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Q493B9

- LPXB_BLOPB

UniProt

Q493B9 - LPXB_BLOPB

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, BPEN_292
Organism
Blochmannia pennsylvanicus (strain BPEN)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBPEN291272:GJ9N-503-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:BPEN_292
OrganismiBlochmannia pennsylvanicus (strain BPEN)
Taxonomic identifieri291272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
ProteomesiUP000007794: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000255161Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi291272.BPEN_292.

Structurei

3D structure databases

ProteinModelPortaliQ493B9.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiEWTINPP.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q493B9-1 [UniParc]FASTAAdd to Basket

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MSSIVPSMHN NRTIIIGIVA GEASGDILGA GLIRTLKKYL KKVRFFGIGG    50
PCMQSEDMKS WYNIEELSVM GFAEIVMKLP RLLYIRRNLA RRFINLKPDV 100
FIGIDSPDFN ISLENRLKKR GIRTIHYVSP SVWAWRKKRI FALKKATDNI 150
LVILPFEKKI YDHFNIPCQF IGHSLADQIP LNPNKVSARQ KLGIPHDVYC 200
LAVLPGSRIR EIKMLAHDFL VCAKLLKNNF PNLEILVPLT NQTSIKKFIS 250
VASTSVKYRV LSNQSAWEIM MAADASLVTA GTATLECMLV KCPMVVAYRM 300
HPLTFMLAKH FINIPWISLP NLLAGHELVK EFIQNNCRPE NLAQTLINLL 350
NNNNQHIVLK KKFRQLHHSI RCNADEQAAY AVLRLIK 387
Length:387
Mass (Da):44,034
Last modified:September 13, 2005 - v1
Checksum:iB97761F9A2CFC254
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000016 Genomic DNA. Translation: AAZ40923.1.
RefSeqiWP_011282830.1. NC_007292.1.
YP_277796.1. NC_007292.1.

Genome annotation databases

EnsemblBacteriaiAAZ40923; AAZ40923; BPEN_292.
GeneIDi3562929.
KEGGibpn:BPEN_292.
PATRICi31965485. VBICanBlo110049_0284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000016 Genomic DNA. Translation: AAZ40923.1 .
RefSeqi WP_011282830.1. NC_007292.1.
YP_277796.1. NC_007292.1.

3D structure databases

ProteinModelPortali Q493B9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 291272.BPEN_292.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ40923 ; AAZ40923 ; BPEN_292 .
GeneIDi 3562929.
KEGGi bpn:BPEN_292.
PATRICi 31965485. VBICanBlo110049_0284.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi EWTINPP.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci BPEN291272:GJ9N-503-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
    Degnan P.H., Lazarus A.B., Wernegreen J.J.
    Genome Res. 15:1023-1033(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BPEN.

Entry informationi

Entry nameiLPXB_BLOPB
AccessioniPrimary (citable) accession number: Q493B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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