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Protein

Cilia- and flagella-associated protein 100

Gene

CFAP100

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 100Curated
Alternative name(s):
Coiled-coil domain-containing protein 37Curated
Gene namesi
Name:CFAP100Imported
Synonyms:CCDC37Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:26842. CFAP100.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163885.
PharmGKBiPA142672192.

Polymorphism and mutation databases

BioMutaiCCDC37.
DMDMi97045019.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002344871 – 611Cilia- and flagella-associated protein 100Add BLAST611

Proteomic databases

PaxDbiQ494V2.
PRIDEiQ494V2.

PTM databases

iPTMnetiQ494V2.
PhosphoSitePlusiQ494V2.

Expressioni

Gene expression databases

BgeeiENSG00000163885.
CleanExiHS_CCDC37.
ExpressionAtlasiQ494V2. baseline and differential.
GenevisibleiQ494V2. HS.

Organism-specific databases

HPAiHPA046354.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi131533. 4 interactors.
IntActiQ494V2. 5 interactors.
MINTiMINT-7034511.
STRINGi9606.ENSP00000344749.

Structurei

3D structure databases

ProteinModelPortaliQ494V2.
SMRiQ494V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili101 – 128Sequence analysisAdd BLAST28
Coiled coili164 – 203Sequence analysisAdd BLAST40
Coiled coili230 – 257Sequence analysisAdd BLAST28
Coiled coili393 – 432Sequence analysisAdd BLAST40
Coiled coili526 – 578Sequence analysisAdd BLAST53

Sequence similaritiesi

Belongs to the CFAP100 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFH9. Eukaryota.
ENOG410YEAI. LUCA.
GeneTreeiENSGT00530000063831.
HOGENOMiHOG000007134.
HOVERGENiHBG081040.
InParanoidiQ494V2.
OMAiSPKEWLE.
OrthoDBiEOG091G05I3.
PhylomeDBiQ494V2.
TreeFamiTF328835.

Family and domain databases

InterProiIPR025252. DUF4200.
[Graphical view]
PfamiPF13863. DUF4200. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q494V2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEIPSTIVS KNMTNDKNSL ESMNISSSSS TEENPKKQAR KNEEHGPDPS
60 70 80 90 100
ANPFHLSGDV DFFLLRDQER NKALSERQQQ KTMRVHQKMT YSSKVSAKHT
110 120 130 140 150
SLRRQLQLED KQEDLEARAE AEHQRAFRDY TTWKLTLTKE KNVEPENMSG
160 170 180 190 200
YIKQKRQMFL LQYALDVKRR EIQRLETLAT KEEARLERAE KSLEKDAALF
210 220 230 240 250
DEFVRENDCS SVQAMRAAEK ETKAKIEKIL EIRDLTTQIV NIKSEISRFE
260 270 280 290 300
DTLKHYKVYK DFLYKLSPKE WLEEQEKKHS FLKKAKEVSE ASKESSVNST
310 320 330 340 350
PGDKGPGIKG KASSMWAKEG QGTKKPWRFL QTMRLGRSPS YLSSPQQGSQ
360 370 380 390 400
PSESSGGDSR GSNSPIPPTQ EDTDSDGEEP QLYFTEPQQL LDVFRELEEQ
410 420 430 440 450
NLSLIQNSQE TEKTLEELSH TLKHTQIRMD REVNQLKQWV TTMMMSITKE
460 470 480 490 500
EDTAAELELK ARVFHFGEYK GDQQDKLLES LNCKVLDVYR HCTGTQQEAN
510 520 530 540 550
LGTVQMLTII EHQLDELLEN LEHVPQVKIE QAERAKEKER RIRLREEKLQ
560 570 580 590 600
MQKILQEEHL QRARARAQAE IKKKRGRTLV CRSRPPAHRI KQQSEHTLMD
610
KEEEELLFFF T
Length:611
Mass (Da):71,117
Last modified:September 13, 2005 - v1
Checksum:i34949CC07299588A
GO
Isoform 2 (identifier: Q494V2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-139: K → KA

