ID   HIS4_BLOPB              Reviewed;         246 AA.
AC   Q494D7;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
DE            EC=5.3.1.16;
DE   AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
GN   Name=hisA; OrderedLocusNames=BPEN_482;
OS   Blochmannia pennsylvanicus (strain BPEN).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; ant endosymbionts; Candidatus Blochmannia.
OX   NCBI_TaxID=291272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16077009; DOI=10.1101/gr.3771305;
RA   Degnan P.H., Lazarus A.B., Wernegreen J.J.;
RT   "Genome sequence of Blochmannia pennsylvanicus indicates parallel
RT   evolutionary trends among bacterial mutualists of insects.";
RL   Genome Res. 15:1023-1033(2005).
CC   -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-5-((5-
CC       phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-
CC       ((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-
CC       phosphoribosyl)imidazole-4-carboxamide.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the hisA/hisF family.
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DR   EMBL; CP000016; AAZ41097.1; -; Genomic_DNA.
DR   RefSeq; YP_277974.1; -.
DR   GeneID; 3562989; -.
DR   GenomeReviews; CP000016_GR; BPEN_482.
DR   KEGG; bpn:BPEN_482; -.
DR   HOGENOM; Q494D7; -.
DR   OMA; Q494D7; VATRGWL.
DR   BioCyc; CBLO291272:BPEN_482-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylam...; IEA:HAMAP.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01014; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006062; His_biosynth.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF00977; His_biosynth; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Isomerase.
FT   CHAIN         1    246       1-(5-phosphoribosyl)-5-[(5-
FT                                phosphoribosylamino)methylideneamino]
FT                                imidazole-4-carboxamide isomerase.
FT                                /FTId=PRO_0000229043.
FT   ACT_SITE      7      7       Proton acceptor (By similarity).
FT   ACT_SITE    130    130       Proton donor (By similarity).
SQ   SEQUENCE   246 AA;  27442 MW;  5CDB815E4E0C198C CRC64;
     MIIPALDIIN GNIVRLYQGS YCMQTNYGEP ISLLKEYIRQ GAKMIHLVDL DGAKNPLKRQ
     SLLISQLIKE ANPLSKIQIG GGIRNASDVE ILLESGATRI VLGSIAVTQP KIVKKWFEYF
     DPNTLVLAVD IHVYSEENRK VAIYGWQKET DLQLEQIIEE YYTVGLKHVI CTDISKDGTL
     LGSNISLYRS ICHAWPRIAF QSSGGVNKLS EISKLRSSGV AGIIIGRAFL ENTFTINEAI
     SCWQNE
//