Q49402 (PLSC_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
Short name=1-AGP acyltransferase
Short name=1-AGPAT
EC=2.3.1.51

Alternative name(s):
Lysophosphatidic acid acyltransferase
Short name=LPAAT

Gene names

Name:	plsC
Ordered Locus Names:	MG212

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.
Catalytic activity	Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Domain	The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.
Sequence similarities	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Molecular function	1-acylglycerol-3-phosphate O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase		PRO_0000208172
Regions
	Motif	92 – 97	6	HXXXXD motif
Experimental info
	Sequence conflict	2	1	Missing Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q49402 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A88B07D2BC4C6A4A	FASTA	268	30,469
	10 20 30 40 50 60 MDKLFKTSFR FIIRFLQILS LPVVFPYFLL SFLACLITSK NYESLPYNYP PEIRFKKVYR 70 80 90 100 110 120 LVSMWLYIKG IKVVTVNDKI IPKKPVLVVA NHKSNLDPLV LIKAFGRLKN SPPLTFVAKI 130 140 150 160 170 180 ELKDTVLFKL MKLIDCVFID RKNIRQIANA LETQQQLIRQ GTAIAVFAEG TRILSNDIGE 190 200 210 220 230 240 FKPGALKVAY NAFVPILPVS IVGSLGKMES NKRLKEHGVK KSSNYEVKVI FNKLINPISF 250 260 NQIDSNNLAN NIRSIISDAY TSEKPSND

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"A survey of the Mycoplasma genitalium genome by using random sequencing." Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III J. Bacteriol. 175:7918-7930(1993) [PubMed: 8253680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-105. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC71431.1. U02160 Genomic DNA. Translation: AAD12442.1.
PIR	D64223.
RefSeq	NP_072877.1. NC_000908.2.
3D structure databases
ProteinModelPortal	Q49402.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	875333.
GenomeReviews	Gene locus MG212 in contig L43967_GR.
KEGG	mge:MG_212.
PATRIC	20009884. VBIMycGen98045_0247.
TIGR	MG212.
Phylogenomic databases
HOGENOM	HBG571672.
OMA	GEFKSGA.
PhylomeDB	Q49402.
ProtClustDB	CLSK335198.
Enzyme and pathway databases
BioCyc	MGEN243273:MG_212-MONOMER.
Family and domain databases
InterPro	IPR002123. Acyltransferase. IPR004552. AGP_acyltrans. [Graphical view]
KO	K00655.
Pfam	PF01553. Acyltransferase. 1 hit. [Graphical view]
SMART	SM00563. PlsC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00530. AGP_acyltrn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PLSC_MYCGE

Accession

Primary (citable) accession number: Q49402
Secondary accession number(s): Q49287

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program