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Q493B9 (LPXB_BLOPB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000255161

Sequences

Sequence LengthMass (Da)Tools
Q493B9 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: B97761F9A2CFC254

FASTA38744,034
        10         20         30         40         50         60 
MSSIVPSMHN NRTIIIGIVA GEASGDILGA GLIRTLKKYL KKVRFFGIGG PCMQSEDMKS 

        70         80         90        100        110        120 
WYNIEELSVM GFAEIVMKLP RLLYIRRNLA RRFINLKPDV FIGIDSPDFN ISLENRLKKR 

       130        140        150        160        170        180 
GIRTIHYVSP SVWAWRKKRI FALKKATDNI LVILPFEKKI YDHFNIPCQF IGHSLADQIP 

       190        200        210        220        230        240 
LNPNKVSARQ KLGIPHDVYC LAVLPGSRIR EIKMLAHDFL VCAKLLKNNF PNLEILVPLT 

       250        260        270        280        290        300 
NQTSIKKFIS VASTSVKYRV LSNQSAWEIM MAADASLVTA GTATLECMLV KCPMVVAYRM 

       310        320        330        340        350        360 
HPLTFMLAKH FINIPWISLP NLLAGHELVK EFIQNNCRPE NLAQTLINLL NNNNQHIVLK 

       370        380 
KKFRQLHHSI RCNADEQAAY AVLRLIK 

« Hide

References

[1]"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
Degnan P.H., Lazarus A.B., Wernegreen J.J.
Genome Res. 15:1023-1033(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BPEN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000016 Genomic DNA. Translation: AAZ40923.1.
RefSeqYP_277796.1. NC_007292.1.

3D structure databases

ProteinModelPortalQ493B9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING291272.BPEN_292.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ40923; AAZ40923; BPEN_292.
GeneID3562929.
KEGGbpn:BPEN_292.
PATRIC31965485. VBICanBlo110049_0284.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OMAYIAPQEW.
OrthoDBEOG6FBWZR.
ProtClustDBCLSK280787.

Enzyme and pathway databases

BioCycBPEN291272:GJ9N-503-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_BLOPB
AccessionPrimary (citable) accession number: Q493B9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2005
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways