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Q49408

- NAOX_MYCGE

UniProt

Q49408 - NAOX_MYCGE

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Protein
Probable NADH oxidase
Gene
nox, MG275
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the four-electron reduction of molecular oxygen to water By similarity.

Catalytic activityi

NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

Binds 1 FAD per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111Proton acceptor By similarity
Active sitei43 – 431Redox-active
Binding sitei43 – 431FAD By similarity
Binding sitei197 – 1971NAD By similarity
Binding sitei264 – 2641NAD; via amide nitrogen By similarity
Binding sitei323 – 3231FAD; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 125FAD By similarity
Nucleotide bindingi111 – 1144FAD By similarity
Nucleotide bindingi170 – 18516NAD By similarity
Add
BLAST
Nucleotide bindingi295 – 30511FAD By similarity
Add
BLAST

GO - Molecular functioni

  1. NADH dehydrogenase activity Source: UniProtKB-EC
  2. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-304-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADH oxidase (EC:1.6.99.3)
Short name:
NOXase
Gene namesi
Name:nox
Ordered Locus Names:MG275
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Probable NADH oxidase
PRO_0000184702Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Protein-protein interaction databases

STRINGi243273.MG_275.

Structurei

3D structure databases

ProteinModelPortaliQ49408.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0446.
KOiK03885.
OrthoDBiEOG6QVRCJ.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
SUPFAMiSSF55424. SSF55424. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49408-1 [UniParc]FASTAAdd to Basket

« Hide

MKKVIVIGIN HAGTSFIRTL LSKSKDFKVN AYDRNTNISF LGCGIALAVS    50
GVVKNTDDLF YSNPEELKQM GANIFMSHDV TNIDLIKKQV TVRDLTSNKE 100
FTDQFDQLVI ASGAWPICMN VENKVTHKPL EFNYTDKYCG NVKNLISCKL 150
YQHALTLIDS FRKDKTIKSV AIVGSGYIGL ELAEAAWLCK KQVTVIDLLD 200
KPAGNNFDHE FTDELEKVMQ KDGLKLMMGC SVKGFVVDST NNVVKGVETD 250
KGIVNADLVN QSIGFRPSTK FVPKDQNFEF IHNGSIKVNE FLQALNHKDV 300
YVIGGCAAIY NAASEQYENI DLATNAVKSG LVAAMHIIGS NQVKLQSIVG 350
TNALHIFGLN LAACGLTEQR AKKLGFDVGI SVVDDNDRPE FMGSYDKVRF 400
KLVYDKKTLR ILGAQLLSWN TNHSEIIFYI ALAIQKQMLL TELGLVDVYF 450
LPHYNKPFNF VLATVLQALG FSYYIPKK 478
Length:478
Mass (Da):53,173
Last modified:November 1, 1997 - v1
Checksum:iA96A76F64DEBD0C8
GO

Sequence cautioni

The sequence AAD10607.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281K → P in AAD10607. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71497.1.
U01786 Genomic DNA. Translation: AAD10607.1. Different initiation.
PIRiD64230.
RefSeqiNP_072942.2. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71497; AAC71497; MG_275.
GeneIDi875557.
KEGGimge:MG_275.
PATRICi20010050. VBIMycGen98045_0317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71497.1 .
U01786 Genomic DNA. Translation: AAD10607.1 . Different initiation.
PIRi D64230.
RefSeqi NP_072942.2. NC_000908.2.

3D structure databases

ProteinModelPortali Q49408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_275.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71497 ; AAC71497 ; MG_275 .
GeneIDi 875557.
KEGGi mge:MG_275.
PATRICi 20010050. VBIMycGen98045_0317.

Phylogenomic databases

eggNOGi COG0446.
KOi K03885.
OrthoDBi EOG6QVRCJ.

Enzyme and pathway databases

BioCyci MGEN243273:GH2R-304-MONOMER.

Family and domain databases

Gene3Di 3.30.390.30. 1 hit.
InterProi IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view ]
Pfami PF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view ]
PRINTSi PR00368. FADPNR.
SUPFAMi SSF55424. SSF55424. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiNAOX_MYCGE
AccessioniPrimary (citable) accession number: Q49408
Secondary accession number(s): Q49235
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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