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Q493X5 (UPPP_BLOPB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA
Ordered Locus Names:BPEN_063
OrganismBlochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]
Taxonomic identifier291272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia ›

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000227606

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane27 – 4721Helical; Potential
Transmembrane65 – 8521Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane135 – 15521Helical; Potential
Transmembrane172 – 19221Helical; Potential
Transmembrane215 – 23521Helical; Potential
Transmembrane239 – 25921Helical; Potential
Transmembrane272 – 29221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q493X5 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 6B9786CB1A00CDFA

FASTA29432,957
        10         20         30         40         50         60 
MSMIYITLNI IAYVIDVRSL ILDVRRLVFS LILGIVEGLT EFLPISSTGH MILVENILNC 

        70         80         90        100        110        120 
MDDSVIAFTV IIQLGAILSI TKIFWSQLYG MSMICIKKIF FKQHDDHNHL CIRHIFLGTF 

       130        140        150        160        170        180 
PGIMLGMIFY EKIGLIFELT YIMYGLIIGG IFLLVGELCA SKEPRVSRIN NITYLQAFLI 

       190        200        210        220        230        240 
GCFQCLAFWP GFSRAGATIG GGLVVGLDRR ISSEFSFFLA VPIIFGSAVL TLYHYRSCIG 

       250        260        270        280        290 
LMDVLLLIAG SATAFFIALF TVRYFLKIVK NVSLIPFAIY RFLLAGGIYW GLMT

« Hide

References

[1]"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
Degnan P.H., Lazarus A.B., Wernegreen J.J.
Genome Res. 15:1023-1033(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BPEN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000016 Genomic DNA. Translation: AAZ40709.1.
RefSeqYP_277581.1. NC_007292.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING291272.BPEN_063.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ40709; AAZ40709; BPEN_063.
GeneID3563147.
KEGGbpn:BPEN_063.
PATRIC31965010. VBICanBlo110049_0059.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMARWLLRYI.

Enzyme and pathway databases

BioCycBPEN291272:GJ9N-107-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. Bacitracin-R_BacA.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_BLOPB
AccessionPrimary (citable) accession number: Q493X5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: September 13, 2005
Last modified: May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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