Reviewed,
UniProtKB/Swiss-Prot Q49408 (NAOX_MYCGE)
Last modified
January 19, 2010.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable NADH oxidase Short name=NOXase EC=1.6.99.3 | ||||
| Gene names |
| ||||
| Organism | Mycoplasma genitalium [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 2097 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma |
Protein attributes
| Sequence length | 478 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the four-electron reduction of molecular oxygen to water By similarity. |
| Catalytic activity | NADH + acceptor = NAD+ + reduced acceptor. |
| Cofactor | Binds 1 FAD per subunit By similarity. |
| Sequence similarities | Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family. |
Ontologies
| Keywords | |
|---|---|
| Domain | Redox-active center |
| Ligand | FAD Flavoprotein NAD |
| Molecular function | Oxidoreductase |
| PTM | Oxidation |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: InterPro |
| Molecular function | FAD binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 478 | 478 | Probable NADH oxidase | PRO_0000184702 | |||||
Regions | |||||||||
| Nucleotide binding | 8 – 12 | 5 | FAD By similarity | ||||||
| Nucleotide binding | 111 – 114 | 4 | FAD By similarity | ||||||
| Nucleotide binding | 170 – 185 | 16 | NAD By similarity | ||||||
| Nucleotide binding | 295 – 305 | 11 | FAD By similarity | ||||||
Sites | |||||||||
| Active site | 11 | 1 | Proton acceptor By similarity | ||||||
| Active site | 43 | 1 | Redox-active | ||||||
| Binding site | 43 | 1 | FAD By similarity | ||||||
| Binding site | 197 | 1 | NAD By similarity | ||||||
| Binding site | 264 | 1 | NAD; via amide nitrogen By similarity | ||||||
| Binding site | 323 | 1 | FAD; via amide nitrogen By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 43 | 1 | Cysteine sulfenic acid (-SOH) By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 28 | 1 | K → P in AAD10607. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. Venter J.C.Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195. |
| [2] | "A survey of the Mycoplasma genitalium genome by using random sequencing." Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III J. Bacteriol. 175:7918-7930(1993) [PubMed: 8253680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28. Strain: ATCC 33530 / G-37 / NCTC 10195. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L43967 Genomic DNA. Translation: AAC71497.1. U01786 Genomic DNA. Translation: AAD10607.1. Different initiation. |
| PIR | D64230. |
| RefSeq | NP_072942.2. |
3D structure databases | |
| SMR | Q49408. Positions 1-464. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 875557. |
| GenomeReviews | Gene locus MG275 in contig L43967_GR. |
| KEGG | mge:MG_275. |
| TIGR | MG275. |
Phylogenomic databases | |
| HOGENOM | HBG535576. |
Enzyme and pathway databases | |
| BioCyc | MGEN243273:MG_275-MONOMER. |
| BRENDA | 1.6.99.3. 110. |
Family and domain databases | |
| InterPro | IPR016156. FAD/NAD-linked_Rdtase_dimer. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view] |
| Gene3D | G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit. |
| Pfam | PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view] |
| PRINTS | PR00368. FADPNR. |
| ProtoNet | Search... |
Entry information
| Entry name | NAOX_MYCGE | ||||||||
| Accession | Primary (citable) accession number: Q49408 Secondary accession number(s): Q49235 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Mycoplasma genitalium Mycoplasma genitalium (strain G-37): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


