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Q49420

- CSD_MYCGE

UniProt

Q49420 - CSD_MYCGE

Protein

Probable cysteine desulfurase

Gene

csd

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.By similarity

    Catalytic activityi

    L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor.

    Cofactori

    Pyridoxal phosphate.By similarity

    GO - Molecular functioni

    1. cysteine desulfurase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-386-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cysteine desulfurase (EC:2.8.1.7)
    Gene namesi
    Name:csd
    Ordered Locus Names:MG336
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Probable cysteine desulfurasePRO_0000150299Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei225 – 2251N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi243273.MG_336.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49420.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0520.
    KOiK11717.
    OMAiFRQAFPY.
    OrthoDBiEOG68DD0M.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR020578. Aminotrans_V_PyrdxlP_BS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q49420-1 [UniParc]FASTAAdd to Basket

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    MSAIKFNPSS FRKNFKWFEN NKNWINFDNA ATSIALDVVA EASKEYYQYF    50
    CVNPHNKNPE INQKLIAIIE ETRDLLAKFF NAKKNEIIFT SSATESLNLF 100
    AFGLSSLVKS NDEIILKEDE HAANVFPWVN LAKENKAKLK IIKKTPNKSW 150
    TDAFLKACTP STKLLVITAT SNLFGNSIDY EKISKHLKKI SPNSFIVVDA 200
    VQAVPHHKID ITSANIDFLT FSTHKFYGPT GLGIAFIKSE LQSRLKPFKL 250
    GGDIFKSLDN NFKIIFKEGP SKFEAGTLNI MAIYALNKQL KFMQKEFNFS 300
    EMVFYSKQLK NLAYQLLSQN PNIVLANHDQ DVPIFAFKHK YINSADLATF 350
    LNIKKIIVRQ GSICVGKFKN KESFLRVSLL HYNTKEELLY LEKLLKTSKN 400
    SIINELIY 408
    Length:408
    Mass (Da):46,618
    Last modified:November 1, 1996 - v1
    Checksum:iF16A009B463EBDAD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71561.1.
    U02256 Genomic DNA. Translation: AAD12521.1.
    PIRiB64237.
    RefSeqiNP_073006.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71561; AAC71561; MG_336.
    GeneIDi875461.
    KEGGimge:MG_336.
    PATRICi20010232. VBIMycGen98045_0393.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71561.1 .
    U02256 Genomic DNA. Translation: AAD12521.1 .
    PIRi B64237.
    RefSeqi NP_073006.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali Q49420.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_336.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71561 ; AAC71561 ; MG_336 .
    GeneIDi 875461.
    KEGGi mge:MG_336.
    PATRICi 20010232. VBIMycGen98045_0393.

    Phylogenomic databases

    eggNOGi COG0520.
    KOi K11717.
    OMAi FRQAFPY.
    OrthoDBi EOG68DD0M.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-386-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR020578. Aminotrans_V_PyrdxlP_BS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00595. AA_TRANSFER_CLASS_5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
      Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
      J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 241-330.
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiCSD_MYCGE
    AccessioniPrimary (citable) accession number: Q49420
    Secondary accession number(s): Q49361
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3