ID   CRFM7_HUMAN             Reviewed;         412 AA.
AC   Q494W8; A8KAB9;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 142.
DE   RecName: Full=CHRNA7-FAM7A fusion protein;
DE   AltName: Full=CHRNA7-DR1;
DE   AltName: Full=D-10;
GN   Name=CHRFAM7A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-62, AND TISSUE SPECIFICITY.
RC   TISSUE=Hippocampus;
RX   PubMed=9782083; DOI=10.1006/geno.1998.5363;
RA   Gault J., Robinson M., Berger R., Drebing C., Logel J., Hopkins J.,
RA   Moore T., Jacobs S., Meriwether J., Choi M.J., Kim E.J., Walton K.,
RA   Buiting K., Davis A., Breese C., Freedman R., Leonard S.;
RT   "Genomic organization and partial duplication of the human alpha7 neuronal
RT   nicotinic acetylcholine receptor gene (CHRNA7).";
RL   Genomics 52:173-185(1998).
CC   -!- INTERACTION:
CC       Q494W8; P36544: CHRNA7; NbExp=3; IntAct=EBI-20798208, EBI-79333;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in hippocampus.
CC       {ECO:0000269|PubMed:9782083}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       {ECO:0000305}.
CC   -!- CAUTION: This protein is encoded by a hybrid gene consisting of a
CC       duplication of exons 5 through 10 of the CHRNA7 gene fused 3-prime to a
CC       copy of the FAM7A gene (exons A through E). The CHRFAM7A gene is in the
CC       opposite orientation to the CHRNA7 gene. It seems not to be represented
CC       on every human chromosome 15 and it is not clear whether the transcript
CC       is actually translated. {ECO:0000305}.
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DR   EMBL; AK292984; BAF85673.1; -; mRNA.
DR   EMBL; BC101346; AAI01347.1; -; mRNA.
DR   EMBL; BC101347; AAI01348.1; -; mRNA.
DR   EMBL; BC101348; AAI01349.1; -; mRNA.
DR   EMBL; AC010799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC019322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF029838; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS32184.1; -.
DR   RefSeq; NP_647536.1; NM_139320.1.
DR   RefSeq; XP_011520455.1; XM_011522153.1.
DR   AlphaFoldDB; Q494W8; -.
DR   SMR; Q494W8; -.
DR   BioGRID; 124609; 2.
DR   IntAct; Q494W8; 2.
DR   MINT; Q494W8; -.
DR   STRING; 9606.ENSP00000299847; -.
DR   DrugBank; DB07494; (3-EXO)-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8,8-DIMETHYL-8-AZONIABICYCLO[3.2.1]OCTANE.
DR   DrugBank; DB07720; Epibatidine.
DR   DrugBank; DB11421; Imidacloprid.
DR   DrugBank; DB08620; Thiacloprid.
DR   BioMuta; CHRFAM7A; -.
DR   DMDM; 91208254; -.
DR   MassIVE; Q494W8; -.
DR   PaxDb; 9606-ENSP00000299847; -.
DR   PeptideAtlas; Q494W8; -.
DR   Antibodypedia; 9365; 175 antibodies from 25 providers.
DR   DNASU; 89832; -.
DR   Ensembl; ENST00000299847.7; ENSP00000299847.3; ENSG00000166664.15.
DR   GeneID; 89832; -.
DR   KEGG; hsa:89832; -.
DR   MANE-Select; ENST00000299847.7; ENSP00000299847.3; NM_139320.2; NP_647536.1.
DR   UCSC; uc001zdt.2; human.
DR   AGR; HGNC:15781; -.
DR   CTD; 89832; -.
DR   DisGeNET; 89832; -.
DR   GeneCards; CHRFAM7A; -.
DR   HGNC; HGNC:15781; CHRFAM7A.
DR   HPA; ENSG00000166664; Tissue enhanced (bone marrow, parathyroid gland).
DR   MIM; 609756; gene.
DR   neXtProt; NX_Q494W8; -.
DR   OpenTargets; ENSG00000166664; -.
DR   PharmGKB; PA26483; -.
DR   VEuPathDB; HostDB:ENSG00000166664; -.
DR   eggNOG; KOG3646; Eukaryota.
DR   GeneTree; ENSGT00940000154617; -.
DR   HOGENOM; CLU_018074_0_3_1; -.
DR   InParanoid; Q494W8; -.
DR   OMA; CCPQNSD; -.
DR   OrthoDB; 5489962at2759; -.
DR   PhylomeDB; Q494W8; -.
DR   TreeFam; TF315605; -.
DR   PathwayCommons; Q494W8; -.
DR   SignaLink; Q494W8; -.
DR   BioGRID-ORCS; 89832; 23 hits in 1038 CRISPR screens.
DR   ChiTaRS; CHRFAM7A; human.
DR   GenomeRNAi; 89832; -.
DR   Pharos; Q494W8; Tbio.
DR   PRO; PR:Q494W8; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q494W8; Protein.
DR   Bgee; ENSG00000166664; Expressed in primordial germ cell in gonad and 100 other cell types or tissues.
DR   ExpressionAtlas; Q494W8; baseline and differential.
DR   GO; GO:0005892; C:acetylcholine-gated channel complex; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0098794; C:postsynapse; IEA:GOC.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0042166; F:acetylcholine binding; IBA:GO_Central.
DR   GO; GO:0022848; F:acetylcholine-gated monoatomic cation-selective channel activity; IBA:GO_Central.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007271; P:synaptic transmission, cholinergic; IBA:GO_Central.
DR   CDD; cd19051; LGIC_TM_cation; 1.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   NCBIfam; TIGR00860; LIC; 1.
DR   PANTHER; PTHR18945:SF907; CHRNA7-FAM7A FUSION PROTEIN-RELATED; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
DR   Genevisible; Q494W8; HS.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..412
FT                   /note="CHRNA7-FAM7A fusion protein"
FT                   /id="PRO_0000232101"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   412 AA;  46218 MW;  17D1A33E8540BF44 CRC64;
     MQKYCIYQHF QFQLLIQHLW IAANCDIADE RFDATFHTNV LVNSSGHCQY LPPGIFKSSC
     YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL QMQEADISGY IPNGEWDLVG IPGKRSERFY
     ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP CVLISALALL VFLLPADSGE KISLGITVLL
     SLTVFMLLVA EIMPATSDSV PLIAQYFAST MIIVGLSVVV TVIVLQYHHH DPDGGKMPKW
     TRVILLNWCA WFLRMKRPGE DKVRPACQHK QRRCSLASVE MSAVAPPPAS NGNLLYIGFR
     GLDGVHCVPT PDSGVVCGRM ACSPTHDEHL LHGGQPPEGD PDLAKILEEV RYIANRFRCQ
     DESEAVCSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD FA
//