Q495P6 (Q495P6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Toll-like receptor 8 EMBL AAI01076.1

Gene names

Name:

TLR8 EMBL AAI01076.1

Organism

Homo sapiens (Human) EMBL AAI01076.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1041 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 TIR domain. SAAS SAAS000157

Ontologies

Keywords
Cellular component	Membrane
Domain	Leucine-rich repeat SAAS SAAS000157 Repeat SAAS SAAS000157 Transmembrane Transmembrane helix SAAS SAAS000483
Molecular function	Receptor EMBL AAI01076.1
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q495P6 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 62981B73DAA44802	FASTA	1,041	119,814
	10 20 30 40 50 60 MENMFLQSSM LTCIFLLISG SCELCAEENF SRSYPCDEKK QNDSVIAECS NRRLQEVPQT 70 80 90 100 110 120 VGKYVTELDL SDNFITHITN ESFQGLQNLT KINLNHNPNV QHQNGNPGIQ SNGLNITDGA 130 140 150 160 170 180 FLNLKNLREL LLEDNQLPQI PSGLPESLTE LSLIQNNIYN ITKEGISRLI NLKNLYLAWN 190 200 210 220 230 240 CYFNKVCEKT NIEDGVFETL TNLELLSLSF NSLSHVPPKL PSSLRKLFLS NTQIKYISEE 250 260 270 280 290 300 DFKGLINLTL LDLSGNCPRC FNAPFPCVPC DGGASINIDR FAFQNLTQLR YLNLSSTSLR 310 320 330 340 350 360 KINAAWFKNM PHLKVLDLEF NYLVGEIASG AFLTMLPRLE ILDLSFNYIK GSYPQHINIS 370 380 390 400 410 420 RNFSKLLSLR ALHLRGYVFQ ELREDDFQPL MQLPNLSTIN LGINFIKQID FKLFQNFSNL 430 440 450 460 470 480 EIIYLSENRI SPLVKDTRQS YANSSSFQRH IRKRRSTDFE FDPHSNFYHF TRPLIKPQCA 490 500 510 520 530 540 AYGKALDLSL NSIFFIGPNQ FENLPDIACL NLSANSNAQV LSGTEFSAIP HVKYLDLTNN 550 560 570 580 590 600 RLDFDNASAL TELSDLEVLD LSYNSHYFRI AGVTHHLEFI QNFTNLKVLN LSHNNIYTLT 610 620 630 640 650 660 DKYNLESKSL VELVFSGNRL DILWNDDDNR YISIFKGLKN LTRLDLSLNR LKHIPNEAFL 670 680 690 700 710 720 NLPASLTELH INDNMLKFFN WTLLQQFPRL ELLDLRGNKL LFLTDSLSDF TSSLRTLLLS 730 740 750 760 770 780 HNRISHLPSG FLSEVSSLKH LDLSSNLLKT INKSALETKT TTKLSMLELH GNPFECTCDI 790 800 810 820 830 840 GDFRRWMDEH LNVKIPRLVD VICASPGDQR GKSIVSLELT TCVSDVTAVI LFFFTFFITT 850 860 870 880 890 900 MVMLAALAHH LFYWDVWFIY NVCLAKVKGY RSLSTSQTFY DAYVSYDTKD ASVTDWVINE 910 920 930 940 950 960 LRYHLEESRD KNVLLCLEER DWDPGLAIID NLMQSINQSK KTVFVLTKKY AKSWNFKTAF 970 980 990 1000 1010 1020 YLALQRLMDE NMDVIIFILL EPVLQHSQYL RLRQRICKSS ILQWPDNPKA EGLFWQTLRN 1030 1040 VVLTENDSRY NNMYVDSIKQ Y

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: PCR rescued clones EMBL AAI01076.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC101075 mRNA. Translation: AAI01076.1.
IPI	IPI00335051.
UniGene	Hs.660543.
3D structure databases
ProteinModelPortal	Q495P6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q495P6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG018601.
Gene expression databases
ArrayExpress	Q495P6.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000157. TIR_dom. [Graphical view]
Pfam	PF00560. LRR_1. 5 hits. PF01582. TIR. 1 hit. [Graphical view]
SMART	SM00369. LRR_TYP. 3 hits. SM00082. LRRCT. 1 hit. [Graphical view]
SUPFAM	SSF52200. TIR. 1 hit.
PROSITE	PS51450. LRR. 20 hits. PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q495P6_HUMAN

Accession

Primary (citable) accession number: Q495P6

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	December 14, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.