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Protein

Tripartite motif-containing protein 60

Gene

TRIM60

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri92 – 133B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 60
Alternative name(s):
RING finger protein 129
RING finger protein 33
Gene namesi
Name:TRIM60
Synonyms:RNF129, RNF33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000176979.12
HGNCiHGNC:21162 TRIM60
neXtProtiNX_Q495X7

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176979
PharmGKBiPA134909634

Polymorphism and mutation databases

BioMutaiTRIM60
DMDMi114154820

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002491891 – 471Tripartite motif-containing protein 60Add BLAST471

Proteomic databases

PaxDbiQ495X7
PeptideAtlasiQ495X7
PRIDEiQ495X7
ProteomicsDBi61977

PTM databases

iPTMnetiQ495X7
PhosphoSitePlusiQ495X7
SwissPalmiQ495X7

Expressioni

Gene expression databases

BgeeiENSG00000176979
CleanExiHS_TRIM60
ExpressionAtlasiQ495X7 baseline and differential

Organism-specific databases

HPAiHPA035809
HPA035810
HPA061496

Interactioni

Protein-protein interaction databases

IntActiQ495X7, 1 interactor
STRINGi9606.ENSP00000343765

Structurei

3D structure databases

ProteinModelPortaliQ495X7
SMRiQ495X7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 470B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili171 – 223Sequence analysisAdd BLAST53

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri92 – 133B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118893
HOGENOMiHOG000234133
HOVERGENiHBG001357
InParanoidiQ495X7
KOiK12029
OMAiCEKHNQF
OrthoDBiEOG091G05W2
PhylomeDBiQ495X7
TreeFamiTF338674

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd15828 SPRY_PRY_TRIM60, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR035786 SPRY/PRY_TRIM60
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q495X7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFVTALVNL QEESSCPICL EYLKDPVTIN CGHNFCRSCL SVSWKDLDDT
60 70 80 90 100
FPCPVCRFCF PYKSFRRNPQ LRNLTEIAKQ LQIRRSKRKR QKENAMCEKH
110 120 130 140 150
NQFLTLFCVK DLEILCTQCS FSTKHQKHYI CPIKKAASYH REILEGSLEP
160 170 180 190 200
LRNNIERVEK VIILQGSKSV ELKKKVEYKR EEINSEFEQI RLFLQNEQEM
210 220 230 240 250
ILRQIQDEEM NILAKLNENL VELSDYVSTL KHLLREVEGK SVQSNLELLT
260 270 280 290 300
QAKSMHHKYQ NLKCPELFSF RLTKYGFSLP PQYSGLDRII KPFQVDVILD
310 320 330 340 350
LNTAHPQLLV SEDRKAVRYE RKKRNICYDP RRFYVCPAVL GSQRFSSGRH
360 370 380 390 400
YWEVEVGNKP KWILGVCQDC LLRNWQDQPS VLGGFWAIGR YMKSGYVASG
410 420 430 440 450
PKTTQLLPVV KPSKIGIFLD YELGDLSFYN MNDRSILYTF NDCFTEAVWP
460 470
YFYTGTDSEP LKICSVSDSE R
Length:471
Mass (Da):55,114
Last modified:September 5, 2006 - v2
Checksum:i6E1E8986BBFC9238
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti445T → I in AAI00986 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093201 mRNA Translation: BAC04093.1
BC100983 mRNA Translation: AAI00984.1
BC100984 mRNA Translation: AAI00985.1
BC100985 mRNA Translation: AAI00986.1
BC100986 mRNA Translation: AAI00987.1
CCDSiCCDS3808.1
RefSeqiNP_001244954.1, NM_001258025.1
NP_689833.1, NM_152620.2
XP_011529985.1, XM_011531683.2
UniGeneiHs.368004

Genome annotation databases

EnsembliENST00000341062; ENSP00000343765; ENSG00000176979
ENST00000508504; ENSP00000426496; ENSG00000176979
ENST00000512596; ENSP00000421142; ENSG00000176979
GeneIDi166655
KEGGihsa:166655
UCSCiuc003iqy.2 human

Similar proteinsi

Entry informationi

Entry nameiTRI60_HUMAN
AccessioniPrimary (citable) accession number: Q495X7
Secondary accession number(s): Q8NA35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: June 20, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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