Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q49408 (NAOX_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable NADH oxidase
Short name=NOXase
EC=1.6.99.3
Gene names
Name:nox
Ordered Locus Names:MG275
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma ›

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the four-electron reduction of molecular oxygen to water By similarity.

Catalytic activity

NADH + acceptor = NAD+ + reduced acceptor.

Cofactor

Binds 1 FAD per subunit By similarity.

Sequence similarities

Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

Sequence caution

The sequence AAD10607.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   DomainRedox-active center
   LigandFAD
Flavoprotein
NAD
   Molecular functionOxidoreductase
   PTMOxidation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functionNADH dehydrogenase activity

Inferred from electronic annotation. Source: EC

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478Probable NADH oxidase
PRO_0000184702

Regions

Nucleotide binding8 – 125FAD By similarity
Nucleotide binding111 – 1144FAD By similarity
Nucleotide binding170 – 18516NAD By similarity
Nucleotide binding295 – 30511FAD By similarity

Sites

Active site111Proton acceptor By similarity
Active site431Redox-active
Binding site431FAD By similarity
Binding site1971NAD By similarity
Binding site2641NAD; via amide nitrogen By similarity
Binding site3231FAD; via amide nitrogen By similarity

Amino acid modifications

Modified residue431Cysteine sulfenic acid (-SOH) By similarity

Experimental info

Sequence conflict281K → P in AAD10607. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q49408 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: A96A76F64DEBD0C8

FASTA47853,173
        10         20         30         40         50         60 
MKKVIVIGIN HAGTSFIRTL LSKSKDFKVN AYDRNTNISF LGCGIALAVS GVVKNTDDLF 

        70         80         90        100        110        120 
YSNPEELKQM GANIFMSHDV TNIDLIKKQV TVRDLTSNKE FTDQFDQLVI ASGAWPICMN 

       130        140        150        160        170        180 
VENKVTHKPL EFNYTDKYCG NVKNLISCKL YQHALTLIDS FRKDKTIKSV AIVGSGYIGL 

       190        200        210        220        230        240 
ELAEAAWLCK KQVTVIDLLD KPAGNNFDHE FTDELEKVMQ KDGLKLMMGC SVKGFVVDST 

       250        260        270        280        290        300 
NNVVKGVETD KGIVNADLVN QSIGFRPSTK FVPKDQNFEF IHNGSIKVNE FLQALNHKDV 

       310        320        330        340        350        360 
YVIGGCAAIY NAASEQYENI DLATNAVKSG LVAAMHIIGS NQVKLQSIVG TNALHIFGLN 

       370        380        390        400        410        420 
LAACGLTEQR AKKLGFDVGI SVVDDNDRPE FMGSYDKVRF KLVYDKKTLR ILGAQLLSWN 

       430        440        450        460        470 
TNHSEIIFYI ALAIQKQMLL TELGLVDVYF LPHYNKPFNF VLATVLQALG FSYYIPKK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L43967 Genomic DNA. Translation: AAC71497.1.
U01786 Genomic DNA. Translation: AAD10607.1. Different initiation.
PIRD64230.
RefSeqNP_072942.2. NC_000908.2.

3D structure databases

ProteinModelPortalQ49408.
ModBaseSearch...

Protein-protein interaction databases

STRING243273.MG_275.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71497; AAC71497; MG_275.
GeneID875557.
KEGGmge:MG_275.
PATRIC20010050. VBIMycGen98045_0317.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0446.
KOK03885.
ProtClustDBCLSK437127.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-323-MONOMER.

Family and domain databases

Gene3D3.30.390.30. 1 hit.
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNAOX_MYCGE
AccessionPrimary (citable) accession number: Q49408
Secondary accession number(s): Q49235
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents