Reviewed, UniProtKB/Swiss-Prot Q493Q4 (MRAY_BLOPB)

Names and origin

Protein names

Recommended name:
    Phospho-N-acetylmuramoyl-pentapeptide-transferase
    EC=2.7.8.13
Alternative name(s):
    UDP-MurNAc-pentapeptide phosphotransferase

Gene names

Name:	mraY
Ordered Locus Names:	BPEN_143

Organism

Blochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]

Taxonomic identifier

291272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity.
Catalytic activity	UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 4 family. MraY subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	phospho-N-acetylmuramoyl-pentapeptide-transferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038		PRO_0000235438
Regions
	Transmembrane	28 – 48	21	Potential
	Transmembrane	72 – 92	21	Potential
	Transmembrane	94 – 114	21	Potential
	Transmembrane	131 – 151	21	Potential
	Transmembrane	169 – 189	21	Potential
	Transmembrane	200 – 220	21	Potential
	Transmembrane	236 – 256	21	Potential
	Transmembrane	264 – 284	21	Potential
	Transmembrane	290 – 310	21	Potential
	Transmembrane	339 – 359	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q493Q4-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 3E74709DE899D56F	FASTA	362	40,609
	10 20 30 40 50 60 MLFWLTENVL ALYSSRFNIV CHLTFRAIIS FLSALFISLG IGHCVITWFH NLCFFQIVRC 70 80 90 100 110 120 DGPKSHTQKQ STPTMGGIVL ILSIVISVMV CADLSNIYVW YVFFILITYG ILGLTDDILK 130 140 150 160 170 180 IKKKSSKGLS VLHKYFWQSL IALTLVIIIF MSDRSLTSTQ LIVPFFKNFM PQLGIWYIFL 190 200 210 220 230 240 AYFVVVGTSN AVNLSDGLDG LAIMPIMFVA AGLAVVAWIS NDIHFASHLN IPYICFSGEL 250 260 270 280 290 300 IIICSAIIGA GLGFLWFNTY PAQIFMGDVG SLSLGGTLGI IAVLLHQECL LLIMGGMFVI 310 320 330 340 350 360 ETLSVILQVI YFRLFGQRIF KMAPIHHHFE LKGCPEPRII VRFWIISLML VFVGLITLKI RQ

References

[1]	"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects." Degnan P.H., Lazarus A.B., Wernegreen J.J. Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000016 Genomic DNA. Translation: AAZ40783.1.
RefSeq	YP_277656.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q493Q4.
Genome annotation databases
GeneID	3562865.
GenomeReviews	Gene locus BPEN_143 in contig CP000016_GR.
KEGG	bpn:BPEN_143.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q493Q4.
OMA	HHHFEQK.
Enzyme and pathway databases
BioCyc	CBLO291272:BPEN_143-MON.
Family and domain databases
HAMAP	MF_00038. [Tree]
InterPro	IPR000715. Glycosyl_transferase_4. IPR018481. Glycosyl_Trfase_4_cons-reg. IPR003524. PNAcMuramoyl-5peptid_Trfase. IPR018480. PNAcMuramoyl-5peptid_Trfase_CS. [Graphical view]
PANTHER	PTHR22926. Glyco_trans_4. 1 hit. PTHR22926:SF3. PNAcPpept_trans. 1 hit.
Pfam	PF00953. Glycos_transf_4. 1 hit. PF10555. MraY_sig1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00445. mraY. 1 hit.
PROSITE	PS01347. MRAY_1. 1 hit. PS01348. MRAY_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MRAY_BLOPB

Accession

Primary (citable) accession number: Q493Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	September 13, 2005
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)