Note: No experimental confirmation available.
Show »
Length:612
Mass (Da):71,188
Checksum:i6CAD9DFE50B83970
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36K → E in BAC05035 (PubMed:14702039).Curated1
Sequence conflicti244S → G in BAC05035 (PubMed:14702039).Curated1
Sequence conflicti412Missing in AAI01370 (PubMed:15489334).Curated1
Sequence conflicti412Missing in AAI01368 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018328139K → KA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097402 mRNA. Translation: BAC05035.1.
CH471052 Genomic DNA. Translation: EAW79363.1.
CH471052 Genomic DNA. Translation: EAW79364.1.
BC101366 mRNA. Translation: AAI01367.1.
BC101367 mRNA. Translation: AAI01368.2.
BC101368 mRNA. Translation: AAI01369.1.
BC101369 mRNA. Translation: AAI01370.1.
CCDSiCCDS3037.1. [Q494V2-1]
RefSeqiNP_872434.2. NM_182628.2. [Q494V2-1]
XP_006713686.1. XM_006713623.2. [Q494V2-1]
UniGeneiHs.591305.

Genome annotation databases

EnsembliENST00000352312; ENSP00000344749; ENSG00000163885. [Q494V2-1]
ENST00000505024; ENSP00000423046; ENSG00000163885. [Q494V2-2]
GeneIDi348807.
KEGGihsa:348807.
UCSCiuc003eiu.1. human. [Q494V2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097402 mRNA. Translation: BAC05035.1.
CH471052 Genomic DNA. Translation: EAW79363.1.
CH471052 Genomic DNA. Translation: EAW79364.1.
BC101366 mRNA. Translation: AAI01367.1.
BC101367 mRNA. Translation: AAI01368.2.
BC101368 mRNA. Translation: AAI01369.1.
BC101369 mRNA. Translation: AAI01370.1.
CCDSiCCDS3037.1. [Q494V2-1]
RefSeqiNP_872434.2. NM_182628.2. [Q494V2-1]
XP_006713686.1. XM_006713623.2. [Q494V2-1]
UniGeneiHs.591305.

3D structure databases

ProteinModelPortaliQ494V2.
SMRiQ494V2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131533. 4 interactors.
IntActiQ494V2. 5 interactors.
MINTiMINT-7034511.
STRINGi9606.ENSP00000344749.

PTM databases

iPTMnetiQ494V2.
PhosphoSitePlusiQ494V2.

Polymorphism and mutation databases

BioMutaiCCDC37.
DMDMi97045019.

Proteomic databases

PaxDbiQ494V2.
PRIDEiQ494V2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352312; ENSP00000344749; ENSG00000163885. [Q494V2-1]
ENST00000505024; ENSP00000423046; ENSG00000163885. [Q494V2-2]
GeneIDi348807.
KEGGihsa:348807.
UCSCiuc003eiu.1. human. [Q494V2-1]

Organism-specific databases

CTDi348807.
GeneCardsiCCDC37.
H-InvDBHIX0003634.
HIX0003635.
HGNCiHGNC:26842. CFAP100.
HPAiHPA046354.
neXtProtiNX_Q494V2.
OpenTargetsiENSG00000163885.
PharmGKBiPA142672192.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFH9. Eukaryota.
ENOG410YEAI. LUCA.
GeneTreeiENSGT00530000063831.
HOGENOMiHOG000007134.
HOVERGENiHBG081040.
InParanoidiQ494V2.
OMAiSPKEWLE.
OrthoDBiEOG091G05I3.
PhylomeDBiQ494V2.
TreeFamiTF328835.

Miscellaneous databases

GenomeRNAii348807.
PROiQ494V2.

Gene expression databases

BgeeiENSG00000163885.
CleanExiHS_CCDC37.
ExpressionAtlasiQ494V2. baseline and differential.
GenevisibleiQ494V2. HS.

Family and domain databases

InterProiIPR025252. DUF4200.
[Graphical view]
PfamiPF13863. DUF4200. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP100_HUMAN
AccessioniPrimary (citable) accession number: Q494V2
Secondary accession number(s): D3DNA8
, Q494V1, Q494V4, Q8N838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: September 13, 2005
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.