Q494X3 (ZN404_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 404

Gene names

Name:

ZNF404

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	552 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 15 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 552	552	Zinc finger protein 404		PRO_0000305136
Regions
	Domain	6 – 78	73	KRAB
	Zinc finger	131 – 153	23	C2H2-type 1; degenerate
	Zinc finger	159 – 181	23	C2H2-type 2
	Zinc finger	187 – 209	23	C2H2-type 3
	Zinc finger	215 – 237	23	C2H2-type 4
	Zinc finger	243 – 265	23	C2H2-type 5
	Zinc finger	271 – 293	23	C2H2-type 6
	Zinc finger	299 – 321	23	C2H2-type 7
	Zinc finger	327 – 349	23	C2H2-type 8
	Zinc finger	355 – 377	23	C2H2-type 9
	Zinc finger	383 – 405	23	C2H2-type 10
	Zinc finger	411 – 433	23	C2H2-type 11
	Zinc finger	439 – 461	23	C2H2-type 12
	Zinc finger	467 – 489	23	C2H2-type 13
	Zinc finger	495 – 517	23	C2H2-type 14
	Zinc finger	523 – 545	23	C2H2-type 15
Natural variations
	Natural variant	233	1	H → Y. Ref.1 Corresponds to variant rs12977303 [ dbSNP | Ensembl ].		VAR_057419

Sequences

	Sequence		Length	Mass (Da)
	Q494X3 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 3694878CC6350D7E	FASTA	552	65,455
	10 20 30 40 50 60 MARVPLTFSD VAIDFSQEEW EYLNSDQRDL YRDVMLENYT NLVSLDFNFT TESNKLSSEK 70 80 90 100 110 120 RNYEVNAYHQ ETWKRNKTFN LMRFIFRTDP QYTIEFGRQQ RPKVGCFSQM IFKKHKSLPL 130 140 150 160 170 180 HKRNNTREKS YECKEYKKGF RKYLHLTEHL RDHTGVIPYE CNECGKAFVV FQHFIRHRKI 190 200 210 220 230 240 HTDLKPYECN GCEKAFRFYS QLIQHQIIHT GMKPYECKQC GKAFRRHSHL TEHQKIHVGL 250 260 270 280 290 300 KPFECKECGE TFRLYRHMCL HQKIHHGVKP YKCKECGKAF GHRSSLYQHK KIHSGEKPYK 310 320 330 340 350 360 CEQCEKAFVR SYLLVEHQRS HTGEKPHECM ECGKAFSKGS SLLKHKRIHS SEKLYDCKDC 370 380 390 400 410 420 GKAFCRGSQL TQHQRIHTGE KPHECKECGK TFKLHSYLIQ HQIIHTDLKP YECKQCGKAF 430 440 450 460 470 480 SRVGDLKTHQ SIHAGEKPYE CKECGKTFRL NSQLIYHQTI HTGLKPYVCK ECKKAFRSIS 490 500 510 520 530 540 GLSQHKRIHT GEKPYECKEC DKAFNRSDRL TQHETIHTGV KPQKCKECGK AFSHCYQLSQ 550 HQRFHHGERL LM

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-233.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC101332 mRNA. Translation: AAI01333.1. BC101333 mRNA. Translation: AAI01334.1.
IPI	IPI00247202.
RefSeq	NP_001028891.2. NM_001033719.2.
UniGene	Hs.76561.
3D structure databases
ProteinModelPortal	Q494X3.
ModBase	Search...
PTM databases
PhosphoSite	Q494X3.
Polymorphism databases
DMDM	121943242.
Proteomic databases
PaxDb	Q494X3.
PRIDE	Q494X3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000324394; ENSP00000319479; ENSG00000176222.
GeneID	342908.
KEGG	hsa:342908.
UCSC	uc002oxs.4. human.
Organism-specific databases
CTD	342908.
GeneCards	GC19M044376.
HGNC	HGNC:19417. ZNF404.
HPA	HPA032014.
neXtProt	NX_Q494X3.
PharmGKB	PA134880927.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q494X3.
KO	K09228.
OrthoDB	EOG4M0F19.
Gene expression databases
ArrayExpress	Q494X3.
Bgee	Q494X3.
CleanEx	HS_ZNF404.
Genevestigator	Q494X3.
Family and domain databases
Gene3D	3.30.160.60. 15 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 15 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 14 hits. PS50157. ZINC_FINGER_C2H2_2. 15 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	342908.
NextBio	98388.

Entry information

Entry name

ZN404_HUMAN

Accession

Primary (citable) accession number: Q494X3
Secondary accession number(s): A4FU30

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	September 13, 2005
Last modified:	May 29, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.