ID   PLSC_MYCGE              Reviewed;         268 AA.
AC   Q49402; Q49287;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase;
DE            Short=1-AGP acyltransferase;
DE            Short=1-AGPAT;
DE            EC=2.3.1.51;
DE   AltName: Full=Lysophosphatidic acid acyltransferase;
DE            Short=LPAAT;
GN   Name=plsC; OrderedLocusNames=MG212;
OS   Mycoplasma genitalium.
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=2097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / G-37 / NCTC 10195;
RX   MEDLINE=96026346; PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-105.
RC   STRAIN=ATCC 33530 / G-37 / NCTC 10195;
RX   MEDLINE=94075230; PubMed=8253680;
RA   Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT   "A survey of the Mycoplasma genitalium genome by using random
RT   sequencing.";
RL   J. Bacteriol. 175:7918-7930(1993).
CC   -!- FUNCTION: Converts lysophosphatidic acid (LPA) into phosphatidic
CC       acid by incorporating acyl moiety at the 2 position.
CC   -!- CATALYTIC ACTIVITY: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate =
CC       CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis;
CC       CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
CC   -!- DOMAIN: The HXXXXD motif is essential for acyltransferase activity
CC       and may constitute the binding site for the phosphate moiety of
CC       the glycerol-3-phosphate (By similarity).
CC   -!- SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate
CC       acyltransferase family.
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DR   EMBL; L43967; AAC71431.1; -; Genomic_DNA.
DR   EMBL; U02160; AAD12442.1; -; Genomic_DNA.
DR   PIR; D64223; D64223.
DR   RefSeq; NP_072877.1; -.
DR   GeneID; 875333; -.
DR   GenomeReviews; L43967_GR; MG212.
DR   KEGG; mge:MG_212; -.
DR   TIGR; MG212; -.
DR   HOGENOM; Q49402; -.
DR   OMA; Q49402; GEFKSGA.
DR   BioCyc; MGEN243273:MG_212-MON; -.
DR   BRENDA; 2.3.1.51; 110.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0003841; F:1-acylglycerol-3-phosphate O-acyltransferas...; IEA:EC.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002123; Acyltransferase.
DR   InterPro; IPR004552; AGP_acyltrans.
DR   Pfam; PF01553; Acyltransferase; 1.
DR   SMART; SM00563; PlsC; 1.
DR   TIGRFAMs; TIGR00530; AGP_acyltrn; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Complete proteome; Phospholipid biosynthesis;
KW   Transferase.
FT   CHAIN         1    268       Probable 1-acyl-sn-glycerol-3-phosphate
FT                                acyltransferase.
FT                                /FTId=PRO_0000208172.
FT   MOTIF        92     97       HXXXXD motif.
FT   CONFLICT      2      2       Missing (in Ref. 2).
SQ   SEQUENCE   268 AA;  30469 MW;  A88B07D2BC4C6A4A CRC64;
     MDKLFKTSFR FIIRFLQILS LPVVFPYFLL SFLACLITSK NYESLPYNYP PEIRFKKVYR
     LVSMWLYIKG IKVVTVNDKI IPKKPVLVVA NHKSNLDPLV LIKAFGRLKN SPPLTFVAKI
     ELKDTVLFKL MKLIDCVFID RKNIRQIANA LETQQQLIRQ GTAIAVFAEG TRILSNDIGE
     FKPGALKVAY NAFVPILPVS IVGSLGKMES NKRLKEHGVK KSSNYEVKVI FNKLINPISF
     NQIDSNNLAN NIRSIISDAY TSEKPSND
//