Reviewed, UniProtKB/Swiss-Prot Q493X8 (GCP_BLOPB)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	BPEN_060

Organism

Blochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]

Taxonomic identifier

291272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303283
Sites
	Metal binding	111	1	Zinc Potential
	Metal binding	115	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q493X8-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 246A35631B89E32B	FASTA	341	37,137
	10 20 30 40 50 60 MRVLGIETSC DETGVAIYDQ HKGLLANEVY SQSELHADYG GVVPELAARD HVRKIVPLIS 70 80 90 100 110 120 CTLNRARLEP KNIDGIAYTA GPGLMGALLV GATVARTLAY AWKIPAIDIH HMEAHLLAPM 130 140 150 160 170 180 LEKKVPTFPF IALLVSGGHT QLVSASNIGE YKILGESIDD AVGEVFDKIA ILLGLKYPGG 190 200 210 220 230 240 ALLSKMAQKG ISKRYVFPRP MIDRPGLNFS FSGLKTCTVN TIMSNSHDAQ NCADIARAFE 250 260 270 280 290 300 DAIIETLAIK CRRALNQTGL KCLVISGGVS ANHALRSYLL KMMYTLQGSL FYPRPEFCTD 310 320 330 340 NGAMVAYAGL IRLKAGLFSD LPILVRPRWS LEDLPRIKQS L

References

[1]	"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects." Degnan P.H., Lazarus A.B., Wernegreen J.J. Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000016 Genomic DNA. Translation: AAZ40706.1.
RefSeq	YP_277578.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q493X8.
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	3562953.
GenomeReviews	Gene locus BPEN_060 in contig CP000016_GR.
KEGG	bpn:BPEN_060.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q493X8.
OMA	CKRALKQ.
Enzyme and pathway databases
BioCyc	CBLO291272:BPEN_060-MON.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_BLOPB

Accession

Primary (citable) accession number: Q493X8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 13, 2005
Last modified:	November 3, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)