Reviewed, UniProtKB/Swiss-Prot Q493B6 (ACCA_BLOPB)

Names and origin

Protein names

Recommended name:
    Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
      Short name=Acetyl-CoA carboxylase carboxyltransferase subunit alpha
      Short name=ACCase subunit alpha
    EC=6.4.1.2

Gene names

Name:	accA
Ordered Locus Names:	BPEN_295

Organism

Blochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]

Taxonomic identifier

291272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA By similarity.
Catalytic activity	ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. HAMAP MF_00823
Pathway	Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. HAMAP MF_00823
Subunit structure	Acetyl-CoA carboxylase is an heterohexamer composed of biotin carboxyl carrier protein (accB), biotin carboxylase (accC) and two subunits each of ACCase subunit alpha (accA) and ACCase subunit beta (accD) By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the accA family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	acetyl-CoA carboxylase complex Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetyl-CoA carboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha HAMAP MF_00823		PRO_0000223738

Sequences

	Sequence		Length	Mass (Da)
	Q493B6-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: DF6DC76AB1D01BA8	FASTA	319	35,643
	10 20 30 40 50 60 MGLNVLDFEK PILDLEEKIN SLTSIVHSDK KSKKNVNAEI NRLRSKSIEL TQKIFSNLNA 70 80 90 100 110 120 WQVAQLARHP RRPYTLDYIE RIFNDFDELS GDRVYADDKA IVGGIARLNS RPVMIIGHQK 130 140 150 160 170 180 GRDTKEKIKR NFGMSAPEGY RKALRLMKMA ERFKIPLITF IDTPGAYPGV GAEKRGQSAA 190 200 210 220 230 240 IAKNLRTMSI LKIPIICTVI GEGGSGGALA ISVGDKVNML EYSTYSVISP EGCASILWKN 250 260 270 280 290 300 VKKAPIAAEA MGITAYRLKE LNLIDSVISE PLGGAHRDIL TTSISLKTQL LLDLTELDSF 310 DEKELLNRRY QRLMHYGYC

References

[1]	"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects." Degnan P.H., Lazarus A.B., Wernegreen J.J. Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000016 Genomic DNA. Translation: AAZ40926.1.
RefSeq	YP_277799.1.
3D structure databases
SMR	Q493B6. Positions 19-318.
ModBase	Search...
Genome annotation databases
GeneID	3562840.
GenomeReviews	Gene locus BPEN_295 in contig CP000016_GR.
KEGG	bpn:BPEN_295.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q493B6.
OMA	Q493B6. HSVYTVA.
Enzyme and pathway databases
BioCyc	CBLO291272:BPEN_295-MON.
Family and domain databases
HAMAP	MF_00823. [Tree]
InterPro	IPR001095. Acetyl_CoA_COase_a_su. IPR011763. COA_CT_C. [Graphical view]
PANTHER	PTHR22855:SF3. Ac-CoA_carboxylA. 1 hit.
Pfam	PF03255. ACCA. 1 hit. [Graphical view]
PRINTS	PR01069. ACCCTRFRASEA.
TIGRFAMs	TIGR00513. accA. 1 hit.
PROSITE	PS50989. COA_CT_CTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACCA_BLOPB

Accession

Primary (citable) accession number: Q493B6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)