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Q495X7

- TRI60_HUMAN

UniProt

Q495X7 - TRI60_HUMAN

Protein

Tripartite motif-containing protein 60

Gene

TRIM60

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 5742RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri92 – 13342B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite motif-containing protein 60
    Alternative name(s):
    RING finger protein 129
    RING finger protein 33
    Gene namesi
    Name:TRIM60
    Synonyms:RNF129, RNF33
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:21162. TRIM60.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134909634.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471Tripartite motif-containing protein 60PRO_0000249189Add
    BLAST

    Proteomic databases

    PaxDbiQ495X7.
    PRIDEiQ495X7.

    PTM databases

    PhosphoSiteiQ495X7.

    Expressioni

    Gene expression databases

    BgeeiQ495X7.
    CleanExiHS_TRIM60.
    GenevestigatoriQ495X7.

    Organism-specific databases

    HPAiHPA035810.

    Structurei

    3D structure databases

    ProteinModelPortaliQ495X7.
    SMRiQ495X7. Positions 6-56, 295-464.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini277 – 470194B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili171 – 22353Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 5742RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri92 – 13342B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG253525.
    HOGENOMiHOG000234133.
    HOVERGENiHBG001357.
    InParanoidiQ495X7.
    KOiK12029.
    OMAiYHREILE.
    OrthoDBiEOG7MPRDJ.
    PhylomeDBiQ495X7.
    TreeFamiTF338674.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00336. BBOX. 1 hit.
    SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q495X7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFVTALVNL QEESSCPICL EYLKDPVTIN CGHNFCRSCL SVSWKDLDDT    50
    FPCPVCRFCF PYKSFRRNPQ LRNLTEIAKQ LQIRRSKRKR QKENAMCEKH 100
    NQFLTLFCVK DLEILCTQCS FSTKHQKHYI CPIKKAASYH REILEGSLEP 150
    LRNNIERVEK VIILQGSKSV ELKKKVEYKR EEINSEFEQI RLFLQNEQEM 200
    ILRQIQDEEM NILAKLNENL VELSDYVSTL KHLLREVEGK SVQSNLELLT 250
    QAKSMHHKYQ NLKCPELFSF RLTKYGFSLP PQYSGLDRII KPFQVDVILD 300
    LNTAHPQLLV SEDRKAVRYE RKKRNICYDP RRFYVCPAVL GSQRFSSGRH 350
    YWEVEVGNKP KWILGVCQDC LLRNWQDQPS VLGGFWAIGR YMKSGYVASG 400
    PKTTQLLPVV KPSKIGIFLD YELGDLSFYN MNDRSILYTF NDCFTEAVWP 450
    YFYTGTDSEP LKICSVSDSE R 471
    Length:471
    Mass (Da):55,114
    Last modified:September 5, 2006 - v2
    Checksum:i6E1E8986BBFC9238
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti445 – 4451T → I in AAI00986. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093201 mRNA. Translation: BAC04093.1.
    BC100983 mRNA. Translation: AAI00984.1.
    BC100984 mRNA. Translation: AAI00985.1.
    BC100985 mRNA. Translation: AAI00986.1.
    BC100986 mRNA. Translation: AAI00987.1.
    CCDSiCCDS3808.1.
    RefSeqiNP_001244954.1. NM_001258025.1.
    NP_689833.1. NM_152620.2.
    UniGeneiHs.368004.

    Genome annotation databases

    EnsembliENST00000341062; ENSP00000343765; ENSG00000176979.
    ENST00000508504; ENSP00000426496; ENSG00000176979.
    ENST00000512596; ENSP00000421142; ENSG00000176979.
    GeneIDi166655.
    KEGGihsa:166655.
    UCSCiuc003iqy.1. human.

    Polymorphism databases

    DMDMi114154820.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093201 mRNA. Translation: BAC04093.1 .
    BC100983 mRNA. Translation: AAI00984.1 .
    BC100984 mRNA. Translation: AAI00985.1 .
    BC100985 mRNA. Translation: AAI00986.1 .
    BC100986 mRNA. Translation: AAI00987.1 .
    CCDSi CCDS3808.1.
    RefSeqi NP_001244954.1. NM_001258025.1.
    NP_689833.1. NM_152620.2.
    UniGenei Hs.368004.

    3D structure databases

    ProteinModelPortali Q495X7.
    SMRi Q495X7. Positions 6-56, 295-464.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q495X7.

    Polymorphism databases

    DMDMi 114154820.

    Proteomic databases

    PaxDbi Q495X7.
    PRIDEi Q495X7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341062 ; ENSP00000343765 ; ENSG00000176979 .
    ENST00000508504 ; ENSP00000426496 ; ENSG00000176979 .
    ENST00000512596 ; ENSP00000421142 ; ENSG00000176979 .
    GeneIDi 166655.
    KEGGi hsa:166655.
    UCSCi uc003iqy.1. human.

    Organism-specific databases

    CTDi 166655.
    GeneCardsi GC04P165953.
    HGNCi HGNC:21162. TRIM60.
    HPAi HPA035810.
    neXtProti NX_Q495X7.
    PharmGKBi PA134909634.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253525.
    HOGENOMi HOG000234133.
    HOVERGENi HBG001357.
    InParanoidi Q495X7.
    KOi K12029.
    OMAi YHREILE.
    OrthoDBi EOG7MPRDJ.
    PhylomeDBi Q495X7.
    TreeFami TF338674.

    Miscellaneous databases

    GenomeRNAii 166655.
    NextBioi 88609.
    PROi Q495X7.

    Gene expression databases

    Bgeei Q495X7.
    CleanExi HS_TRIM60.
    Genevestigatori Q495X7.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00336. BBOX. 1 hit.
    SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiTRI60_HUMAN
    AccessioniPrimary (citable) accession number: Q495X7
    Secondary accession number(s): Q8NA35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3