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Q493X5

- UPPP_BLOPB

UniProt

Q493X5 - UPPP_BLOPB

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Blochmannia pennsylvanicus (strain BPEN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBPEN291272:GJ9N-107-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA
    Ordered Locus Names:BPEN_063
    OrganismiBlochmannia pennsylvanicus (strain BPEN)
    Taxonomic identifieri291272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
    ProteomesiUP000007794: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294Undecaprenyl-diphosphatasePRO_0000227606Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi291272.BPEN_063.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221HelicalUniRule annotationAdd
    BLAST
    Transmembranei27 – 4721HelicalUniRule annotationAdd
    BLAST
    Transmembranei65 – 8521HelicalUniRule annotationAdd
    BLAST
    Transmembranei110 – 13021HelicalUniRule annotationAdd
    BLAST
    Transmembranei135 – 15521HelicalUniRule annotationAdd
    BLAST
    Transmembranei172 – 19221HelicalUniRule annotationAdd
    BLAST
    Transmembranei215 – 23521HelicalUniRule annotationAdd
    BLAST
    Transmembranei239 – 25921HelicalUniRule annotationAdd
    BLAST
    Transmembranei272 – 29221HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiWRKISSS.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q493X5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMIYITLNI IAYVIDVRSL ILDVRRLVFS LILGIVEGLT EFLPISSTGH    50
    MILVENILNC MDDSVIAFTV IIQLGAILSI TKIFWSQLYG MSMICIKKIF 100
    FKQHDDHNHL CIRHIFLGTF PGIMLGMIFY EKIGLIFELT YIMYGLIIGG 150
    IFLLVGELCA SKEPRVSRIN NITYLQAFLI GCFQCLAFWP GFSRAGATIG 200
    GGLVVGLDRR ISSEFSFFLA VPIIFGSAVL TLYHYRSCIG LMDVLLLIAG 250
    SATAFFIALF TVRYFLKIVK NVSLIPFAIY RFLLAGGIYW GLMT 294
    Length:294
    Mass (Da):32,957
    Last modified:September 13, 2005 - v1
    Checksum:i6B9786CB1A00CDFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000016 Genomic DNA. Translation: AAZ40709.1.
    RefSeqiWP_011282615.1. NC_007292.1.
    YP_277581.1. NC_007292.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ40709; AAZ40709; BPEN_063.
    GeneIDi3563147.
    KEGGibpn:BPEN_063.
    PATRICi31965010. VBICanBlo110049_0059.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000016 Genomic DNA. Translation: AAZ40709.1 .
    RefSeqi WP_011282615.1. NC_007292.1.
    YP_277581.1. NC_007292.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 291272.BPEN_063.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ40709 ; AAZ40709 ; BPEN_063 .
    GeneIDi 3563147.
    KEGGi bpn:BPEN_063.
    PATRICi 31965010. VBICanBlo110049_0059.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi WRKISSS.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci BPEN291272:GJ9N-107-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
      Degnan P.H., Lazarus A.B., Wernegreen J.J.
      Genome Res. 15:1023-1033(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BPEN.

    Entry informationi

    Entry nameiUPPP_BLOPB
    AccessioniPrimary (citable) accession number: Q493X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3