ID   KHSE_BLOPB              Reviewed;         312 AA.
AC   Q493S9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Homoserine kinase;
DE            Short=HSK;
DE            Short=HK;
DE            EC=2.7.1.39;
GN   Name=thrB; OrderedLocusNames=BPEN_116;
OS   Blochmannia pennsylvanicus (strain BPEN).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; ant endosymbionts; Candidatus Blochmannia.
OX   NCBI_TaxID=291272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16077009; DOI=10.1101/gr.3771305;
RA   Degnan P.H., Lazarus A.B., Wernegreen J.J.;
RT   "Genome sequence of Blochmannia pennsylvanicus indicates parallel
RT   evolutionary trends among bacterial mutualists of insects.";
RL   Genome Res. 15:1023-1033(2005).
CC   -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC       homoserine.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 4/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Homoserine kinase
CC       subfamily.
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DR   EMBL; CP000016; AAZ40756.1; -; Genomic_DNA.
DR   RefSeq; YP_277629.1; -.
DR   GeneID; 3563174; -.
DR   GenomeReviews; CP000016_GR; BPEN_116.
DR   KEGG; bpn:BPEN_116; -.
DR   HOGENOM; Q493S9; -.
DR   OMA; Q493S9; CGSAHAD.
DR   BioCyc; CBLO291272:BPEN_116-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:HAMAP.
DR   GO; GO:0016310; P:phosphorylation; IEA:InterPro.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00384; -; 1.
DR   InterPro; IPR006204; GHMP_kinase.
DR   InterPro; IPR013750; GHMP_kinase_C.
DR   InterPro; IPR006203; GHMP_knse_ATP_bd_CS.
DR   InterPro; IPR000870; Homoserine_kin.
DR   InterPro; IPR014721; Ribosomal_S5_D2-type_fold.
DR   Gene3D; G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000676; Homoser_kin; 1.
DR   PRINTS; PR00958; HOMSERKINASE.
DR   TIGRFAMs; TIGR00191; thrB; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm;
KW   Kinase; Nucleotide-binding; Threonine biosynthesis; Transferase.
FT   CHAIN         1    312       Homoserine kinase.
FT                                /FTId=PRO_1000049110.
FT   NP_BIND      91    101       ATP (Potential).
SQ   SEQUENCE   312 AA;  34526 MW;  9646B3521D58525D CRC64;
     MVRVYAPASI ANIGVGFDTL GMAIAPINGS LLGDCISIEH ANAFSLRSTG FFHSQLPIQL
     EENIVFQCWR KFCEILGQTY FLSIKLEKNI PVASGLGSSA CSIVAVLVAM NYHCGCPLNT
     DQLLMLMGEM EGKISGSIHF DNVSPCFLGG MRLILQNCNI VNQVIPSFDD WLWIVAYPGI
     KISTAVSRSV LPNKYDREDC INHSQYLSGF VHACHTKQEY LAIRCMKDII AEPYRSRLFP
     IELSCIRHNI MKRGAISCGI SGSGPTVFVL CNNHDVIGDI SDWLSRFYLQ NNSGFIRICS
     LDNLGARIMV NN
//