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Protein

Probable NADH oxidase

Gene

nox

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the four-electron reduction of molecular oxygen to water.By similarity

Catalytic activityi

NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11Proton acceptorBy similarity1
Active sitei43Redox-active1
Binding sitei43FADBy similarity1
Binding sitei197NADBy similarity1
Binding sitei264NAD; via amide nitrogenBy similarity1
Binding sitei323FAD; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 12FADBy similarity5
Nucleotide bindingi111 – 114FADBy similarity4
Nucleotide bindingi170 – 185NADBy similarityAdd BLAST16
Nucleotide bindingi295 – 305FADBy similarityAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADH oxidase (EC:1.6.99.3)
Short name:
NOXase
Gene namesi
Name:nox
Ordered Locus Names:MG275
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000807 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001847021 – 478Probable NADH oxidaseAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43Cysteine sulfenic acid (-SOH)By similarity1

Keywords - PTMi

Oxidation

Interactioni

Protein-protein interaction databases

STRINGi243273.MgenG_010200002659.

Structurei

3D structure databases

ProteinModelPortaliQ49408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4107QMW. Bacteria.
COG0446. LUCA.
OrthoDBiPOG091H02KF.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVIVIGIN HAGTSFIRTL LSKSKDFKVN AYDRNTNISF LGCGIALAVS
60 70 80 90 100
GVVKNTDDLF YSNPEELKQM GANIFMSHDV TNIDLIKKQV TVRDLTSNKE
110 120 130 140 150
FTDQFDQLVI ASGAWPICMN VENKVTHKPL EFNYTDKYCG NVKNLISCKL
160 170 180 190 200
YQHALTLIDS FRKDKTIKSV AIVGSGYIGL ELAEAAWLCK KQVTVIDLLD
210 220 230 240 250
KPAGNNFDHE FTDELEKVMQ KDGLKLMMGC SVKGFVVDST NNVVKGVETD
260 270 280 290 300
KGIVNADLVN QSIGFRPSTK FVPKDQNFEF IHNGSIKVNE FLQALNHKDV
310 320 330 340 350
YVIGGCAAIY NAASEQYENI DLATNAVKSG LVAAMHIIGS NQVKLQSIVG
360 370 380 390 400
TNALHIFGLN LAACGLTEQR AKKLGFDVGI SVVDDNDRPE FMGSYDKVRF
410 420 430 440 450
KLVYDKKTLR ILGAQLLSWN TNHSEIIFYI ALAIQKQMLL TELGLVDVYF
460 470
LPHYNKPFNF VLATVLQALG FSYYIPKK
Length:478
Mass (Da):53,173
Last modified:November 1, 1997 - v1
Checksum:iA96A76F64DEBD0C8
GO

Sequence cautioni

The sequence AAD10607 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28K → P in AAD10607 (PubMed:8253680).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71497.1.
U01786 Genomic DNA. Translation: AAD10607.1. Different initiation.
PIRiD64230.

Genome annotation databases

EnsemblBacteriaiAAC71497; AAC71497; MG_275.
KEGGimge:MG_275.
PATRICi20010050. VBIMycGen98045_0317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71497.1.
U01786 Genomic DNA. Translation: AAD10607.1. Different initiation.
PIRiD64230.

3D structure databases

ProteinModelPortaliQ49408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243273.MgenG_010200002659.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC71497; AAC71497; MG_275.
KEGGimge:MG_275.
PATRICi20010050. VBIMycGen98045_0317.

Phylogenomic databases

eggNOGiENOG4107QMW. Bacteria.
COG0446. LUCA.
OrthoDBiPOG091H02KF.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNAOX_MYCGE
AccessioniPrimary (citable) accession number: Q49408
Secondary accession number(s): Q49235
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.