Reviewed, UniProtKB/Swiss-Prot Q493A5 (APT_BLOPB)

Names and origin

Protein names

Recommended name:
    Adenine phosphoribosyltransferase
      Short name=APRT
    EC=2.4.2.7

Gene names

Name:	apt
Ordered Locus Names:	BPEN_308

Organism

Blochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]

Taxonomic identifier

291272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	184 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity.
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: HAMAP purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 184	184	Adenine phosphoribosyltransferase HAMAP MF_00004		PRO_0000329336

Sequences

	Sequence		Length	Mass (Da)
	Q493A5-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: CA1EAD3C096E8DE0	FASTA	184	20,457
	10 20 30 40 50 60 MTNVTDQQLE LIKKSIQFVP NYPKKGILFR DITELLKNPQ AYSASITLLA YYYRNHKLTK 70 80 90 100 110 120 VVGIEARGFL FSAPLALILK LGFIPARKSG RLPRDTIREP YILEYDNGFL EIHTDSITPG 130 140 150 160 170 180 DQVLIIDDLL ATGGTIAAAV KLIRRLGGEV NHAGFIIDLE NLGGKSLLKE IGINSYSLVT FSNH

References

[1]	"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects." Degnan P.H., Lazarus A.B., Wernegreen J.J. Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000016 Genomic DNA. Translation: AAZ40939.1.
RefSeq	YP_277812.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q493A5.
Genome annotation databases
GeneID	3562585.
GenomeReviews	Gene locus BPEN_308 in contig CP000016_GR.
KEGG	bpn:BPEN_308.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q493A5.
OMA	KPGKLPA.
Enzyme and pathway databases
BioCyc	CBLO291272:BPEN_308-MON.
Family and domain databases
HAMAP	MF_00004. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR002375. Pr/py_Pribosyl_transf_CS. IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT_BLOPB

Accession

Primary (citable) accession number: Q493A5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	September 13, 2005
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)