Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coiled-coil domain-containing protein 153

Gene

CCDC153

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 153
Gene namesi
Name:CCDC153
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:27446. CCDC153.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000248712.
PharmGKBiPA162381639.

Polymorphism and mutation databases

BioMutaiCCDC153.
DMDMi193806578.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003426501 – 210Coiled-coil domain-containing protein 153Add BLAST210

Proteomic databases

PaxDbiQ494R4.
PeptideAtlasiQ494R4.
PRIDEiQ494R4.

PTM databases

iPTMnetiQ494R4.
PhosphoSitePlusiQ494R4.

Expressioni

Gene expression databases

BgeeiENSG00000248712.
CleanExiHS_CCDC153.
GenevisibleiQ494R4. HS.

Organism-specific databases

HPAiHPA041497.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi129477. 6 interactors.
IntActiQ494R4. 18 interactors.
STRINGi9606.ENSP00000423567.

Structurei

3D structure databases

ProteinModelPortaliQ494R4.
SMRiQ494R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 161Sequence analysisAdd BLAST113

Sequence similaritiesi

Belongs to the UPF0610 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J0FD. Eukaryota.
ENOG4111VS3. LUCA.
GeneTreeiENSGT00390000016289.
HOGENOMiHOG000111395.
HOVERGENiHBG107603.
InParanoidiQ494R4.
OMAiKPQWDGA.
OrthoDBiEOG091G0VY2.
PhylomeDBiQ494R4.
TreeFamiTF343461.

Family and domain databases

InterProiView protein in InterPro
IPR033585. CCDC153.
PANTHERiPTHR28656. PTHR28656. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q494R4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPKNKEKGK KSGAQKKKKN WGADVVAESR HRLVVLEKEL LRDHLALRRD
60 70 80 90 100
EARRAKASED QLRQRLQGVE AELEGARSEG KAIYAEMSRQ CHALQEDMQT
110 120 130 140 150
RSKQLEEEVK GLRGQLEACQ REAAAAREEA EQALGERDQA LAQLRAHMAD
160 170 180 190 200
MEAKYEEILH DSLDRLLAKL RAIKQQWDGA ALRLHARHKE QQRQFGLTPP
210
GSLRPPAPSL
Length:210
Mass (Da):23,858
Last modified:July 1, 2008 - v2
Checksum:iFA763254E95386B3
GO
Isoform 2 (identifier: Q494R4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.

Show »
Length:124
Mass (Da):14,088
Checksum:iC8DFBCF358FF0FA0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044322101R → H1 PublicationCorresponds to variant dbSNP:rs2301574Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0345181 – 86Missing in isoform 2. 1 PublicationAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002956 Genomic DNA. No translation available.
BC101443 mRNA. Translation: AAI01444.1.
BC101444 mRNA. Translation: AAI01445.1.
BC101986 mRNA. Translation: AAI01987.1.
CCDSiCCDS44753.1. [Q494R4-1]
RefSeqiNP_001138490.1. NM_001145018.1. [Q494R4-1]
XP_011541072.1. XM_011542770.2. [Q494R4-1]
XP_016873069.1. XM_017017580.1. [Q494R4-1]
UniGeneiHs.114777.

Genome annotation databases

EnsembliENST00000415318; ENSP00000445431; ENSG00000248712. [Q494R4-1]
ENST00000503566; ENSP00000423567; ENSG00000248712. [Q494R4-1]
GeneIDi283152.
KEGGihsa:283152.
UCSCiuc058ihx.1. human. [Q494R4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCC153_HUMAN
AccessioniPrimary (citable) accession number: Q494R4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: August 30, 2017
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries