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Protein

Zinc finger protein 404

Gene

ZNF404

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri131 – 15323C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri159 – 18123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri187 – 20923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54523C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 404
Gene namesi
Name:ZNF404
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:19417. ZNF404.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880927.

Polymorphism and mutation databases

BioMutaiZNF404.
DMDMi121943242.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Zinc finger protein 404PRO_0000305136Add
BLAST

Proteomic databases

PaxDbiQ494X3.
PeptideAtlasiQ494X3.
PRIDEiQ494X3.

PTM databases

iPTMnetiQ494X3.
PhosphoSiteiQ494X3.

Expressioni

Gene expression databases

BgeeiENSG00000176222.
CleanExiHS_ZNF404.
ExpressionAtlasiQ494X3. baseline and differential.
GenevisibleiQ494X3. HS.

Organism-specific databases

HPAiHPA032014.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2A4D1273EBI-10241626,EBI-10172134

Protein-protein interaction databases

BioGridi131207. 1 interaction.
IntActiQ494X3. 1 interaction.
STRINGi9606.ENSP00000466051.

Structurei

3D structure databases

ProteinModelPortaliQ494X3.
SMRiQ494X3. Positions 6-49, 112-545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7873KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri131 – 15323C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri159 – 18123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri187 – 20923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54523C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ494X3.
KOiK09228.
OMAiHHGVKPY.
OrthoDBiEOG091G02KC.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q494X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARVPLTFSD VAIDFSQEEW EYLNSDQRDL YRDVMLENYT NLVSLDFNFT
60 70 80 90 100
TESNKLSSEK RNYEVNAYHQ ETWKRNKTFN LMRFIFRTDP QYTIEFGRQQ
110 120 130 140 150
RPKVGCFSQM IFKKHKSLPL HKRNNTREKS YECKEYKKGF RKYLHLTEHL
160 170 180 190 200
RDHTGVIPYE CNECGKAFVV FQHFIRHRKI HTDLKPYECN GCEKAFRFYS
210 220 230 240 250
QLIQHQIIHT GMKPYECKQC GKAFRRHSHL TEHQKIHVGL KPFECKECGE
260 270 280 290 300
TFRLYRHMCL HQKIHHGVKP YKCKECGKAF GHRSSLYQHK KIHSGEKPYK
310 320 330 340 350
CEQCEKAFVR SYLLVEHQRS HTGEKPHECM ECGKAFGKGS SLLKHKRIHS
360 370 380 390 400
SEKLYDCKDC GKAFCRGSQL TQHQRIHTGE KPHECKECGK TFKLHSYLIQ
410 420 430 440 450
HQIIHTDLKP YECKQCGKAF SRVGDLKTHQ SIHAGEKPYE CKECGKTFRL
460 470 480 490 500
NSQLIYHQTI HTGLKPYVCK ECKKAFRSIS GLSQHKRIHT GEKPYECKEC
510 520 530 540 550
DKAFNRSDRL TQHETIHTGV KPQKCKECGK AFSHCYQLSQ HQRFHHGERL

LM
Length:552
Mass (Da):65,425
Last modified:March 19, 2014 - v2
Checksum:i9E89530D8E218C30
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti233 – 2331H → Y.1 Publication
Corresponds to variant rs12977303 [ dbSNP | Ensembl ].
VAR_057419
Natural varianti337 – 3371G → S.1 Publication
Corresponds to variant rs239942 [ dbSNP | Ensembl ].
VAR_070605

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006213 Genomic DNA. No translation available.
AC011508 Genomic DNA. No translation available.
BC101332 mRNA. Translation: AAI01333.1.
BC101333 mRNA. Translation: AAI01334.1.
CCDSiCCDS59394.1.
RefSeqiNP_001028891.2. NM_001033719.2.
UniGeneiHs.76561.

Genome annotation databases

EnsembliENST00000587539; ENSP00000466051; ENSG00000176222.
GeneIDi342908.
KEGGihsa:342908.
UCSCiuc002oxs.7. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006213 Genomic DNA. No translation available.
AC011508 Genomic DNA. No translation available.
BC101332 mRNA. Translation: AAI01333.1.
BC101333 mRNA. Translation: AAI01334.1.
CCDSiCCDS59394.1.
RefSeqiNP_001028891.2. NM_001033719.2.
UniGeneiHs.76561.

3D structure databases

ProteinModelPortaliQ494X3.
SMRiQ494X3. Positions 6-49, 112-545.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131207. 1 interaction.
IntActiQ494X3. 1 interaction.
STRINGi9606.ENSP00000466051.

PTM databases

iPTMnetiQ494X3.
PhosphoSiteiQ494X3.

Polymorphism and mutation databases

BioMutaiZNF404.
DMDMi121943242.

Proteomic databases

PaxDbiQ494X3.
PeptideAtlasiQ494X3.
PRIDEiQ494X3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000587539; ENSP00000466051; ENSG00000176222.
GeneIDi342908.
KEGGihsa:342908.
UCSCiuc002oxs.7. human.

Organism-specific databases

CTDi342908.
GeneCardsiZNF404.
HGNCiHGNC:19417. ZNF404.
HPAiHPA032014.
neXtProtiNX_Q494X3.
PharmGKBiPA134880927.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ494X3.
KOiK09228.
OMAiHHGVKPY.
OrthoDBiEOG091G02KC.

Miscellaneous databases

GenomeRNAii342908.
PROiQ494X3.

Gene expression databases

BgeeiENSG00000176222.
CleanExiHS_ZNF404.
ExpressionAtlasiQ494X3. baseline and differential.
GenevisibleiQ494X3. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN404_HUMAN
AccessioniPrimary (citable) accession number: Q494X3
Secondary accession number(s): A4FU30, K7ELF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 19, 2014
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.