Q495X7 (TRI60_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tripartite motif-containing protein 60

Alternative name(s):
RING finger protein 129
RING finger protein 33

Gene names

Name:	TRIM60
Synonyms:	RNF129, RNF33

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 471	471	Tripartite motif-containing protein 60		PRO_0000249189
Regions
	Domain	277 – 470	194	B30.2/SPRY
	Zinc finger	16 – 57	42	RING-type
	Zinc finger	92 – 133	42	B box-type
	Coiled coil	171 – 223	53	Potential
Experimental info
	Sequence conflict	445	1	T → I in AAI00986. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q495X7 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: 6E1E8986BBFC9238	FASTA	471	55,114
	10 20 30 40 50 60 MEFVTALVNL QEESSCPICL EYLKDPVTIN CGHNFCRSCL SVSWKDLDDT FPCPVCRFCF 70 80 90 100 110 120 PYKSFRRNPQ LRNLTEIAKQ LQIRRSKRKR QKENAMCEKH NQFLTLFCVK DLEILCTQCS 130 140 150 160 170 180 FSTKHQKHYI CPIKKAASYH REILEGSLEP LRNNIERVEK VIILQGSKSV ELKKKVEYKR 190 200 210 220 230 240 EEINSEFEQI RLFLQNEQEM ILRQIQDEEM NILAKLNENL VELSDYVSTL KHLLREVEGK 250 260 270 280 290 300 SVQSNLELLT QAKSMHHKYQ NLKCPELFSF RLTKYGFSLP PQYSGLDRII KPFQVDVILD 310 320 330 340 350 360 LNTAHPQLLV SEDRKAVRYE RKKRNICYDP RRFYVCPAVL GSQRFSSGRH YWEVEVGNKP 370 380 390 400 410 420 KWILGVCQDC LLRNWQDQPS VLGGFWAIGR YMKSGYVASG PKTTQLLPVV KPSKIGIFLD 430 440 450 460 470 YELGDLSFYN MNDRSILYTF NDCFTEAVWP YFYTGTDSEP LKICSVSDSE R

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK093201 mRNA. Translation: BAC04093.1. BC100983 mRNA. Translation: AAI00984.1. BC100984 mRNA. Translation: AAI00985.1. BC100985 mRNA. Translation: AAI00986.1. BC100986 mRNA. Translation: AAI00987.1.
IPI	IPI00167899.
RefSeq	NP_001244954.1. NM_001258025.1. NP_689833.1. NM_152620.2.
UniGene	Hs.368004.
3D structure databases
ProteinModelPortal	Q495X7.
ModBase	Search...
PTM databases
PhosphoSite	Q495X7.
Polymorphism databases
DMDM	114154820.
Proteomic databases
PaxDb	Q495X7.
PRIDE	Q495X7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341062; ENSP00000343765; ENSG00000176979. ENST00000508504; ENSP00000426496; ENSG00000176979. ENST00000512596; ENSP00000421142; ENSG00000176979.
GeneID	166655.
KEGG	hsa:166655.
UCSC	uc003iqy.1. human.
Organism-specific databases
CTD	166655.
GeneCards	GC04P165953.
HGNC	HGNC:21162. TRIM60.
HPA	HPA035810.
neXtProt	NX_Q495X7.
PharmGKB	PA134909634.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG253525.
HOGENOM	HOG000234133.
HOVERGEN	HBG001357.
InParanoid	Q495X7.
KO	K12029.
OMA	VSWKDLD.
OrthoDB	EOG4NP73C.
PhylomeDB	Q495X7.
Gene expression databases
ArrayExpress	Q495X7.
Bgee	Q495X7.
CleanEx	HS_TRIM60.
Genevestigator	Q495X7.
Family and domain databases
Gene3D	3.30.40.10. 1 hit. 4.10.45.10. 1 hit.
InterPro	IPR001870. B30.2/SPRY. IPR003879. Butyrophylin. IPR008985. ConA-like_lec_gl_sf. IPR006574. PRY. IPR003877. SPRY_rcpt. IPR000315. Znf_B-box. IPR018957. Znf_C3HC4_RING-type. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF00622. SPRY. 1 hit. PF00643. zf-B_box. 1 hit. PF00097. zf-C3HC4. 1 hit. [Graphical view]
PRINTS	PR01407. BUTYPHLNCDUF.
SMART	SM00336. BBOX. 1 hit. SM00589. PRY. 1 hit. SM00184. RING. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50188. B302_SPRY. 1 hit. PS50119. ZF_BBOX. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	166655.
NextBio	88609.

Entry information

Entry name

TRI60_HUMAN

Accession

Primary (citable) accession number: Q495X7
Secondary accession number(s): Q8NA35

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	May 29, 2013
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.