ID   TRMD_BLOPB              Reviewed;         255 AA.
AC   Q493M1;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=tRNA (guanine-N(1)-)-methyltransferase;
DE            EC=2.1.1.31;
DE   AltName: Full=M1G-methyltransferase;
DE   AltName: Full=tRNA [GM37] methyltransferase;
GN   Name=trmD; OrderedLocusNames=BPEN_181;
OS   Blochmannia pennsylvanicus (strain BPEN).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; ant endosymbionts; Candidatus Blochmannia.
OX   NCBI_TaxID=291272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16077009; DOI=10.1101/gr.3771305;
RA   Degnan P.H., Lazarus A.B., Wernegreen J.J.;
RT   "Genome sequence of Blochmannia pennsylvanicus indicates parallel
RT   evolutionary trends among bacterial mutualists of insects.";
RL   Genome Res. 15:1023-1033(2005).
CC   -!- FUNCTION: Specifically methylates guanosine-37 in various tRNAs
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-
CC       homocysteine + tRNA containing N(1)-methylguanine.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the RNA methyltransferase trmD family.
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DR   EMBL; CP000016; AAZ40819.1; -; Genomic_DNA.
DR   RefSeq; YP_277692.1; -.
DR   GeneID; 3562676; -.
DR   GenomeReviews; CP000016_GR; BPEN_181.
DR   KEGG; bpn:BPEN_181; -.
DR   HOGENOM; Q493M1; -.
DR   OMA; Q493M1; HRSVDDT.
DR   BioCyc; CBLO291272:BPEN_181-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0009019; F:tRNA (guanine-N1-)-methyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006400; P:tRNA modification; IEA:HAMAP.
DR   HAMAP; MF_00605; -; 1.
DR   InterPro; IPR016009; tRNA_m1G_MeTrfase.
DR   InterPro; IPR002649; tRNA_m1G_MeTrfase_bac.
DR   Pfam; PF01746; tRNA_m1G_MT; 1.
DR   PIRSF; PIRSF000386; tRNA_mtase; 1.
DR   ProDom; PD004978; tRNA_m1G_mtfrase; 1.
DR   TIGRFAMs; TIGR00088; trmD; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase;
KW   S-adenosyl-L-methionine; Transferase; tRNA processing.
FT   CHAIN         1    255       tRNA (guanine-N(1)-)-methyltransferase.
FT                                /FTId=PRO_0000257392.
FT   REGION      134    139       S-adenosyl-L-methionine binding (By
FT                                similarity).
FT   BINDING     114    114       S-adenosyl-L-methionine; via amide
FT                                nitrogen (By similarity).
SQ   SEQUENCE   255 AA;  29421 MW;  CE8090DD979E3E68 CRC64;
     MLLGVITLFP DMFQSIVRYG IVGRAIRRGI LSIKLWNPRL FTYDRHHSVD ARPYGGGPGM
     LMMIEPLRNA INQAKDELGN NIKVIYLSPQ GRKLKQKYVY KLAYDHQKLI LVCGRYQGID
     ERLIQTEIDE EWSIGDYILS GGELAAMVLI DTISRVLPGV LGNQDSKESD SFSKERLDCP
     HYTRPETFDG MKVPSVLLSG NHDEIHRWKQ KQALGRTWIK RPDLLNYIQL TNEEKNLLSE
     FKNEYLLSLN KKTRK
//