Q49399 (Y146_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UPF0053 protein MG146

Alternative name(s):
VXpSPT7_orf424

Gene names

Ordered Locus Names:

MG146

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma genitalium

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the UPF0053 family. Contains 2 CBS domains. Contains 1 DUF21 domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	CBS domain Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 424	424	UPF0053 protein MG146		PRO_0000088378
Regions
	Transmembrane	7 – 27	21	Helical; Potential
	Transmembrane	71 – 91	21	Helical; Potential
	Transmembrane	101 – 121	21	Helical; Potential
	Transmembrane	135 – 155	21	Helical; Potential
	Domain	14 – 190	177	DUF21
	Domain	210 – 270	61	CBS 1
	Domain	272 – 332	61	CBS 2

Sequences

	Sequence		Length	Mass (Da)
	Q49399 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A361AAE5B995DA87	FASTA	424	48,720
	10 20 30 40 50 60 MDSAPSGLTL TVIILSIILL AFISTVVSAY ETAITSLTPY RWKNYIKTNN KQDKLSTKII 70 80 90 100 110 120 NHFQNHYSSC LITILITNNI VAIMVSNILF LALEQTIKNE LLSSVLNLVV SGVLIVSFCE 130 140 150 160 170 180 ILPKTLGRIN VIRTLVLFAY LVYFFYLIFW PITKLTSLIL KKYENPLPVS RKDVYYFIDE 190 200 210 220 230 240 IEQNGLFSKE DSLLIKKTLI FDQVLVKKVM IKWKKVAYCY LNDSINLIAK QFLQRQFSRM 250 260 270 280 290 300 PVVDKTTNKI VGFIHLKDFF TAKEANPKSL DLNQLLYPVV LVQDSTPIKQ ALRQMRLNRA 310 320 330 340 350 360 HLAVVNDKHE KTIGIVSMED IIEELVGEIY DEHDDIQPIQ VLDENVWLVL PNVKAAYFFN 370 380 390 400 410 420 KWIKPDLVKS KNITIQHYLA SLDNDSFACQ NKLDTPLFSV EVIADSEDKT KILYEIRKKS DVIA

References

[1]

"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC71364.1.
PIR	B64216.
RefSeq	NP_072808.1. NC_000908.2.
3D structure databases
ProteinModelPortal	Q49399.
ModBase	Search...
Protein-protein interaction databases
STRING	243273.MG_146.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC71364; AAC71364; MG_146.
GeneID	875520.
KEGG	mge:MG_146.
PATRIC	20009722. VBIMycGen98045_0167.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1253.
OMA	FFNKWIK.
ProtClustDB	CLSK336923.
Enzyme and pathway databases
BioCyc	MGEN243273:GH2R-189-MONOMER.
Family and domain databases
InterPro	IPR000644. Cysta_beta_synth_core. IPR002550. DUF21. [Graphical view]
Pfam	PF00571. CBS. 2 hits. PF01595. DUF21. 1 hit. [Graphical view]
SMART	SM00116. CBS. 2 hits. [Graphical view]
PROSITE	PS51371. CBS. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y146_MYCGE

Accession

Primary (citable) accession number: Q49399

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program