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Protein

Coiled-coil domain-containing protein 153

Gene

CCDC153

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 153
Gene namesi
Name:CCDC153
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:27446. CCDC153.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381639.

Polymorphism and mutation databases

BioMutaiCCDC153.
DMDMi193806578.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Coiled-coil domain-containing protein 153PRO_0000342650Add
BLAST

Proteomic databases

EPDiQ494R4.
PaxDbiQ494R4.
PRIDEiQ494R4.

PTM databases

PhosphoSiteiQ494R4.

Expressioni

Gene expression databases

BgeeiQ494R4.
CleanExiHS_CCDC153.
GenevisibleiQ494R4. HS.

Organism-specific databases

HPAiHPA041497.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDR2Q018503EBI-10241443,EBI-1181367
DDIT3P35638-23EBI-10241443,EBI-10173632
DTNBP1Q96EV83EBI-10241443,EBI-465804
GORASP2Q9H8Y83EBI-10241443,EBI-739467
NECAB2H3BTW23EBI-10241443,EBI-10172876
NUP62P371983EBI-10241443,EBI-347978

Protein-protein interaction databases

BioGridi129477. 6 interactions.
IntActiQ494R4. 6 interactions.
STRINGi9606.ENSP00000423567.

Structurei

3D structure databases

ProteinModelPortaliQ494R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili49 – 161113Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0610 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J0FD. Eukaryota.
ENOG4111VS3. LUCA.
GeneTreeiENSGT00390000016289.
HOGENOMiHOG000111395.
HOVERGENiHBG107603.
InParanoidiQ494R4.
OMAiQFGLNPL.
OrthoDBiEOG7ZPNN7.
PhylomeDBiQ494R4.
TreeFamiTF343461.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q494R4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPKNKEKGK KSGAQKKKKN WGADVVAESR HRLVVLEKEL LRDHLALRRD
60 70 80 90 100
EARRAKASED QLRQRLQGVE AELEGARSEG KAIYAEMSRQ CHALQEDMQT
110 120 130 140 150
RSKQLEEEVK GLRGQLEACQ REAAAAREEA EQALGERDQA LAQLRAHMAD
160 170 180 190 200
MEAKYEEILH DSLDRLLAKL RAIKQQWDGA ALRLHARHKE QQRQFGLTPP
210
GSLRPPAPSL
Length:210
Mass (Da):23,858
Last modified:July 1, 2008 - v2
Checksum:iFA763254E95386B3
GO
Isoform 2 (identifier: Q494R4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.

Show »
Length:124
Mass (Da):14,088
Checksum:iC8DFBCF358FF0FA0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti101 – 1011R → H.1 Publication
Corresponds to variant rs2301574 [ dbSNP | Ensembl ].
VAR_044322

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8686Missing in isoform 2. 1 PublicationVSP_034518Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002956 Genomic DNA. No translation available.
BC101443 mRNA. Translation: AAI01444.1.
BC101444 mRNA. Translation: AAI01445.1.
BC101986 mRNA. Translation: AAI01987.1.
CCDSiCCDS44753.1. [Q494R4-1]
RefSeqiNP_001138490.1. NM_001145018.1. [Q494R4-1]
XP_011541061.1. XM_011542759.1. [Q494R4-1]
XP_011541072.1. XM_011542770.1. [Q494R4-1]
UniGeneiHs.114777.

Genome annotation databases

EnsembliENST00000415318; ENSP00000445431; ENSG00000248712. [Q494R4-1]
ENST00000503566; ENSP00000423567; ENSG00000248712. [Q494R4-1]
GeneIDi283152.
KEGGihsa:283152.
UCSCiuc058ihx.1. human. [Q494R4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002956 Genomic DNA. No translation available.
BC101443 mRNA. Translation: AAI01444.1.
BC101444 mRNA. Translation: AAI01445.1.
BC101986 mRNA. Translation: AAI01987.1.
CCDSiCCDS44753.1. [Q494R4-1]
RefSeqiNP_001138490.1. NM_001145018.1. [Q494R4-1]
XP_011541061.1. XM_011542759.1. [Q494R4-1]
XP_011541072.1. XM_011542770.1. [Q494R4-1]
UniGeneiHs.114777.

3D structure databases

ProteinModelPortaliQ494R4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129477. 6 interactions.
IntActiQ494R4. 6 interactions.
STRINGi9606.ENSP00000423567.

PTM databases

PhosphoSiteiQ494R4.

Polymorphism and mutation databases

BioMutaiCCDC153.
DMDMi193806578.

Proteomic databases

EPDiQ494R4.
PaxDbiQ494R4.
PRIDEiQ494R4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415318; ENSP00000445431; ENSG00000248712. [Q494R4-1]
ENST00000503566; ENSP00000423567; ENSG00000248712. [Q494R4-1]
GeneIDi283152.
KEGGihsa:283152.
UCSCiuc058ihx.1. human. [Q494R4-1]

Organism-specific databases

CTDi283152.
GeneCardsiCCDC153.
HGNCiHGNC:27446. CCDC153.
HPAiHPA041497.
neXtProtiNX_Q494R4.
PharmGKBiPA162381639.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0FD. Eukaryota.
ENOG4111VS3. LUCA.
GeneTreeiENSGT00390000016289.
HOGENOMiHOG000111395.
HOVERGENiHBG107603.
InParanoidiQ494R4.
OMAiQFGLNPL.
OrthoDBiEOG7ZPNN7.
PhylomeDBiQ494R4.
TreeFamiTF343461.

Miscellaneous databases

GenomeRNAii283152.
NextBioi93668.
PROiQ494R4.

Gene expression databases

BgeeiQ494R4.
CleanExiHS_CCDC153.
GenevisibleiQ494R4. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT HIS-101.

Entry informationi

Entry nameiCC153_HUMAN
AccessioniPrimary (citable) accession number: Q494R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: March 16, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.