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Q493Q1

- MURG_BLOPB

UniProt

Q493Q1 - MURG_BLOPB

Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Blochmannia pennsylvanicus (strain BPEN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

    Catalytic activityi

    UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity Source: UniProtKB-EC
    3. undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. lipid glycosylation Source: UniProtKB-HAMAP
    4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    5. regulation of cell shape Source: UniProtKB-KW
    6. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBPEN291272:GJ9N-249-MONOMER.
    UniPathwayiUPA00219.

    Protein family/group databases

    CAZyiGT28. Glycosyltransferase Family 28.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
    Alternative name(s):
    Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
    Gene namesi
    Name:murGUniRule annotation
    Ordered Locus Names:BPEN_146
    OrganismiBlochmannia pennsylvanicus (strain BPEN)
    Taxonomic identifieri291272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
    ProteomesiUP000007794: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferasePRO_0000225033Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi291272.BPEN_146.

    Structurei

    3D structure databases

    ProteinModelPortaliQ493Q1.
    SMRiQ493Q1. Positions 5-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0707.
    HOGENOMiHOG000218321.
    KOiK02563.
    OMAiIFHESNA.
    OrthoDBiEOG61VZFD.

    Family and domain databases

    HAMAPiMF_00033. MurG.
    InterProiIPR006009. GlcNAc_MurG.
    IPR004276. Glyco_trans_28.
    IPR007235. Glyco_trans_28_C.
    [Graphical view]
    PfamiPF04101. Glyco_tran_28_C. 1 hit.
    PF03033. Glyco_transf_28. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01133. murG. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q493Q1-1 [UniParc]FASTAAdd to Basket

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    MNQKKKIMIV AGGSGGHVFP GLSVAHYLIN HGYQVVWLGT ADRIESKLVP    50
    QYGIDIKFIR INGWNGEKLH IKCIMPLFIC LAIYQARKII KYWKPDIVLG 100
    MGGYVSGPGG LAAWTCGVPL IIHEQNRIIG LTNRYLSIFS KKVLQGFPGT 150
    FPNAKMVGNP IRRAILAVPN PSRRWKGRVG PIRVLVIGGS QGAHILNKTI 200
    PNMAEKLSDK LIIWHQVGEQ DFKKVIWAYQ KIKQSYHRIV KFIDDIAQAY 250
    AWADILISRA GALTVSEVSI VGLPAIFVPF IHHKDRQQYW NAVPLVQAGA 300
    AKIIEQKNFT SDVVSAMLES WDRKTLCSMA QRARSIAAPN ATQQVSQVII 350
    EYLKK 355
    Length:355
    Mass (Da):39,653
    Last modified:September 13, 2005 - v1
    Checksum:i0476905013A04F68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000016 Genomic DNA. Translation: AAZ40786.1.
    RefSeqiYP_277659.1. NC_007292.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ40786; AAZ40786; BPEN_146.
    GeneIDi3562868.
    KEGGibpn:BPEN_146.
    PATRICi31965183. VBICanBlo110049_0141.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000016 Genomic DNA. Translation: AAZ40786.1 .
    RefSeqi YP_277659.1. NC_007292.1.

    3D structure databases

    ProteinModelPortali Q493Q1.
    SMRi Q493Q1. Positions 5-353.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 291272.BPEN_146.

    Protein family/group databases

    CAZyi GT28. Glycosyltransferase Family 28.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ40786 ; AAZ40786 ; BPEN_146 .
    GeneIDi 3562868.
    KEGGi bpn:BPEN_146.
    PATRICi 31965183. VBICanBlo110049_0141.

    Phylogenomic databases

    eggNOGi COG0707.
    HOGENOMi HOG000218321.
    KOi K02563.
    OMAi IFHESNA.
    OrthoDBi EOG61VZFD.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci BPEN291272:GJ9N-249-MONOMER.

    Family and domain databases

    HAMAPi MF_00033. MurG.
    InterProi IPR006009. GlcNAc_MurG.
    IPR004276. Glyco_trans_28.
    IPR007235. Glyco_trans_28_C.
    [Graphical view ]
    Pfami PF04101. Glyco_tran_28_C. 1 hit.
    PF03033. Glyco_transf_28. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01133. murG. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
      Degnan P.H., Lazarus A.B., Wernegreen J.J.
      Genome Res. 15:1023-1033(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BPEN.

    Entry informationi

    Entry nameiMURG_BLOPB
    AccessioniPrimary (citable) accession number: Q493Q1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3