Reviewed, UniProtKB/Swiss-Prot Q493C8 (DXR_BLOPB)

Names and origin

Protein names

Recommended name:
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
      Short name=DXP reductoisomerase
    EC=1.1.1.267
Alternative name(s):
    1-deoxyxylulose-5-phosphate reductoisomerase
    2-C-methyl-D-erythritol 4-phosphate synthase

Gene names

Name:	dxr
Ordered Locus Names:	BPEN_283

Organism

Blochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]

Taxonomic identifier

291272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity.
Catalytic activity	2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183
Cofactor	Divalent cation By similarity.
Pathway	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the DXR family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Ligand	Metal-binding NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183		PRO_1000020219
Regions
	Nucleotide binding	7 – 36	30	NADP By similarity
Sites
	Metal binding	151	1	Divalent metal cation By similarity
	Metal binding	153	1	Divalent metal cation By similarity
	Metal binding	232	1	Divalent metal cation By similarity
	Binding site	126	1	Substrate By similarity
	Binding site	153	1	Substrate By similarity
	Binding site	187	1	Substrate By similarity
	Binding site	210	1	Substrate By similarity
	Binding site	232	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q493C8-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: CBB38A687381B052	FASTA	397	43,728
	10 20 30 40 50 60 MQSLTILGST GSIGKATLSV IQQHTDKFFV HALVAKNNVA IMTEQCIAMS PKYACMISED 70 80 90 100 110 120 AARILKKNLI TAGKYDIEVL SGVMHACELA STNDVDMVMS AIVGIAGLKP TFSALRAGKK 130 140 150 160 170 180 ILLANKETLV TGGKLFMKEA NRYRACILPI DSEHNAIFQN LPEICQKSLG NTSLSECGIS 190 200 210 220 230 240 RIVLTASGGI FFKTPQKQLT KITPEQACVH PNWSMGRKIS VDSATMMNKG LEYIEARHLF 250 260 270 280 290 300 NAKPSEIEIL LHPQSIVHAM VYYSDGNVLA HLAPPDMRIP IAYAMAYPKR IGLKISSNID 310 320 330 340 350 360 IYYLNKLHFD QLDNCSYPCF QLAIDADNCS QSATIILNAA NEIAVEAFLR KMISFTDIPD 370 380 390 VIRRVLDAIN LNDPNDIEDI LYIDQKAREK AISICVI

References

[1]	"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects." Degnan P.H., Lazarus A.B., Wernegreen J.J. Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000016 Genomic DNA. Translation: AAZ40914.1.
RefSeq	YP_277787.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q493C8.
Genome annotation databases
GeneID	3562592.
GenomeReviews	Gene locus BPEN_283 in contig CP000016_GR.
KEGG	bpn:BPEN_283.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q493C8.
OMA	IHSMVEY.
Enzyme and pathway databases
BioCyc	CBLO291272:BPEN_283-MON.
Family and domain databases
HAMAP	MF_00183. [Tree]
InterPro	IPR003821. DXP_reductoisomerase. IPR013644. DXP_reductoisomerase_C. IPR013512. DXP_reductoisomerase_N. [Graphical view]
Pfam	PF08436. DXP_redisom_C. 1 hit. PF02670. DXP_reductoisom. 1 hit. [Graphical view]
PIRSF	PIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMs	TIGR00243. Dxr. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DXR_BLOPB

Accession

Primary (citable) accession number: Q493C8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 13, 2005
Last modified:	November 3, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)