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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Blochmannia pennsylvanicus (strain BPEN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathway:ipeptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBPEN291272:GJ9N-249-MONOMER.
UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:BPEN_146
OrganismiBlochmannia pennsylvanicus (strain BPEN)
Taxonomic identifieri291272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
ProteomesiUP000007794 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferasePRO_0000225033Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi291272.BPEN_146.

Structurei

3D structure databases

ProteinModelPortaliQ493Q1.
SMRiQ493Q1. Positions 5-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0707.
HOGENOMiHOG000218321.
KOiK02563.
OMAiLHAHGPK.
OrthoDBiEOG61VZFD.

Family and domain databases

HAMAPiMF_00033. MurG.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q493Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQKKKIMIV AGGSGGHVFP GLSVAHYLIN HGYQVVWLGT ADRIESKLVP
60 70 80 90 100
QYGIDIKFIR INGWNGEKLH IKCIMPLFIC LAIYQARKII KYWKPDIVLG
110 120 130 140 150
MGGYVSGPGG LAAWTCGVPL IIHEQNRIIG LTNRYLSIFS KKVLQGFPGT
160 170 180 190 200
FPNAKMVGNP IRRAILAVPN PSRRWKGRVG PIRVLVIGGS QGAHILNKTI
210 220 230 240 250
PNMAEKLSDK LIIWHQVGEQ DFKKVIWAYQ KIKQSYHRIV KFIDDIAQAY
260 270 280 290 300
AWADILISRA GALTVSEVSI VGLPAIFVPF IHHKDRQQYW NAVPLVQAGA
310 320 330 340 350
AKIIEQKNFT SDVVSAMLES WDRKTLCSMA QRARSIAAPN ATQQVSQVII

EYLKK
Length:355
Mass (Da):39,653
Last modified:September 13, 2005 - v1
Checksum:i0476905013A04F68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000016 Genomic DNA. Translation: AAZ40786.1.
RefSeqiWP_011282693.1. NC_007292.1.

Genome annotation databases

EnsemblBacteriaiAAZ40786; AAZ40786; BPEN_146.
KEGGibpn:BPEN_146.
PATRICi31965183. VBICanBlo110049_0141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000016 Genomic DNA. Translation: AAZ40786.1.
RefSeqiWP_011282693.1. NC_007292.1.

3D structure databases

ProteinModelPortaliQ493Q1.
SMRiQ493Q1. Positions 5-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi291272.BPEN_146.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ40786; AAZ40786; BPEN_146.
KEGGibpn:BPEN_146.
PATRICi31965183. VBICanBlo110049_0141.

Phylogenomic databases

eggNOGiCOG0707.
HOGENOMiHOG000218321.
KOiK02563.
OMAiLHAHGPK.
OrthoDBiEOG61VZFD.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciBPEN291272:GJ9N-249-MONOMER.

Family and domain databases

HAMAPiMF_00033. MurG.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
    Degnan P.H., Lazarus A.B., Wernegreen J.J.
    Genome Res. 15:1023-1033(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BPEN.

Entry informationi

Entry nameiMURG_BLOPB
AccessioniPrimary (citable) accession number: Q493Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: July 22, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.