ID   AROE_BLOPB              Reviewed;         291 AA.
AC   Q493H9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 32.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=BPEN_228;
OS   Blochmannia pennsylvanicus (strain BPEN).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; ant endosymbionts; Candidatus Blochmannia.
OX   NCBI_TaxID=291272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16077009; DOI=10.1101/gr.3771305;
RA   Degnan P.H., Lazarus A.B., Wernegreen J.J.;
RT   "Genome sequence of Blochmannia pennsylvanicus indicates parallel
RT   evolutionary trends among bacterial mutualists of insects.";
RL   Genome Res. 15:1023-1033(2005).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; CP000016; AAZ40861.1; -; Genomic_DNA.
DR   RefSeq; YP_277734.1; -.
DR   GeneID; 3562942; -.
DR   GenomeReviews; CP000016_GR; BPEN_228.
DR   KEGG; bpn:BPEN_228; -.
DR   HOGENOM; Q493H9; -.
DR   OMA; Q493H9; YDMMYGR.
DR   BioCyc; CBLO291272:BPEN_228-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    291       Shikimate dehydrogenase.
FT                                /FTId=PRO_1000021266.
FT   NP_BIND     139    143       NADP (By similarity).
FT   ACT_SITE     65     65       Proton acceptor (Potential).
SQ   SEQUENCE   291 AA;  32769 MW;  858B148C01CF7D34 CRC64;
     MNSFAVFGNP IRHSKSAEIY ALFAHEIGIS KEYNLKLAVQ DNFNYLLHNF FKLGGLGANI
     TSPFKENAYF LCNQLTERAE KARSVNTIKK LKNGTLLGDN TDGIGFISDL KRLNWLDNNN
     QIISNDAPIP MVTNILLIGA GGAAKGIVPI LLTTITTCHI NIVNRTFSRA QELTSYYQEI
     GYKNISCLPL YKLRYDTNKY SLIINATTSN IHNTIPKIPY FLITPDTKCY DLFYTKQDTL
     FITWCKKNGA NYCADGLGML VGQAAHSFLL WHNTFPTINP VIDHLRSAFY M
//