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Protein

Zinc finger protein 404

Gene

ZNF404

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 153C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 404
Gene namesi
Name:ZNF404
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000176222.8
HGNCiHGNC:19417 ZNF404
neXtProtiNX_Q494X3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176222
PharmGKBiPA134880927

Polymorphism and mutation databases

BioMutaiZNF404
DMDMi121943242

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051361 – 552Zinc finger protein 404Add BLAST552

Proteomic databases

PaxDbiQ494X3
PeptideAtlasiQ494X3
PRIDEiQ494X3
ProteomicsDBi61947

PTM databases

iPTMnetiQ494X3
PhosphoSitePlusiQ494X3

Expressioni

Gene expression databases

BgeeiENSG00000176222
CleanExiHS_ZNF404
ExpressionAtlasiQ494X3 baseline and differential
GenevisibleiQ494X3 HS

Organism-specific databases

HPAiHPA032014
HPA063607

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2P502223EBI-10241626,EBI-748397

Protein-protein interaction databases

BioGridi131207, 2 interactors
IntActiQ494X3, 1 interactor
STRINGi9606.ENSP00000466051

Structurei

3D structure databases

ProteinModelPortaliQ494X3
SMRiQ494X3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 78KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 153C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ494X3
KOiK09228
OMAiHHGVKPY
OrthoDBiEOG091G02KC

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequencei

Sequence statusi: Complete.

Q494X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARVPLTFSD VAIDFSQEEW EYLNSDQRDL YRDVMLENYT NLVSLDFNFT
60 70 80 90 100
TESNKLSSEK RNYEVNAYHQ ETWKRNKTFN LMRFIFRTDP QYTIEFGRQQ
110 120 130 140 150
RPKVGCFSQM IFKKHKSLPL HKRNNTREKS YECKEYKKGF RKYLHLTEHL
160 170 180 190 200
RDHTGVIPYE CNECGKAFVV FQHFIRHRKI HTDLKPYECN GCEKAFRFYS
210 220 230 240 250
QLIQHQIIHT GMKPYECKQC GKAFRRHSHL TEHQKIHVGL KPFECKECGE
260 270 280 290 300
TFRLYRHMCL HQKIHHGVKP YKCKECGKAF GHRSSLYQHK KIHSGEKPYK
310 320 330 340 350
CEQCEKAFVR SYLLVEHQRS HTGEKPHECM ECGKAFGKGS SLLKHKRIHS
360 370 380 390 400
SEKLYDCKDC GKAFCRGSQL TQHQRIHTGE KPHECKECGK TFKLHSYLIQ
410 420 430 440 450
HQIIHTDLKP YECKQCGKAF SRVGDLKTHQ SIHAGEKPYE CKECGKTFRL
460 470 480 490 500
NSQLIYHQTI HTGLKPYVCK ECKKAFRSIS GLSQHKRIHT GEKPYECKEC
510 520 530 540 550
DKAFNRSDRL TQHETIHTGV KPQKCKECGK AFSHCYQLSQ HQRFHHGERL

LM
Length:552
Mass (Da):65,425
Last modified:March 19, 2014 - v2
Checksum:i9E89530D8E218C30
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057419233H → Y1 PublicationCorresponds to variant dbSNP:rs12977303Ensembl.1
Natural variantiVAR_070605337G → S1 PublicationCorresponds to variant dbSNP:rs239942Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006213 Genomic DNA No translation available.
AC011508 Genomic DNA No translation available.
BC101332 mRNA Translation: AAI01333.1
BC101333 mRNA Translation: AAI01334.1
CCDSiCCDS59394.1
RefSeqiNP_001028891.2, NM_001033719.2
UniGeneiHs.76561

Genome annotation databases

EnsembliENST00000587539; ENSP00000466051; ENSG00000176222
GeneIDi342908
KEGGihsa:342908
UCSCiuc002oxs.7 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN404_HUMAN
AccessioniPrimary (citable) accession number: Q494X3
Secondary accession number(s): A4FU30, K7ELF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 19, 2014
Last modified: June 20, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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