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Q49398

- GLF_MYCGE

UniProt

Q49398 - GLF_MYCGE

Protein

UDP-galactopyranose mutase

Gene

glf

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Involved in the conversion of UDP-GalP into UDP-GalF through a 2-keto intermediate.By similarity

    Catalytic activityi

    UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose.

    Cofactori

    FAD.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei31 – 311FADBy similarity
    Binding sitei58 – 581FAD; via amide nitrogenBy similarity
    Binding sitei176 – 1761UDP-GalPBy similarity
    Binding sitei180 – 1801UDP-GalPBy similarity
    Binding sitei205 – 2051UDP-GalPBy similarity
    Binding sitei302 – 3021UDP-GalPBy similarity
    Binding sitei311 – 3111UDP-GalPBy similarity
    Binding sitei350 – 3501UDP-GalPBy similarity
    Binding sitei379 – 3791FADBy similarity
    Binding sitei385 – 3851UDP-GalPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi50 – 512FADBy similarity
    Nucleotide bindingi77 – 782FADBy similarity
    Nucleotide bindingi386 – 3916FADBy similarity

    GO - Molecular functioni

    1. oxidoreductase activity Source: InterPro
    2. UDP-galactopyranose mutase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-141-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-galactopyranose mutase (EC:5.4.99.9)
    Short name:
    UGM
    Alternative name(s):
    UDP-GALP mutase
    Uridine 5-diphosphate galactopyranose mutase
    Gene namesi
    Name:glf
    Ordered Locus Names:MG137
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404UDP-galactopyranose mutasePRO_0000087509Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243273.MG_137.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49398.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0562.
    KOiK01854.
    OMAiGKQWQTD.
    OrthoDBiEOG62K1X2.

    Family and domain databases

    Gene3Di3.40.50.720. 3 hits.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR003042. Rng_hydrolase-like.
    IPR004379. UDP-GALP_mutase.
    IPR015899. UDP-GalPyranose_mutase_C.
    [Graphical view]
    PANTHERiPTHR21197. PTHR21197. 1 hit.
    PfamiPF03275. GLF. 1 hit.
    [Graphical view]
    PRINTSiPR00420. RNGMNOXGNASE.
    TIGRFAMsiTIGR00031. UDP-GALP_mutase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q49398-1 [UniParc]FASTAAdd to Basket

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    MNVILSVMLF SSPSCVNINS FDILIVGAGI SGIVLANILA NHNKRVLIVE    50
    KRDHIGGNCY DKVDSKTQLL FHQYGPHIFH TNNQTVINFI SPFFELNNYH 100
    HRVGLKLKNN LDLTLPFDFQ QIYKLMGKDG RKLVSFFKEN FSLNTHLSLA 150
    ELQLIDNPLA QKLYQFLISN VYKPYSVKMW GLPFAMINEN VINRVKIVLS 200
    EQSSYFPDAI IQGLPKSGYT NSFLKMLANP LIDVQLNCKD NLLVYQDEKL 250
    FFNNNLIEKP VVYCGLIDKL FNFCFGHLQY RSLAFSWKRF NQKKYQTYPV 300
    VNMPLAKSIT RSVEYKQLTN QGSFKPQTIV SFETPGSYAI NDPRFNEPYY 350
    PINNTLNDTL FKKYWKKASK LKNLHLLGRL ATYQYIDMDK AILLSIKKAQ 400
    QLLS 404
    Length:404
    Mass (Da):46,661
    Last modified:November 1, 1996 - v1
    Checksum:i67B8DAB814A3A680
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71354.1.
    PIRiB64215.
    RefSeqiNP_072799.1. NC_000908.2.
    WP_010869349.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71354; AAC71354; MG_137.
    GeneIDi875453.
    KEGGimge:MG_137.
    PATRICi20009680. VBIMycGen98045_0149.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71354.1 .
    PIRi B64215.
    RefSeqi NP_072799.1. NC_000908.2.
    WP_010869349.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali Q49398.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_137.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71354 ; AAC71354 ; MG_137 .
    GeneIDi 875453.
    KEGGi mge:MG_137.
    PATRICi 20009680. VBIMycGen98045_0149.

    Phylogenomic databases

    eggNOGi COG0562.
    KOi K01854.
    OMAi GKQWQTD.
    OrthoDBi EOG62K1X2.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-141-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 3 hits.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR003042. Rng_hydrolase-like.
    IPR004379. UDP-GALP_mutase.
    IPR015899. UDP-GalPyranose_mutase_C.
    [Graphical view ]
    PANTHERi PTHR21197. PTHR21197. 1 hit.
    Pfami PF03275. GLF. 1 hit.
    [Graphical view ]
    PRINTSi PR00420. RNGMNOXGNASE.
    TIGRFAMsi TIGR00031. UDP-GALP_mutase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiGLF_MYCGE
    AccessioniPrimary (citable) accession number: Q49398
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3