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Q493B9

- LPXB_BLOPB

UniProt

Q493B9 - LPXB_BLOPB

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Blochmannia pennsylvanicus (strain BPEN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciBPEN291272:GJ9N-503-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:BPEN_292
    OrganismiBlochmannia pennsylvanicus (strain BPEN)
    Taxonomic identifieri291272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
    ProteomesiUP000007794: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 387387Lipid-A-disaccharide synthasePRO_0000255161Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi291272.BPEN_292.

    Structurei

    3D structure databases

    ProteinModelPortaliQ493B9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiEWTINPP.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q493B9-1 [UniParc]FASTAAdd to Basket

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    MSSIVPSMHN NRTIIIGIVA GEASGDILGA GLIRTLKKYL KKVRFFGIGG    50
    PCMQSEDMKS WYNIEELSVM GFAEIVMKLP RLLYIRRNLA RRFINLKPDV 100
    FIGIDSPDFN ISLENRLKKR GIRTIHYVSP SVWAWRKKRI FALKKATDNI 150
    LVILPFEKKI YDHFNIPCQF IGHSLADQIP LNPNKVSARQ KLGIPHDVYC 200
    LAVLPGSRIR EIKMLAHDFL VCAKLLKNNF PNLEILVPLT NQTSIKKFIS 250
    VASTSVKYRV LSNQSAWEIM MAADASLVTA GTATLECMLV KCPMVVAYRM 300
    HPLTFMLAKH FINIPWISLP NLLAGHELVK EFIQNNCRPE NLAQTLINLL 350
    NNNNQHIVLK KKFRQLHHSI RCNADEQAAY AVLRLIK 387
    Length:387
    Mass (Da):44,034
    Last modified:September 13, 2005 - v1
    Checksum:iB97761F9A2CFC254
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000016 Genomic DNA. Translation: AAZ40923.1.
    RefSeqiWP_011282830.1. NC_007292.1.
    YP_277796.1. NC_007292.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ40923; AAZ40923; BPEN_292.
    GeneIDi3562929.
    KEGGibpn:BPEN_292.
    PATRICi31965485. VBICanBlo110049_0284.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000016 Genomic DNA. Translation: AAZ40923.1 .
    RefSeqi WP_011282830.1. NC_007292.1.
    YP_277796.1. NC_007292.1.

    3D structure databases

    ProteinModelPortali Q493B9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 291272.BPEN_292.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ40923 ; AAZ40923 ; BPEN_292 .
    GeneIDi 3562929.
    KEGGi bpn:BPEN_292.
    PATRICi 31965485. VBICanBlo110049_0284.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi EWTINPP.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci BPEN291272:GJ9N-503-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
      Degnan P.H., Lazarus A.B., Wernegreen J.J.
      Genome Res. 15:1023-1033(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BPEN.

    Entry informationi

    Entry nameiLPXB_BLOPB
    AccessioniPrimary (citable) accession number: Q493B9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3