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Q493Q4

- MRAY_BLOPB

UniProt

Q493Q4 - MRAY_BLOPB

Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Blochmannia pennsylvanicus (strain BPEN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

    Catalytic activityi

    UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. phospho-N-acetylmuramoyl-pentapeptide-transferase activity Source: UniProtKB-HAMAP
    2. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
    Alternative name(s):
    UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
    Gene namesi
    Name:mraYUniRule annotation
    Ordered Locus Names:BPEN_143
    OrganismiBlochmannia pennsylvanicus (strain BPEN)
    Taxonomic identifieri291272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
    ProteomesiUP000007794: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362Phospho-N-acetylmuramoyl-pentapeptide-transferasePRO_0000235438Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi291272.BPEN_143.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821HelicalUniRule annotationAdd
    BLAST
    Transmembranei72 – 9221HelicalUniRule annotationAdd
    BLAST
    Transmembranei94 – 11421HelicalUniRule annotationAdd
    BLAST
    Transmembranei131 – 15121HelicalUniRule annotationAdd
    BLAST
    Transmembranei169 – 18921HelicalUniRule annotationAdd
    BLAST
    Transmembranei200 – 22021HelicalUniRule annotationAdd
    BLAST
    Transmembranei236 – 25621HelicalUniRule annotationAdd
    BLAST
    Transmembranei264 – 28421HelicalUniRule annotationAdd
    BLAST
    Transmembranei290 – 31021HelicalUniRule annotationAdd
    BLAST
    Transmembranei339 – 35921HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0472.
    HOGENOMiHOG000275122.
    KOiK01000.
    OMAiQIHYVSG.
    OrthoDBiEOG69GZPZ.

    Family and domain databases

    HAMAPiMF_00038. MraY.
    InterProiIPR000715. Glycosyl_transferase_4.
    IPR003524. PNAcMuramoyl-5peptid_Trfase.
    IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
    [Graphical view]
    PANTHERiPTHR22926. PTHR22926. 1 hit.
    PfamiPF00953. Glycos_transf_4. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00445. mraY. 1 hit.
    PROSITEiPS01347. MRAY_1. 1 hit.
    PS01348. MRAY_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q493Q4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFWLTENVL ALYSSRFNIV CHLTFRAIIS FLSALFISLG IGHCVITWFH    50
    NLCFFQIVRC DGPKSHTQKQ STPTMGGIVL ILSIVISVMV CADLSNIYVW 100
    YVFFILITYG ILGLTDDILK IKKKSSKGLS VLHKYFWQSL IALTLVIIIF 150
    MSDRSLTSTQ LIVPFFKNFM PQLGIWYIFL AYFVVVGTSN AVNLSDGLDG 200
    LAIMPIMFVA AGLAVVAWIS NDIHFASHLN IPYICFSGEL IIICSAIIGA 250
    GLGFLWFNTY PAQIFMGDVG SLSLGGTLGI IAVLLHQECL LLIMGGMFVI 300
    ETLSVILQVI YFRLFGQRIF KMAPIHHHFE LKGCPEPRII VRFWIISLML 350
    VFVGLITLKI RQ 362
    Length:362
    Mass (Da):40,609
    Last modified:September 13, 2005 - v1
    Checksum:i3E74709DE899D56F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000016 Genomic DNA. Translation: AAZ40783.1.
    RefSeqiWP_011282690.1. NC_007292.1.
    YP_277656.1. NC_007292.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ40783; AAZ40783; BPEN_143.
    GeneIDi3562865.
    KEGGibpn:BPEN_143.
    PATRICi31965177. VBICanBlo110049_0138.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000016 Genomic DNA. Translation: AAZ40783.1 .
    RefSeqi WP_011282690.1. NC_007292.1.
    YP_277656.1. NC_007292.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 291272.BPEN_143.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ40783 ; AAZ40783 ; BPEN_143 .
    GeneIDi 3562865.
    KEGGi bpn:BPEN_143.
    PATRICi 31965177. VBICanBlo110049_0138.

    Phylogenomic databases

    eggNOGi COG0472.
    HOGENOMi HOG000275122.
    KOi K01000.
    OMAi QIHYVSG.
    OrthoDBi EOG69GZPZ.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .

    Family and domain databases

    HAMAPi MF_00038. MraY.
    InterProi IPR000715. Glycosyl_transferase_4.
    IPR003524. PNAcMuramoyl-5peptid_Trfase.
    IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
    [Graphical view ]
    PANTHERi PTHR22926. PTHR22926. 1 hit.
    Pfami PF00953. Glycos_transf_4. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00445. mraY. 1 hit.
    PROSITEi PS01347. MRAY_1. 1 hit.
    PS01348. MRAY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
      Degnan P.H., Lazarus A.B., Wernegreen J.J.
      Genome Res. 15:1023-1033(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BPEN.

    Entry informationi

    Entry nameiMRAY_BLOPB
    AccessioniPrimary (citable) accession number: Q493Q4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3