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Q493Q4 (MRAY_BLOPB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase

EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BPEN_143
OrganismBlochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]
Taxonomic identifier291272 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP-Rule MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP-Rule MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP-Rule MF_00038
PRO_0000235438

Regions

Transmembrane28 – 4821Helical; Potential
Transmembrane72 – 9221Helical; Potential
Transmembrane94 – 11421Helical; Potential
Transmembrane131 – 15121Helical; Potential
Transmembrane169 – 18921Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane236 – 25621Helical; Potential
Transmembrane264 – 28421Helical; Potential
Transmembrane290 – 31021Helical; Potential
Transmembrane339 – 35921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q493Q4 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 3E74709DE899D56F

FASTA36240,609
        10         20         30         40         50         60 
MLFWLTENVL ALYSSRFNIV CHLTFRAIIS FLSALFISLG IGHCVITWFH NLCFFQIVRC 

        70         80         90        100        110        120 
DGPKSHTQKQ STPTMGGIVL ILSIVISVMV CADLSNIYVW YVFFILITYG ILGLTDDILK 

       130        140        150        160        170        180 
IKKKSSKGLS VLHKYFWQSL IALTLVIIIF MSDRSLTSTQ LIVPFFKNFM PQLGIWYIFL 

       190        200        210        220        230        240 
AYFVVVGTSN AVNLSDGLDG LAIMPIMFVA AGLAVVAWIS NDIHFASHLN IPYICFSGEL 

       250        260        270        280        290        300 
IIICSAIIGA GLGFLWFNTY PAQIFMGDVG SLSLGGTLGI IAVLLHQECL LLIMGGMFVI 

       310        320        330        340        350        360 
ETLSVILQVI YFRLFGQRIF KMAPIHHHFE LKGCPEPRII VRFWIISLML VFVGLITLKI 


RQ 

« Hide

References

[1]"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
Degnan P.H., Lazarus A.B., Wernegreen J.J.
Genome Res. 15:1023-1033(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BPEN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000016 Genomic DNA. Translation: AAZ40783.1.
RefSeqYP_277656.1. NC_007292.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING291272.BPEN_143.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ40783; AAZ40783; BPEN_143.
GeneID3562865.
KEGGbpn:BPEN_143.
PATRIC31965177. VBICanBlo110049_0138.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHOG000275122.
KOK01000.
OMAHQNKKDT.
OrthoDBEOG69GZPZ.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

HAMAPMF_00038. MraY.
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERPTHR22926. PTHR22926. 1 hit.
PTHR22926:SF3. PTHR22926:SF3. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. mraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BLOPB
AccessionPrimary (citable) accession number: Q493Q4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: September 13, 2005
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways