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Protein

Putative phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase (plsC)
  3. Putative phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Ordered Locus Names:MG437
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000807 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei288 – 310HelicalSequence analysisAdd BLAST23
Transmembranei317 – 339HelicalSequence analysisAdd BLAST23
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Not essential, it can be deleted.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907391 – 397Putative phosphatidate cytidylyltransferaseAdd BLAST397

Proteomic databases

PRIDEiQ49433

Interactioni

Protein-protein interaction databases

STRINGi243273.MgenG_010200000280

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107WZU Bacteria
COG0575 LUCA
KOiK00981
OrthoDBiPOG091H001F

Family and domain databases

InterProiView protein in InterPro
IPR000374 PC_trans
PROSITEiView protein in PROSITE
PS01315 CDS, 1 hit

Sequencei

Sequence statusi: Complete.

Q49433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEKAKQFIK KRTSVFIALL VVFCFFLLIS AFADGFNFWS PWSADFNSRT
60 70 80 90 100
LKVEQASGVT SVISTEINEN FKAVRFSFSI IIILIVGVIG SLMIWELFTN
110 120 130 140 150
ILKNKPKLSL SLTLLNAGII IFGMIGTFVV VYFYKWNATV NGIWTLSFTL
160 170 180 190 200
SVVLLWIIYI ACMSKTRIKF SLQLSYSLGA IACFIASIGT IYFSVIRGWT
210 220 230 240 250
TIFLLMSLAV SVDTFSFLFG KRFGKNPLIK ISPSKTWEGA FFGIISTIVV
260 270 280 290 300
VALLCVLYSI PFFVAKPTFN QTNGIALNTP QNYDSHNLIT NIFLIAFISG
310 320 330 340 350
GSSFYIYWWV STLALIFTGS VFAIGGDLFF SYIKRLISIK DFSKVLGKHG
360 370 380 390
GVLDRFDSSS FLISFFFVYH LIAGTISNQR LLMEPNTYFS AITSIQS
Length:397
Mass (Da):44,484
Last modified:January 31, 2018 - v2
Checksum:iD2591CFF7663A58E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC72458.2
U02189 Genomic DNA Translation: AAD12473.1
PIRiT09771
RefSeqiWP_009885597.1, NZ_AAGX01000001.1

Genome annotation databases

EnsemblBacteriaiAAC72458; AAC72458; MG_437
KEGGimge:MG_437

Similar proteinsi

Entry informationi

Entry nameiCDSA_MYCGE
AccessioniPrimary (citable) accession number: Q49433
Secondary accession number(s): Q49309
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 31, 2018
Last modified: May 23, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health