Reviewed, UniProtKB/Swiss-Prot Q493Q0 (MURC_BLOPB)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylmuramate--L-alanine ligase
    EC=6.3.2.8
Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase

Gene names

Name:	murC
Ordered Locus Names:	BPEN_147

Organism

Blochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]

Taxonomic identifier

291272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation By similarity.
Catalytic activity	ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the murCDEF family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP UDP-N-acetylmuramate-L-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 480	480	UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046		PRO_0000242543
Regions
	Nucleotide binding	126 – 132	7	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q493Q0-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: F89F56671F27FCC6	FASTA	480	53,717
	10 20 30 40 50 60 MSGILLSNPV NAIPLMNRIR KIHFVGIGGT GMCGIAEILA HEGYCITGSD IVYSSTTRHL 70 80 90 100 110 120 FELGVKIFIG HKYSNINNAN VIVVSSAIHP NNPEILAAKQ ARIPVIKRAE MLSELMRFRH 130 140 150 160 170 180 GIAISGTHGK TTTTTMIVNI YTAAGLDPTF INGGIVKSEG VHARLGYSRY LIVEADESDN 190 200 210 220 230 240 SFLHLHPMVE VITNIDTDHI HEYQGNFEYL KKAFIDFLHN LPFYGYAIVC IDDPVICEIL 250 260 270 280 290 300 PKIKRKIITY GFNKNANLHI FNYRQHIEKS SFTVSRFNQT KLQVTLNAPG CHNALNATAA 310 320 330 340 350 360 IAVATEEGIS DKIILKTMLD FQGTHRRFEN LGYYSLNKIN DQTGEILLID DYGHHPAELH 370 380 390 400 410 420 ATIVAIRTGW PDRRLVMVFQ PHRYTRIKEL YYDFIDVLSN VDILLILHVY SAGEPPILGA 430 440 450 460 470 480 DSQSLCHAIR EFGKINPTFI SNTKMLSGAL FRLLRNNDLL LIQGAGTIGE VVRRLIVKND

References

[1]	"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects." Degnan P.H., Lazarus A.B., Wernegreen J.J. Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000016 Genomic DNA. Translation: AAZ40787.1.
RefSeq	YP_277660.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3562869.
GenomeReviews	Gene locus BPEN_147 in contig CP000016_GR.
KEGG	bpn:BPEN_147.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q493Q0.
OMA	Q493Q0. EWMVVEA.
Enzyme and pathway databases
BioCyc	CBLO291272:BPEN_147-MON.
Family and domain databases
HAMAP	MF_00046. [Tree]
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view]
Gene3D	G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
TIGRFAMs	TIGR01082. murC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURC_BLOPB

Accession

Primary (citable) accession number: Q493Q0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)