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Q493M1 (TRMD_BLOPB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
tRNA (guanine-N(1)-)-methyltransferase
EC=2.1.1.228
Alternative name(s):
M1G-methyltransferase
tRNA [GM37] methyltransferase
Gene names
Name:trmD
Ordered Locus Names:BPEN_181
OrganismBlochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]
Taxonomic identifier291272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates guanosine-37 in various tRNAs By similarity. HAMAP MF_00605

Catalytic activity

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA. HAMAP MF_00605

Subunit structure

Homodimer By similarity. HAMAP MF_00605

Subcellular location

Cytoplasm Potential HAMAP MF_00605.

Sequence similarities

Belongs to the RNA methyltransferase TrmD family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionRNA binding

Inferred from electronic annotation. Source: InterPro

tRNA (guanine-N1-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 255255tRNA (guanine-N(1)-)-methyltransferase HAMAP MF_00605
PRO_0000257392

Regions

Region134 – 1396S-adenosyl-L-methionine binding By similarity

Sites

Binding site1141S-adenosyl-L-methionine; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q493M1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: CE8090DD979E3E68

FASTA25529,421
        10         20         30         40         50         60 
MLLGVITLFP DMFQSIVRYG IVGRAIRRGI LSIKLWNPRL FTYDRHHSVD ARPYGGGPGM 

        70         80         90        100        110        120 
LMMIEPLRNA INQAKDELGN NIKVIYLSPQ GRKLKQKYVY KLAYDHQKLI LVCGRYQGID 

       130        140        150        160        170        180 
ERLIQTEIDE EWSIGDYILS GGELAAMVLI DTISRVLPGV LGNQDSKESD SFSKERLDCP 

       190        200        210        220        230        240 
HYTRPETFDG MKVPSVLLSG NHDEIHRWKQ KQALGRTWIK RPDLLNYIQL TNEEKNLLSE 

       250 
FKNEYLLSLN KKTRK

« Hide

References

[1]"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
Degnan P.H., Lazarus A.B., Wernegreen J.J.
Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BPEN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000016 Genomic DNA. Translation: AAZ40819.1.
RefSeqYP_277692.1. NC_007292.1.

3D structure databases

ProteinModelPortalQ493M1.
SMRQ493M1. Positions 1-245.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ493M1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3562676.
GenomeReviewsGene locus BPEN_181 in contig CP000016_GR.
KEGGbpn:BPEN_181.
PATRIC31965257. VBICanBlo110049_0176.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0336.
HOGENOMHBG285805.
OMANRYDLYL.
PhylomeDBQ493M1.
ProtClustDBPRK00026.

Enzyme and pathway databases

BioCycCBLO291272:BPEN_181-MONOMER.

Family and domain databases

HAMAPMF_00605. TrmD.
[Tree]
InterProIPR016009. tRNA_m1G_MeTrfase.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
[Graphical view]
Gene3DG3DSA:1.10.1270.20. tRNA_m1G_MeTrfase_C. 1 hit.
KOK00554.
PANTHERPTHR10056. PTHR10056. 1 hit.
PfamPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
PIRSFPIRSF000386. tRNA_mtase. 1 hit.
TIGRFAMsTIGR00088. TrmD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRMD_BLOPB
AccessionPrimary (citable) accession number: Q493M1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2005
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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