Unreviewed, UniProtKB/TrEMBL Q495P6 (Q495P6_HUMAN)

Names and origin

Protein names

Submitted name:
    Toll-like receptor 8 EMBL AAI01076.1

Gene names

Name:

TLR8 EMBL AAI01076.1

Organism

Homo sapiens (Human) EMBL AAI01076.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1041 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 TIR domain. Spearmint SPM004075

Ontologies

Keywords
Domain	Leucine-rich repeat Spearmint SPM003591 Repeat Spearmint SPM003591
Molecular function	Receptor
Gene Ontology (GO)
Biological process	innate immune response Inferred from electronic annotation. Source: InterPro signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intrinsic to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro transmembrane receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q495P6-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 62981B73DAA44802	FASTA	1,041	119,814
	10 20 30 40 50 60 MENMFLQSSM LTCIFLLISG SCELCAEENF SRSYPCDEKK QNDSVIAECS NRRLQEVPQT 70 80 90 100 110 120 VGKYVTELDL SDNFITHITN ESFQGLQNLT KINLNHNPNV QHQNGNPGIQ SNGLNITDGA 130 140 150 160 170 180 FLNLKNLREL LLEDNQLPQI PSGLPESLTE LSLIQNNIYN ITKEGISRLI NLKNLYLAWN 190 200 210 220 230 240 CYFNKVCEKT NIEDGVFETL TNLELLSLSF NSLSHVPPKL PSSLRKLFLS NTQIKYISEE 250 260 270 280 290 300 DFKGLINLTL LDLSGNCPRC FNAPFPCVPC DGGASINIDR FAFQNLTQLR YLNLSSTSLR 310 320 330 340 350 360 KINAAWFKNM PHLKVLDLEF NYLVGEIASG AFLTMLPRLE ILDLSFNYIK GSYPQHINIS 370 380 390 400 410 420 RNFSKLLSLR ALHLRGYVFQ ELREDDFQPL MQLPNLSTIN LGINFIKQID FKLFQNFSNL 430 440 450 460 470 480 EIIYLSENRI SPLVKDTRQS YANSSSFQRH IRKRRSTDFE FDPHSNFYHF TRPLIKPQCA 490 500 510 520 530 540 AYGKALDLSL NSIFFIGPNQ FENLPDIACL NLSANSNAQV LSGTEFSAIP HVKYLDLTNN 550 560 570 580 590 600 RLDFDNASAL TELSDLEVLD LSYNSHYFRI AGVTHHLEFI QNFTNLKVLN LSHNNIYTLT 610 620 630 640 650 660 DKYNLESKSL VELVFSGNRL DILWNDDDNR YISIFKGLKN LTRLDLSLNR LKHIPNEAFL 670 680 690 700 710 720 NLPASLTELH INDNMLKFFN WTLLQQFPRL ELLDLRGNKL LFLTDSLSDF TSSLRTLLLS 730 740 750 760 770 780 HNRISHLPSG FLSEVSSLKH LDLSSNLLKT INKSALETKT TTKLSMLELH GNPFECTCDI 790 800 810 820 830 840 GDFRRWMDEH LNVKIPRLVD VICASPGDQR GKSIVSLELT TCVSDVTAVI LFFFTFFITT 850 860 870 880 890 900 MVMLAALAHH LFYWDVWFIY NVCLAKVKGY RSLSTSQTFY DAYVSYDTKD ASVTDWVINE 910 920 930 940 950 960 LRYHLEESRD KNVLLCLEER DWDPGLAIID NLMQSINQSK KTVFVLTKKY AKSWNFKTAF 970 980 990 1000 1010 1020 YLALQRLMDE NMDVIIFILL EPVLQHSQYL RLRQRICKSS ILQWPDNPKA EGLFWQTLRN 1030 1040 VVLTENDSRY NNMYVDSIKQ Y

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: PCR rescued clones EMBL AAI01076.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC101075 mRNA. Translation: AAI01076.1.
UniGene	Hs.660543
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000101916. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:15632. TLR8.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q495P6.
Gene expression databases
ArrayExpress	Q495P6.
Family and domain databases
InterPro	IPR004075. IL1_rcpt_1. IPR001611. Leu-rich_rpt. IPR015764. Leu-rich_rpt_Toll-like_rcpt8. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000483. LRR_C. IPR000157. Toll-Interleukin_rcpt. [Graphical view]
PANTHER	PTHR23154:SF59. L_r_r_TLR8. 1 hit.
Pfam	PF00560. LRR_1. 15 hits. PF01582. TIR. 1 hit. [Graphical view]
PRINTS	PR01537. INTRLKN1R1F. PR00019. LEURICHRPT.
SMART	SM00369. LRR_TYP. 3 hits. SM00082. LRRCT. 1 hit. [Graphical view]
PROSITE	PS50104. TIR. 1 hit. [Graphical view]

Entry information

Entry name

Q495P6_HUMAN

Accession

Primary (citable) accession number: Q495P6

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	November 25, 2008
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)