##gff-version 3 Q495M3 UniProtKB Chain 1 483 . . . ID=PRO_0000324819;Note=Proton-coupled amino acid transporter 2 Q495M3 UniProtKB Topological domain 1 58 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Transmembrane 59 79 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Topological domain 80 81 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Transmembrane 82 102 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Topological domain 103 148 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Transmembrane 149 169 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Topological domain 170 197 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Transmembrane 198 218 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Topological domain 219 222 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Transmembrane 223 243 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Topological domain 244 264 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Transmembrane 265 285 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Topological domain 286 296 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Transmembrane 297 317 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Topological domain 318 349 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Transmembrane 350 370 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Topological domain 371 379 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Transmembrane 380 400 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Topological domain 401 404 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Transmembrane 405 425 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Topological domain 426 437 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Transmembrane 438 458 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Topological domain 459 483 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q495M3 UniProtKB Region 26 46 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q495M3 UniProtKB Alternative sequence 1 276 . . . ID=VSP_032371;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q495M3 UniProtKB Alternative sequence 1 198 . . . ID=VSP_032372;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q495M3 UniProtKB Alternative sequence 277 281 . . . ID=VSP_032373;Note=In isoform 3. ESIGV->MNDTA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q495M3 UniProtKB Natural variant 87 87 . . . ID=VAR_064795;Note=In HG and IG%3B no effect on localization to the plasma membrane%3B decreased amino acid:proton symporter activity%3B no effect on protein reaction kinetics%3B decreased affinity for proline%3B 3-fold increase of Km value for proline%3B decreased affinity for glycine%3B 5-fold increase of Km for glycine. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19033659;Dbxref=dbSNP:rs77010315,PMID:19033659 Q495M3 UniProtKB Natural variant 445 445 . . . ID=VAR_039887;Note=A->V;Dbxref=dbSNP:rs10042608 Q495M3 UniProtKB Sequence conflict 156 156 . . . Note=I->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q495M3 UniProtKB Sequence conflict 408 408 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q495M3 UniProtKB Sequence conflict 410 410 . . . Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q495M3 UniProtKB Sequence conflict 429 429 . . . Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305