Reviewed, UniProtKB/Swiss-Prot Q494D7 (HIS4_BLOPB)

Names and origin

Protein names

Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
    EC=5.3.1.16
Alternative name(s):
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Gene names

Name:	hisA
Ordered Locus Names:	BPEN_482

Organism

Blochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]

Taxonomic identifier

291272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide. HAMAP MF_01014
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP MF_01014
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the hisA/hisF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HAMAP MF_01014		PRO_0000229043
Sites
	Active site	7	1	Proton acceptor By similarity
	Active site	130	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q494D7-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 5CDB815E4E0C198C	FASTA	246	27,442
	10 20 30 40 50 60 MIIPALDIIN GNIVRLYQGS YCMQTNYGEP ISLLKEYIRQ GAKMIHLVDL DGAKNPLKRQ 70 80 90 100 110 120 SLLISQLIKE ANPLSKIQIG GGIRNASDVE ILLESGATRI VLGSIAVTQP KIVKKWFEYF 130 140 150 160 170 180 DPNTLVLAVD IHVYSEENRK VAIYGWQKET DLQLEQIIEE YYTVGLKHVI CTDISKDGTL 190 200 210 220 230 240 LGSNISLYRS ICHAWPRIAF QSSGGVNKLS EISKLRSSGV AGIIIGRAFL ENTFTINEAI SCWQNE

References

[1]	"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects." Degnan P.H., Lazarus A.B., Wernegreen J.J. Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000016 Genomic DNA. Translation: AAZ41097.1.
RefSeq	YP_277974.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3562989.
GenomeReviews	Gene locus BPEN_482 in contig CP000016_GR.
KEGG	bpn:BPEN_482.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q494D7.
OMA	Q494D7. VATRGWL.
Enzyme and pathway databases
BioCyc	CBLO291272:BPEN_482-MON.
Family and domain databases
HAMAP	MF_01014. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006062. His_biosynth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00977. His_biosynth. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS4_BLOPB

Accession

Primary (citable) accession number: Q494D7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)