Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q493Q1 (MURG_BLOPB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:BPEN_146
OrganismBlochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]
Taxonomic identifier291272 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP-Rule MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP-Rule MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00033

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP-Rule MF_00033
PRO_0000225033

Sequences

Sequence LengthMass (Da)Tools
Q493Q1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 0476905013A04F68

FASTA35539,653
        10         20         30         40         50         60 
MNQKKKIMIV AGGSGGHVFP GLSVAHYLIN HGYQVVWLGT ADRIESKLVP QYGIDIKFIR 

        70         80         90        100        110        120 
INGWNGEKLH IKCIMPLFIC LAIYQARKII KYWKPDIVLG MGGYVSGPGG LAAWTCGVPL 

       130        140        150        160        170        180 
IIHEQNRIIG LTNRYLSIFS KKVLQGFPGT FPNAKMVGNP IRRAILAVPN PSRRWKGRVG 

       190        200        210        220        230        240 
PIRVLVIGGS QGAHILNKTI PNMAEKLSDK LIIWHQVGEQ DFKKVIWAYQ KIKQSYHRIV 

       250        260        270        280        290        300 
KFIDDIAQAY AWADILISRA GALTVSEVSI VGLPAIFVPF IHHKDRQQYW NAVPLVQAGA 

       310        320        330        340        350 
AKIIEQKNFT SDVVSAMLES WDRKTLCSMA QRARSIAAPN ATQQVSQVII EYLKK 

« Hide

References

[1]"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
Degnan P.H., Lazarus A.B., Wernegreen J.J.
Genome Res. 15:1023-1033(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BPEN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000016 Genomic DNA. Translation: AAZ40786.1.
RefSeqYP_277659.1. NC_007292.1.

3D structure databases

ProteinModelPortalQ493Q1.
SMRQ493Q1. Positions 5-353.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING291272.BPEN_146.

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ40786; AAZ40786; BPEN_146.
GeneID3562868.
KEGGbpn:BPEN_146.
PATRIC31965183. VBICanBlo110049_0141.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0707.
HOGENOMHOG000218321.
KOK02563.
OMAIFHESNA.
OrthoDBEOG61VZFD.

Enzyme and pathway databases

BioCycBPEN291272:GJ9N-249-MONOMER.
UniPathwayUPA00219.

Family and domain databases

HAMAPMF_00033. MurG.
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. murG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_BLOPB
AccessionPrimary (citable) accession number: Q493Q1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways