBiQ495Y8.
TreeFamiTF329827.

Miscellaneous databases

GenomeRNAii441273.
NextBioi109996.
PROiQ495Y8.

Gene expression databases

BgeeiQ495Y8.
ExpressionAtlasiQ495Y8. baseline.

Family and domain databases

InterProiIPR020984. Speedy.
[Graphical view]
PfamiPF11357. Spy1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiSPDE2_HUMAN
AccessioniPrimary (citable) accession number: Q495Y8
Secondary accession number(s): B4DY11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 5, 2010
Last modified: June 24, 2015
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.