Q495Y8 (SPDE2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Speedy protein E2

Gene names

Name:

SPDYE2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the Speedy/Ringo family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q495Y8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q495Y8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	Speedy protein E2		PRO_0000332292
Regions
	Compositional bias	275 – 363	89	Arg-rich
Natural variations
	Alternative sequence	1 – 144	144	Missing in isoform 2.		VSP_039851
Experimental info
	Sequence conflict	130	1	V → L in BAG63573. Ref.1
	Sequence conflict	287	1	P → R in BAG63573. Ref.1
	Sequence conflict	287	1	P → R in AAI00974. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 2. Checksum: A3B1FEEA1A59A85D	FASTA	402	48,300
	10 20 30 40 50 60 MDRTETRFRK RGQITGKITT SRQPHPQNEQ SPQRSTSGYP LQEVVDDEML GPSAPGVDPS 70 80 90 100 110 120 PPCRSLGWKR KREWSDESEE EPEKELAPEP EETWVVEMLC GLKMKLKQQR VSPILPEHHK 130 140 150 160 170 180 DFNSQLAPGV DPSPPHRSFC WKRKMEWWDE SEESLEEEPR KVLAPEPEEI WVAEMLCGLK 190 200 210 220 230 240 MKLKRRRVSL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGFPS 250 260 270 280 290 300 WQYQRIHFFL ALYLANDMEE DDEDSKQNIF HFLYRKNRSR IPLLRKPWFQ LGHSMNPRAR 310 320 330 340 350 360 KNRSRIPLLR KRRFQLYRST NPRARKNRSR IPLLRKRRFQ LYRSMNSRAR KNRSQIVLFQ 370 380 390 400 KRRFHFFCSM SCRAWVSPEE LEEIQAYDPE HWVWARDRAH LS
	Isoform 2 [UniParc]. Checksum: 20511D2FA8F71DDF	FASTA	258	31,722
	10 20 30 40 50 60 MEWWDESEES LEEEPRKVLA PEPEEIWVAE MLCGLKMKLK RRRVSLVLPE HHEAFNRLLE 70 80 90 100 110 120 DPVIKRFLAW DKDLRVSDKY LLAMVIAYFS RAGFPSWQYQ RIHFFLALYL ANDMEEDDED 130 140 150 160 170 180 SKQNIFHFLY RKNRSRIPLL RKPWFQLGHS MNPRARKNRS RIPLLRKRRF QLYRSTNPRA 190 200 210 220 230 240 RKNRSRIPLL RKRRFQLYRS MNSRARKNRS QIVLFQKRRF HFFCSMSCRA WVSPEELEEI 250 QAYDPEHWVW ARDRAHLS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK302217 mRNA. Translation: BAG63573.1. AC093668 Genomic DNA. No translation available. BC100973 mRNA. Translation: AAI00974.1.
IPI	IPI00930539. IPI00941436.
RefSeq	NP_001026789.2. NM_001031618.3.
UniGene	Hs.656428.
3D structure databases
ProteinModelPortal	Q495Y8.
ModBase	Search...
Polymorphism databases
DMDM	308153503.
Proteomic databases
PaxDb	Q495Y8.
PRIDE	Q495Y8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341656; ENSP00000342628; ENSG00000205238. ENST00000432940; ENSP00000395689; ENSG00000205238. ENST00000507918; ENSP00000421686; ENSG00000205238.
GeneID	441273.
KEGG	hsa:441273.
Organism-specific databases
CTD	441273.
GeneCards	GC07P102191.
HGNC	HGNC:33841. SPDYE2.
neXtProt	NX_Q495Y8.
PharmGKB	PA164726233.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG26741.
HOGENOM	HOG000132466.
HOVERGEN	HBG056095.
InParanoid	Q495Y8.
OMA	CKRGQIT.
OrthoDB	EOG4N04G0.
Gene expression databases
ArrayExpress	Q495Y8.
Bgee	Q495Y8.
Genevestigator	Q495Y8.
Family and domain databases
InterPro	IPR020984. Cell_cycle_regulatory_Spy1. [Graphical view]
Pfam	PF11357. Spy1. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	441273.
NextBio	109996.

Entry information

Entry name

SPDE2_HUMAN

Accession

Primary (citable) accession number: Q495Y8
Secondary accession number(s): B4DY11

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	October 5, 2010
Last modified:	April 3, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.