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Q49405

- DPO3A_MYCGE

UniProt

Q49405 - DPO3A_MYCGE

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Protein
DNA polymerase III subunit alpha
Gene
dnaE, MG261
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase By similarity.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. 3'-5' exonuclease activity Source: InterPro
  2. DNA binding Source: InterPro
  3. DNA-directed DNA polymerase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-287-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit alpha (EC:2.7.7.7)
Gene namesi
Name:dnaE
Ordered Locus Names:MG261
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874DNA polymerase III subunit alpha
PRO_0000103326Add
BLAST

Interactioni

Subunit structurei

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.

Protein-protein interaction databases

STRINGi243273.MG_261.

Structurei

3D structure databases

ProteinModelPortaliQ49405.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0587.
KOiK02337.
OMAiARINFIV.
OrthoDBiEOG6CZQGR.

Family and domain databases

InterProiIPR011708. DNA_pol3_alpha.
IPR004013. PHP_C.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
IPR004805. PolC_alpha.
[Graphical view]
PfamiPF07733. DNA_pol3_alpha. 1 hit.
PF02811. PHP. 1 hit.
[Graphical view]
SMARTiSM00481. POLIIIAc. 1 hit.
[Graphical view]
SUPFAMiSSF89550. SSF89550. 1 hit.
TIGRFAMsiTIGR00594. polc. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49405-1 [UniParc]FASTAAdd to Basket

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MFVNLHTNSY YNFLNSALSP KKLVNLAIND QQKAVAITDP NLFGAVEFFI    50
TCKQNNIKPI IGLNLTVEYQ KNDVKLLLIA KSNKGFQTLN KIALIQQKLE 100
INSLVDQLTD IAVIICSLTT WKSTYKDVYQ AKGIEINQTP IAILANAVNC 150
EKTNSDQVVL TVLKQMKQNQ TGKITTFDWD LKQKLNQISI NENLKVKSEI 200
QPFLDQKTAQ QLFSETELNN LNDLVNRCEL DLEHLKAASL SLTDNDAAVL 250
ESLCQTNLKQ FLDKNQDLNK KAYQLRLEKE LNVINKLNFA SYFLVVNDLV 300
NYAFKKDILI GSGRGSAVGS LVAFLLNITK IDPVQHQLIF ERFISTHRQD 350
LPDIDIDIME NKRAEMINYL FEKYGKENCA QIVTFQRFKT RSAVKEVAKL 400
FNDYGISDMI LGVLPKDQTI TFTDLKATED SALQLCLQQF GLIVELALAI 450
VDFPRQSSIH ASGIVIASNS LIKTIPLLQL DNNHFLTQVS MEWLSFFNLN 500
KFDLLGLINL TMISDVITQI KPSNQTVNQF LNTISWTDQN TFINLVNEDT 550
LGIFQLESFG MKKLLVQIKP KTINQLAIVL ALYRPGAQDN INLFINRLHN 600
GYDQSDIDPR ILPIVKNTYG VLIFQEQIIN IVKVVANYSL EEADSFRRAI 650
SKKDVKLIQK NKRNFFERAV QNNFDLKTTT KIFSYIERFA NYGFNLSHAL 700
GYALLSYWTA WLKTNYPVYF YLWLLNHFQS SKDKQKLIIR TLEKSGIEIY 750
PPLLNKAQPN SVIENKKIYL GLNLIKGIND RYIQNLQKVQ HLIQTQNNLQ 800
LTDVVSWCLD KTIGDIPLKD LLLLKTMGCF DFFEYTYDFN DAKDFWIKSD 850
HLLFTRMPLE KKDSNFWIKQ FFTN 874
Length:874
Mass (Da):100,435
Last modified:November 1, 1996 - v1
Checksum:i9B27C96A28A74909
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71482.1.
PIRiH64228.
RefSeqiNP_072927.1. NC_000908.2.
WP_009885893.1. NZ_AAGX01000009.1.

Genome annotation databases

EnsemblBacteriaiAAC71482; AAC71482; MG_261.
GeneIDi875381.
KEGGimge:MG_261.
PATRICi20010020. VBIMycGen98045_0302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71482.1 .
PIRi H64228.
RefSeqi NP_072927.1. NC_000908.2.
WP_009885893.1. NZ_AAGX01000009.1.

3D structure databases

ProteinModelPortali Q49405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_261.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71482 ; AAC71482 ; MG_261 .
GeneIDi 875381.
KEGGi mge:MG_261.
PATRICi 20010020. VBIMycGen98045_0302.

Phylogenomic databases

eggNOGi COG0587.
KOi K02337.
OMAi ARINFIV.
OrthoDBi EOG6CZQGR.

Enzyme and pathway databases

BioCyci MGEN243273:GH2R-287-MONOMER.

Family and domain databases

InterProi IPR011708. DNA_pol3_alpha.
IPR004013. PHP_C.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
IPR004805. PolC_alpha.
[Graphical view ]
Pfami PF07733. DNA_pol3_alpha. 1 hit.
PF02811. PHP. 1 hit.
[Graphical view ]
SMARTi SM00481. POLIIIAc. 1 hit.
[Graphical view ]
SUPFAMi SSF89550. SSF89550. 1 hit.
TIGRFAMsi TIGR00594. polc. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiDPO3A_MYCGE
AccessioniPrimary (citable) accession number: Q49405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi