Reviewed, UniProtKB/Swiss-Prot Q493H9 (AROE_BLOPB)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	BPEN_228

Organism

Blochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]

Taxonomic identifier

291272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021266
Regions
	Nucleotide binding	139 – 143	5	NADP By similarity
Sites
	Active site	65	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q493H9-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 858B148C01CF7D34	FASTA	291	32,769
	10 20 30 40 50 60 MNSFAVFGNP IRHSKSAEIY ALFAHEIGIS KEYNLKLAVQ DNFNYLLHNF FKLGGLGANI 70 80 90 100 110 120 TSPFKENAYF LCNQLTERAE KARSVNTIKK LKNGTLLGDN TDGIGFISDL KRLNWLDNNN 130 140 150 160 170 180 QIISNDAPIP MVTNILLIGA GGAAKGIVPI LLTTITTCHI NIVNRTFSRA QELTSYYQEI 190 200 210 220 230 240 GYKNISCLPL YKLRYDTNKY SLIINATTSN IHNTIPKIPY FLITPDTKCY DLFYTKQDTL 250 260 270 280 290 FITWCKKNGA NYCADGLGML VGQAAHSFLL WHNTFPTINP VIDHLRSAFY M

References

[1]	"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects." Degnan P.H., Lazarus A.B., Wernegreen J.J. Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000016 Genomic DNA. Translation: AAZ40861.1.
RefSeq	YP_277734.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3562942.
GenomeReviews	Gene locus BPEN_228 in contig CP000016_GR.
KEGG	bpn:BPEN_228.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q493H9.
OMA	Q493H9. YDMMYGR.
Enzyme and pathway databases
BioCyc	CBLO291272:BPEN_228-MON.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BLOPB

Accession

Primary (citable) accession number: Q493H9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)