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Q49405

- DPO3A_MYCGE

UniProt

Q49405 - DPO3A_MYCGE

Protein

DNA polymerase III subunit alpha

Gene

dnaE

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase By similarity.By similarity

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    GO - Molecular functioni

    1. 3'-5' exonuclease activity Source: InterPro
    2. DNA binding Source: InterPro
    3. DNA-directed DNA polymerase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-287-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase III subunit alpha (EC:2.7.7.7)
    Gene namesi
    Name:dnaE
    Ordered Locus Names:MG261
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 874874DNA polymerase III subunit alphaPRO_0000103326Add
    BLAST

    Interactioni

    Subunit structurei

    DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.By similarity

    Protein-protein interaction databases

    STRINGi243273.MG_261.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49405.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0587.
    KOiK02337.
    OMAiARINFIV.
    OrthoDBiEOG6CZQGR.

    Family and domain databases

    InterProiIPR011708. DNA_pol3_alpha.
    IPR004013. PHP_C.
    IPR003141. Pol/His_phosphatase_N.
    IPR016195. Pol/histidinol_Pase-like.
    IPR004805. PolC_alpha.
    [Graphical view]
    PfamiPF07733. DNA_pol3_alpha. 1 hit.
    PF02811. PHP. 1 hit.
    [Graphical view]
    SMARTiSM00481. POLIIIAc. 1 hit.
    [Graphical view]
    SUPFAMiSSF89550. SSF89550. 1 hit.
    TIGRFAMsiTIGR00594. polc. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q49405-1 [UniParc]FASTAAdd to Basket

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    MFVNLHTNSY YNFLNSALSP KKLVNLAIND QQKAVAITDP NLFGAVEFFI    50
    TCKQNNIKPI IGLNLTVEYQ KNDVKLLLIA KSNKGFQTLN KIALIQQKLE 100
    INSLVDQLTD IAVIICSLTT WKSTYKDVYQ AKGIEINQTP IAILANAVNC 150
    EKTNSDQVVL TVLKQMKQNQ TGKITTFDWD LKQKLNQISI NENLKVKSEI 200
    QPFLDQKTAQ QLFSETELNN LNDLVNRCEL DLEHLKAASL SLTDNDAAVL 250
    ESLCQTNLKQ FLDKNQDLNK KAYQLRLEKE LNVINKLNFA SYFLVVNDLV 300
    NYAFKKDILI GSGRGSAVGS LVAFLLNITK IDPVQHQLIF ERFISTHRQD 350
    LPDIDIDIME NKRAEMINYL FEKYGKENCA QIVTFQRFKT RSAVKEVAKL 400
    FNDYGISDMI LGVLPKDQTI TFTDLKATED SALQLCLQQF GLIVELALAI 450
    VDFPRQSSIH ASGIVIASNS LIKTIPLLQL DNNHFLTQVS MEWLSFFNLN 500
    KFDLLGLINL TMISDVITQI KPSNQTVNQF LNTISWTDQN TFINLVNEDT 550
    LGIFQLESFG MKKLLVQIKP KTINQLAIVL ALYRPGAQDN INLFINRLHN 600
    GYDQSDIDPR ILPIVKNTYG VLIFQEQIIN IVKVVANYSL EEADSFRRAI 650
    SKKDVKLIQK NKRNFFERAV QNNFDLKTTT KIFSYIERFA NYGFNLSHAL 700
    GYALLSYWTA WLKTNYPVYF YLWLLNHFQS SKDKQKLIIR TLEKSGIEIY 750
    PPLLNKAQPN SVIENKKIYL GLNLIKGIND RYIQNLQKVQ HLIQTQNNLQ 800
    LTDVVSWCLD KTIGDIPLKD LLLLKTMGCF DFFEYTYDFN DAKDFWIKSD 850
    HLLFTRMPLE KKDSNFWIKQ FFTN 874
    Length:874
    Mass (Da):100,435
    Last modified:November 1, 1996 - v1
    Checksum:i9B27C96A28A74909
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71482.1.
    PIRiH64228.
    RefSeqiNP_072927.1. NC_000908.2.
    WP_009885893.1. NZ_AAGX01000009.1.

    Genome annotation databases

    EnsemblBacteriaiAAC71482; AAC71482; MG_261.
    GeneIDi875381.
    KEGGimge:MG_261.
    PATRICi20010020. VBIMycGen98045_0302.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71482.1 .
    PIRi H64228.
    RefSeqi NP_072927.1. NC_000908.2.
    WP_009885893.1. NZ_AAGX01000009.1.

    3D structure databases

    ProteinModelPortali Q49405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_261.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71482 ; AAC71482 ; MG_261 .
    GeneIDi 875381.
    KEGGi mge:MG_261.
    PATRICi 20010020. VBIMycGen98045_0302.

    Phylogenomic databases

    eggNOGi COG0587.
    KOi K02337.
    OMAi ARINFIV.
    OrthoDBi EOG6CZQGR.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-287-MONOMER.

    Family and domain databases

    InterProi IPR011708. DNA_pol3_alpha.
    IPR004013. PHP_C.
    IPR003141. Pol/His_phosphatase_N.
    IPR016195. Pol/histidinol_Pase-like.
    IPR004805. PolC_alpha.
    [Graphical view ]
    Pfami PF07733. DNA_pol3_alpha. 1 hit.
    PF02811. PHP. 1 hit.
    [Graphical view ]
    SMARTi SM00481. POLIIIAc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89550. SSF89550. 1 hit.
    TIGRFAMsi TIGR00594. polc. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiDPO3A_MYCGE
    AccessioniPrimary (citable) accession number: Q49405
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3