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Protein

DNA polymerase III subunit alpha

Gene

dnaE

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-316-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit alpha (EC:2.7.7.7)
Gene namesi
Name:dnaE
Ordered Locus Names:MG261
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000807 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001033261 – 874DNA polymerase III subunit alphaAdd BLAST874

Proteomic databases

PRIDEiQ49405

Interactioni

Subunit structurei

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi243273.MgenG_010200002569

Structurei

3D structure databases

ProteinModelPortaliQ49405
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C0B Bacteria
COG0587 LUCA
KOiK02337
OMAiMMREYIL
OrthoDBiPOG091H02F7

Family and domain databases

InterProiView protein in InterPro
IPR011708 DNA_pol3_alpha
IPR004013 PHP_dom
IPR003141 Pol/His_phosphatase_N
IPR016195 Pol/histidinol_Pase-like
IPR004805 PolC_alpha
PANTHERiPTHR32294 PTHR32294, 2 hits
PfamiView protein in Pfam
PF07733 DNA_pol3_alpha, 1 hit
PF02811 PHP, 1 hit
SMARTiView protein in SMART
SM00481 POLIIIAc, 1 hit
SUPFAMiSSF89550 SSF89550, 1 hit
TIGRFAMsiTIGR00594 polc, 1 hit

Sequencei

Sequence statusi: Complete.

Q49405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVNLHTNSY YNFLNSALSP KKLVNLAIND QQKAVAITDP NLFGAVEFFI
60 70 80 90 100
TCKQNNIKPI IGLNLTVEYQ KNDVKLLLIA KSNKGFQTLN KIALIQQKLE
110 120 130 140 150
INSLVDQLTD IAVIICSLTT WKSTYKDVYQ AKGIEINQTP IAILANAVNC
160 170 180 190 200
EKTNSDQVVL TVLKQMKQNQ TGKITTFDWD LKQKLNQISI NENLKVKSEI
210 220 230 240 250
QPFLDQKTAQ QLFSETELNN LNDLVNRCEL DLEHLKAASL SLTDNDAAVL
260 270 280 290 300
ESLCQTNLKQ FLDKNQDLNK KAYQLRLEKE LNVINKLNFA SYFLVVNDLV
310 320 330 340 350
NYAFKKDILI GSGRGSAVGS LVAFLLNITK IDPVQHQLIF ERFISTHRQD
360 370 380 390 400
LPDIDIDIME NKRAEMINYL FEKYGKENCA QIVTFQRFKT RSAVKEVAKL
410 420 430 440 450
FNDYGISDMI LGVLPKDQTI TFTDLKATED SALQLCLQQF GLIVELALAI
460 470 480 490 500
VDFPRQSSIH ASGIVIASNS LIKTIPLLQL DNNHFLTQVS MEWLSFFNLN
510 520 530 540 550
KFDLLGLINL TMISDVITQI KPSNQTVNQF LNTISWTDQN TFINLVNEDT
560 570 580 590 600
LGIFQLESFG MKKLLVQIKP KTINQLAIVL ALYRPGAQDN INLFINRLHN
610 620 630 640 650
GYDQSDIDPR ILPIVKNTYG VLIFQEQIIN IVKVVANYSL EEADSFRRAI
660 670 680 690 700
SKKDVKLIQK NKRNFFERAV QNNFDLKTTT KIFSYIERFA NYGFNLSHAL
710 720 730 740 750
GYALLSYWTA WLKTNYPVYF YLWLLNHFQS SKDKQKLIIR TLEKSGIEIY
760 770 780 790 800
PPLLNKAQPN SVIENKKIYL GLNLIKGIND RYIQNLQKVQ HLIQTQNNLQ
810 820 830 840 850
LTDVVSWCLD KTIGDIPLKD LLLLKTMGCF DFFEYTYDFN DAKDFWIKSD
860 870
HLLFTRMPLE KKDSNFWIKQ FFTN
Length:874
Mass (Da):100,435
Last modified:November 1, 1996 - v1
Checksum:i9B27C96A28A74909
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71482.1
PIRiH64228
RefSeqiWP_009885893.1, NZ_AAGX01000009.1

Genome annotation databases

EnsemblBacteriaiAAC71482; AAC71482; MG_261
KEGGimge:MG_261

Similar proteinsi

Entry informationi

Entry nameiDPO3A_MYCGE
AccessioniPrimary (citable) accession number: Q49405
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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