Reviewed, UniProtKB/Swiss-Prot Q49433 (CDSA_MYCGE)

Names and origin

Protein names

Recommended name:
    Putative phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	MG437

Organism

Mycoplasma genitalium [Complete proteome] [HAMAP]

Taxonomic identifier

2097 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Putative phosphatidate cytidylyltransferase		PRO_0000090739
Regions
	Transmembrane	22 – 42	21	Potential
	Transmembrane	51 – 71	21	Potential
	Transmembrane	84 – 104	21	Potential
	Transmembrane	107 – 127	21	Potential
	Transmembrane	152 – 172	21	Potential
	Transmembrane	212 – 232	21	Potential
	Transmembrane	264 – 284	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q49433-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: F149FA6BD9DDC080	FASTA	305	34,196
	10 20 30 40 50 60 MIWELFTNIL KNKPKLSLSL TLLNAGIIIF GMIGTFVVVY FYKWNATVNG IWTLSFTLSV 70 80 90 100 110 120 VLLWIIYIAC MSKTRIKFSL QLSYSLGAIA CFIASIGTIY FSVIRGWTTI FLLMSLAVSV 130 140 150 160 170 180 DTFPFLFGKR FGKNPLIKIS PSKTWEGAFF GIISTIVVVA LLCVLYSIPF FVAKPTFNQT 190 200 210 220 230 240 NGIALNTPQN YDSHNLITNI FLIAFISGGS SFYIYWWVST LALIFTGSVF AIGGDLFFSY 250 260 270 280 290 300 IKRLISIKDF SKVLGKHGGV LDRFDSSSFL ISFFFVYHLI AGTISNQRLL MEPNTYFSAI TSIQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"A survey of the Mycoplasma genitalium genome by using random sequencing." Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III J. Bacteriol. 175:7918-7930(1993) [PubMed: 8253680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-226. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L43967 Genomic DNA. Translation: AAC72458.1. Different initiation. U02189 Genomic DNA. Translation: AAD12473.1.
PIR	T09771.
RefSeq	NP_073107.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	875619.
GenomeReviews	Gene locus MG437 in contig L43967_GR.
KEGG	mge:MG_437.
TIGR	MG437.
Phylogenomic databases
HOGENOM	Q49433.
Enzyme and pathway databases
BioCyc	MGEN243273:MG_437-MON.
BRENDA	2.7.7.41. 110.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_MYCGE

Accession

Primary (citable) accession number: Q49433
Secondary accession number(s): Q49309

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	October 13, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)