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Q49405

- DPO3A_MYCGE

UniProt

Q49405 - DPO3A_MYCGE

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Protein

DNA polymerase III subunit alpha

Gene

dnaE

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. 3'-5' exonuclease activity Source: InterPro
  2. DNA binding Source: InterPro
  3. DNA-directed DNA polymerase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-287-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit alpha (EC:2.7.7.7)
Gene namesi
Name:dnaE
Ordered Locus Names:MG261
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874DNA polymerase III subunit alphaPRO_0000103326Add
BLAST

Interactioni

Subunit structurei

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi243273.MG_261.

Structurei

3D structure databases

ProteinModelPortaliQ49405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0587.
KOiK02337.
OMAiARINFIV.
OrthoDBiEOG6CZQGR.

Family and domain databases

InterProiIPR011708. DNA_pol3_alpha.
IPR004013. PHP_C.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
IPR004805. PolC_alpha.
[Graphical view]
PfamiPF07733. DNA_pol3_alpha. 1 hit.
PF02811. PHP. 1 hit.
[Graphical view]
SMARTiSM00481. POLIIIAc. 1 hit.
[Graphical view]
SUPFAMiSSF89550. SSF89550. 1 hit.
TIGRFAMsiTIGR00594. polc. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49405-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFVNLHTNSY YNFLNSALSP KKLVNLAIND QQKAVAITDP NLFGAVEFFI
60 70 80 90 100
TCKQNNIKPI IGLNLTVEYQ KNDVKLLLIA KSNKGFQTLN KIALIQQKLE
110 120 130 140 150
INSLVDQLTD IAVIICSLTT WKSTYKDVYQ AKGIEINQTP IAILANAVNC
160 170 180 190 200
EKTNSDQVVL TVLKQMKQNQ TGKITTFDWD LKQKLNQISI NENLKVKSEI
210 220 230 240 250
QPFLDQKTAQ QLFSETELNN LNDLVNRCEL DLEHLKAASL SLTDNDAAVL
260 270 280 290 300
ESLCQTNLKQ FLDKNQDLNK KAYQLRLEKE LNVINKLNFA SYFLVVNDLV
310 320 330 340 350
NYAFKKDILI GSGRGSAVGS LVAFLLNITK IDPVQHQLIF ERFISTHRQD
360 370 380 390 400
LPDIDIDIME NKRAEMINYL FEKYGKENCA QIVTFQRFKT RSAVKEVAKL
410 420 430 440 450
FNDYGISDMI LGVLPKDQTI TFTDLKATED SALQLCLQQF GLIVELALAI
460 470 480 490 500
VDFPRQSSIH ASGIVIASNS LIKTIPLLQL DNNHFLTQVS MEWLSFFNLN
510 520 530 540 550
KFDLLGLINL TMISDVITQI KPSNQTVNQF LNTISWTDQN TFINLVNEDT
560 570 580 590 600
LGIFQLESFG MKKLLVQIKP KTINQLAIVL ALYRPGAQDN INLFINRLHN
610 620 630 640 650
GYDQSDIDPR ILPIVKNTYG VLIFQEQIIN IVKVVANYSL EEADSFRRAI
660 670 680 690 700
SKKDVKLIQK NKRNFFERAV QNNFDLKTTT KIFSYIERFA NYGFNLSHAL
710 720 730 740 750
GYALLSYWTA WLKTNYPVYF YLWLLNHFQS SKDKQKLIIR TLEKSGIEIY
760 770 780 790 800
PPLLNKAQPN SVIENKKIYL GLNLIKGIND RYIQNLQKVQ HLIQTQNNLQ
810 820 830 840 850
LTDVVSWCLD KTIGDIPLKD LLLLKTMGCF DFFEYTYDFN DAKDFWIKSD
860 870
HLLFTRMPLE KKDSNFWIKQ FFTN
Length:874
Mass (Da):100,435
Last modified:November 1, 1996 - v1
Checksum:i9B27C96A28A74909
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71482.1.
PIRiH64228.
RefSeqiNP_072927.1. NC_000908.2.
WP_009885893.1. NZ_AAGX01000009.1.

Genome annotation databases

EnsemblBacteriaiAAC71482; AAC71482; MG_261.
GeneIDi875381.
KEGGimge:MG_261.
PATRICi20010020. VBIMycGen98045_0302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71482.1 .
PIRi H64228.
RefSeqi NP_072927.1. NC_000908.2.
WP_009885893.1. NZ_AAGX01000009.1.

3D structure databases

ProteinModelPortali Q49405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_261.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71482 ; AAC71482 ; MG_261 .
GeneIDi 875381.
KEGGi mge:MG_261.
PATRICi 20010020. VBIMycGen98045_0302.

Phylogenomic databases

eggNOGi COG0587.
KOi K02337.
OMAi ARINFIV.
OrthoDBi EOG6CZQGR.

Enzyme and pathway databases

BioCyci MGEN243273:GH2R-287-MONOMER.

Family and domain databases

InterProi IPR011708. DNA_pol3_alpha.
IPR004013. PHP_C.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
IPR004805. PolC_alpha.
[Graphical view ]
Pfami PF07733. DNA_pol3_alpha. 1 hit.
PF02811. PHP. 1 hit.
[Graphical view ]
SMARTi SM00481. POLIIIAc. 1 hit.
[Graphical view ]
SUPFAMi SSF89550. SSF89550. 1 hit.
TIGRFAMsi TIGR00594. polc. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiDPO3A_MYCGE
AccessioniPrimary (citable) accession number: Q49405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3