Q493S0 (DAPB_BLOPB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	BPEN_125

Organism

Blochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]

Taxonomic identifier

291272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subunit structure	Homotetramer By similarity. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000228329

Sequences

	Sequence		Length	Mass (Da)
	Q493S0 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 5309FAC65A17FA81	FASTA	282	30,864
	10 20 30 40 50 60 MSDTPLRIAV TGVTGRMGKE IVTCIVKEEK QFSQEIVLGA AITRLNTNIC GMDAGILINT 70 80 90 100 110 120 DALGIEITDN LESIKDNFDV LVDFTAPDIS IEYLKFCVNN NKNIVIGTTG FNQIHKNIIL 130 140 150 160 170 180 NASHKIGIVF SSNFSIGVAL ISKLLHKITQ VIGNTSDISI IETHHNRKRD IPSGTSLTMQ 190 200 210 220 230 240 NIIVNALRSI HSNRIIDSNL DSTTYSPASS YKDILIHSIR AGDVVGEHTV LFAGPGERLE 250 260 270 280 ITHKASDRLI FAHGALRAAF WVGRDKIGLF DISDILEMDT LL

References

[1]

"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects." Degnan P.H., Lazarus A.B., Wernegreen J.J. Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BPEN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000016 Genomic DNA. Translation: AAZ40765.1.
RefSeq	YP_277638.1. NC_007292.1.
3D structure databases
ProteinModelPortal	Q493S0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q493S0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3563160.
GenomeReviews	Gene locus BPEN_125 in contig CP000016_GR.
KEGG	bpn:BPEN_125.
PATRIC	31965141. VBICanBlo110049_0120.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0289.
HOGENOM	HBG594002.
OMA	YNNENIE.
PhylomeDB	Q493S0.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	CBLO291272:BPEN_125-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_BLOPB

Accession

Primary (citable) accession number: Q493S0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program