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Protein

UDP-galactopyranose mutase

Gene

glf

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the conversion of UDP-GalP into UDP-GalF through a 2-keto intermediate.By similarity

Catalytic activityi

UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311FADBy similarity
Binding sitei58 – 581FAD; via amide nitrogenBy similarity
Binding sitei176 – 1761UDP-GalPBy similarity
Binding sitei180 – 1801UDP-GalPBy similarity
Binding sitei205 – 2051UDP-GalPBy similarity
Binding sitei302 – 3021UDP-GalPBy similarity
Binding sitei311 – 3111UDP-GalPBy similarity
Binding sitei350 – 3501UDP-GalPBy similarity
Binding sitei379 – 3791FADBy similarity
Binding sitei385 – 3851UDP-GalPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 512FADBy similarity
Nucleotide bindingi77 – 782FADBy similarity
Nucleotide bindingi386 – 3916FADBy similarity

GO - Molecular functioni

  1. oxidoreductase activity Source: InterPro
  2. UDP-galactopyranose mutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-141-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-galactopyranose mutase (EC:5.4.99.9)
Short name:
UGM
Alternative name(s):
UDP-GALP mutase
Uridine 5-diphosphate galactopyranose mutase
Gene namesi
Name:glf
Ordered Locus Names:MG137
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404UDP-galactopyranose mutasePRO_0000087509Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243273.MG_137.

Structurei

3D structure databases

ProteinModelPortaliQ49398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0562.
KOiK01854.
OMAiEYPEAYE.
OrthoDBiEOG62K1X2.

Family and domain databases

Gene3Di3.40.50.720. 3 hits.
InterProiIPR016040. NAD(P)-bd_dom.
IPR003042. Rng_hydrolase-like.
IPR004379. UDP-GALP_mutase.
IPR015899. UDP-GalPyranose_mutase_C.
[Graphical view]
PANTHERiPTHR21197. PTHR21197. 1 hit.
PfamiPF03275. GLF. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.
TIGRFAMsiTIGR00031. UDP-GALP_mutase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49398-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVILSVMLF SSPSCVNINS FDILIVGAGI SGIVLANILA NHNKRVLIVE
60 70 80 90 100
KRDHIGGNCY DKVDSKTQLL FHQYGPHIFH TNNQTVINFI SPFFELNNYH
110 120 130 140 150
HRVGLKLKNN LDLTLPFDFQ QIYKLMGKDG RKLVSFFKEN FSLNTHLSLA
160 170 180 190 200
ELQLIDNPLA QKLYQFLISN VYKPYSVKMW GLPFAMINEN VINRVKIVLS
210 220 230 240 250
EQSSYFPDAI IQGLPKSGYT NSFLKMLANP LIDVQLNCKD NLLVYQDEKL
260 270 280 290 300
FFNNNLIEKP VVYCGLIDKL FNFCFGHLQY RSLAFSWKRF NQKKYQTYPV
310 320 330 340 350
VNMPLAKSIT RSVEYKQLTN QGSFKPQTIV SFETPGSYAI NDPRFNEPYY
360 370 380 390 400
PINNTLNDTL FKKYWKKASK LKNLHLLGRL ATYQYIDMDK AILLSIKKAQ

QLLS
Length:404
Mass (Da):46,661
Last modified:November 1, 1996 - v1
Checksum:i67B8DAB814A3A680
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71354.1.
PIRiB64215.
RefSeqiNP_072799.1. NC_000908.2.
WP_010869349.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71354; AAC71354; MG_137.
GeneIDi875453.
KEGGimge:MG_137.
PATRICi20009680. VBIMycGen98045_0149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71354.1.
PIRiB64215.
RefSeqiNP_072799.1. NC_000908.2.
WP_010869349.1. NC_000908.2.

3D structure databases

ProteinModelPortaliQ49398.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243273.MG_137.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC71354; AAC71354; MG_137.
GeneIDi875453.
KEGGimge:MG_137.
PATRICi20009680. VBIMycGen98045_0149.

Phylogenomic databases

eggNOGiCOG0562.
KOiK01854.
OMAiEYPEAYE.
OrthoDBiEOG62K1X2.

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-141-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 3 hits.
InterProiIPR016040. NAD(P)-bd_dom.
IPR003042. Rng_hydrolase-like.
IPR004379. UDP-GALP_mutase.
IPR015899. UDP-GalPyranose_mutase_C.
[Graphical view]
PANTHERiPTHR21197. PTHR21197. 1 hit.
PfamiPF03275. GLF. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.
TIGRFAMsiTIGR00031. UDP-GALP_mutase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiGLF_MYCGE
AccessioniPrimary (citable) accession number: Q49398
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.