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Q495Y8

- SPDE2_HUMAN

UniProt

Q495Y8 - SPDE2_HUMAN

Protein

Speedy protein E2

Gene

SPDYE2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Speedy protein E2
    Gene namesi
    Name:SPDYE2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:33841. SPDYE2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164726233.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 402402Speedy protein E2PRO_0000332292Add
    BLAST

    Proteomic databases

    PaxDbiQ495Y8.
    PRIDEiQ495Y8.

    Expressioni

    Gene expression databases

    BgeeiQ495Y8.
    GenevestigatoriQ495Y8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ495Y8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi275 – 36389Arg-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Speedy/Ringo family.Curated

    Phylogenomic databases

    eggNOGiNOG26741.
    HOGENOMiHOG000132466.
    HOVERGENiHBG056095.
    InParanoidiQ495Y8.
    OMAiCKRGQIT.
    OrthoDBiEOG700895.
    PhylomeDBiQ495Y8.
    TreeFamiTF329827.

    Family and domain databases

    InterProiIPR020984. Cell_cycle_regulatory_Spy1.
    [Graphical view]
    PfamiPF11357. Spy1. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q495Y8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDRTETRFRK RGQITGKITT SRQPHPQNEQ SPQRSTSGYP LQEVVDDEML    50
    GPSAPGVDPS PPCRSLGWKR KREWSDESEE EPEKELAPEP EETWVVEMLC 100
    GLKMKLKQQR VSPILPEHHK DFNSQLAPGV DPSPPHRSFC WKRKMEWWDE 150
    SEESLEEEPR KVLAPEPEEI WVAEMLCGLK MKLKRRRVSL VLPEHHEAFN 200
    RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGFPS WQYQRIHFFL 250
    ALYLANDMEE DDEDSKQNIF HFLYRKNRSR IPLLRKPWFQ LGHSMNPRAR 300
    KNRSRIPLLR KRRFQLYRST NPRARKNRSR IPLLRKRRFQ LYRSMNSRAR 350
    KNRSQIVLFQ KRRFHFFCSM SCRAWVSPEE LEEIQAYDPE HWVWARDRAH 400
    LS 402

    Note: No experimental confirmation available.

    Length:402
    Mass (Da):48,300
    Last modified:October 5, 2010 - v2
    Checksum:iA3B1FEEA1A59A85D
    GO
    Isoform 2 (identifier: Q495Y8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-144: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:258
    Mass (Da):31,722
    Checksum:i20511D2FA8F71DDF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti130 – 1301V → L in BAG63573. (PubMed:14702039)Curated
    Sequence conflicti287 – 2871P → R in BAG63573. (PubMed:14702039)Curated
    Sequence conflicti287 – 2871P → R in AAI00974. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 144144Missing in isoform 2. 1 PublicationVSP_039851Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK302217 mRNA. Translation: BAG63573.1.
    AC093668 Genomic DNA. No translation available.
    BC100973 mRNA. Translation: AAI00974.1.
    CCDSiCCDS34716.2. [Q495Y8-1]
    RefSeqiNP_001026789.2. NM_001031618.3. [Q495Y8-1]
    XP_006716061.1. XM_006715998.1. [Q495Y8-1]
    UniGeneiHs.656428.

    Genome annotation databases

    EnsembliENST00000341656; ENSP00000342628; ENSG00000205238. [Q495Y8-2]
    ENST00000432940; ENSP00000395689; ENSG00000205238. [Q495Y8-2]
    ENST00000507918; ENSP00000421686; ENSG00000205238. [Q495Y8-1]
    GeneIDi441273.
    KEGGihsa:441273.

    Polymorphism databases

    DMDMi308153503.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK302217 mRNA. Translation: BAG63573.1 .
    AC093668 Genomic DNA. No translation available.
    BC100973 mRNA. Translation: AAI00974.1 .
    CCDSi CCDS34716.2. [Q495Y8-1 ]
    RefSeqi NP_001026789.2. NM_001031618.3. [Q495Y8-1 ]
    XP_006716061.1. XM_006715998.1. [Q495Y8-1 ]
    UniGenei Hs.656428.

    3D structure databases

    ProteinModelPortali Q495Y8.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 308153503.

    Proteomic databases

    PaxDbi Q495Y8.
    PRIDEi Q495Y8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341656 ; ENSP00000342628 ; ENSG00000205238 . [Q495Y8-2 ]
    ENST00000432940 ; ENSP00000395689 ; ENSG00000205238 . [Q495Y8-2 ]
    ENST00000507918 ; ENSP00000421686 ; ENSG00000205238 . [Q495Y8-1 ]
    GeneIDi 441273.
    KEGGi hsa:441273.

    Organism-specific databases

    CTDi 441273.
    GeneCardsi GC07P102191.
    HGNCi HGNC:33841. SPDYE2.
    neXtProti NX_Q495Y8.
    PharmGKBi PA164726233.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26741.
    HOGENOMi HOG000132466.
    HOVERGENi HBG056095.
    InParanoidi Q495Y8.
    OMAi CKRGQIT.
    OrthoDBi EOG700895.
    PhylomeDBi Q495Y8.
    TreeFami TF329827.

    Miscellaneous databases

    GenomeRNAii 441273.
    NextBioi 109996.
    PROi Q495Y8.

    Gene expression databases

    Bgeei Q495Y8.
    Genevestigatori Q495Y8.

    Family and domain databases

    InterProi IPR020984. Cell_cycle_regulatory_Spy1.
    [Graphical view ]
    Pfami PF11357. Spy1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiSPDE2_HUMAN
    AccessioniPrimary (citable) accession number: Q495Y8
    Secondary accession number(s): B4DY11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3