Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cilia- and flagella-associated protein 100

Gene

CFAP100

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 100Curated
Alternative name(s):
Coiled-coil domain-containing protein 37Curated
Gene namesi
Name:CFAP100Imported
Synonyms:CCDC37Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163885.11
HGNCiHGNC:26842 CFAP100
neXtProtiNX_Q494V2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi348807
OpenTargetsiENSG00000163885
PharmGKBiPA142672192

Polymorphism and mutation databases

BioMutaiCCDC37
DMDMi97045019

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002344871 – 611Cilia- and flagella-associated protein 100Add BLAST611

Proteomic databases

EPDiQ494V2
PaxDbiQ494V2
PeptideAtlasiQ494V2
PRIDEiQ494V2
ProteomicsDBi61941
61942 [Q494V2-2]

PTM databases

iPTMnetiQ494V2
PhosphoSitePlusiQ494V2

Expressioni

Gene expression databases

BgeeiENSG00000163885
CleanExiHS_CCDC37
ExpressionAtlasiQ494V2 baseline and differential
GenevisibleiQ494V2 HS

Organism-specific databases

HPAiHPA046354

Interactioni

Protein-protein interaction databases

BioGridi131533, 4 interactors
IntActiQ494V2, 5 interactors
MINTiQ494V2
STRINGi9606.ENSP00000344749

Structurei

3D structure databases

ProteinModelPortaliQ494V2
SMRiQ494V2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili101 – 128Sequence analysisAdd BLAST28
Coiled coili164 – 203Sequence analysisAdd BLAST40
Coiled coili230 – 257Sequence analysisAdd BLAST28
Coiled coili393 – 432Sequence analysisAdd BLAST40
Coiled coili526 – 578Sequence analysisAdd BLAST53

Sequence similaritiesi

Belongs to the CFAP100 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFH9 Eukaryota
ENOG410YEAI LUCA
GeneTreeiENSGT00530000063831
HOGENOMiHOG000007134
HOVERGENiHBG081040
InParanoidiQ494V2
OMAiFGEYKGD
OrthoDBiEOG091G05I3
PhylomeDBiQ494V2
TreeFamiTF328835

Family and domain databases

InterProiView protein in InterPro
IPR025252 DUF4200
PfamiView protein in Pfam
PF13863 DUF4200, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q494V2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEIPSTIVS KNMTNDKNSL ESMNISSSSS TEENPKKQAR KNEEHGPDPS
60 70 80 90 100
ANPFHLSGDV DFFLLRDQER NKALSERQQQ KTMRVHQKMT YSSKVSAKHT
110 120 130 140 150
SLRRQLQLED KQEDLEARAE AEHQRAFRDY TTWKLTLTKE KNVEPENMSG
160 170 180 190 200
YIKQKRQMFL LQYALDVKRR EIQRLETLAT KEEARLERAE KSLEKDAALF
210 220 230 240 250
DEFVRENDCS SVQAMRAAEK ETKAKIEKIL EIRDLTTQIV NIKSEISRFE
260 270 280 290 300
DTLKHYKVYK DFLYKLSPKE WLEEQEKKHS FLKKAKEVSE ASKESSVNST
310 320 330 340 350
PGDKGPGIKG KASSMWAKEG QGTKKPWRFL QTMRLGRSPS YLSSPQQGSQ
360 370 380 390 400
PSESSGGDSR GSNSPIPPTQ EDTDSDGEEP QLYFTEPQQL LDVFRELEEQ
410 420 430 440 450
NLSLIQNSQE TEKTLEELSH TLKHTQIRMD REVNQLKQWV TTMMMSITKE
460 470 480 490 500
EDTAAELELK ARVFHFGEYK GDQQDKLLES LNCKVLDVYR HCTGTQQEAN
510 520 530 540 550
LGTVQMLTII EHQLDELLEN LEHVPQVKIE QAERAKEKER RIRLREEKLQ
560 570 580 590 600
MQKILQEEHL QRARARAQAE IKKKRGRTLV CRSRPPAHRI KQQSEHTLMD
610
KEEEELLFFF T
Length:611
Mass (Da):71,117
Last modified:September 13, 2005 - v1
Checksum:i34949CC07299588A
GO
Isoform 2 (identifier: Q494V2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-139: K → KA

Note: No experimental confirmation available.
Show »
Length:612
Mass (Da):71,188
Checksum:i6CAD9DFE50B83970
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36K → E in BAC05035 (PubMed:14702039).Curated1
Sequence conflicti244S → G in BAC05035 (PubMed:14702039).Curated1
Sequence conflicti412Missing in AAI01370 (PubMed:15489334).Curated1
Sequence conflicti412Missing in AAI01368 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018328139K → KA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097402 mRNA Translation: BAC05035.1
CH471052 Genomic DNA Translation: EAW79363.1
CH471052 Genomic DNA Translation: EAW79364.1
BC101366 mRNA Translation: AAI01367.1
BC101367 mRNA Translation: AAI01368.2
BC101368 mRNA Translation: AAI01369.1
BC101369 mRNA Translation: AAI01370.1
CCDSiCCDS3037.1 [Q494V2-1]
RefSeqiNP_872434.2, NM_182628.2 [Q494V2-1]
XP_006713686.1, XM_006713623.2 [Q494V2-1]
UniGeneiHs.591305

Genome annotation databases

EnsembliENST00000352312; ENSP00000344749; ENSG00000163885 [Q494V2-1]
ENST00000505024; ENSP00000423046; ENSG00000163885 [Q494V2-2]
GeneIDi348807
KEGGihsa:348807
UCSCiuc003eiu.1 human [Q494V2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCP100_HUMAN
AccessioniPrimary (citable) accession number: Q494V2
Secondary accession number(s): D3DNA8
, Q494V1, Q494V4, Q8N838
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: September 13, 2005
Last modified: June 20, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health