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Protein

60 kDa chaperonin

Gene

groL

Organism
Mycobacterium gordonae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperonin
Alternative name(s):
65 kDa heat shock protein
GroEL protein
Protein Cpn60
Gene namesi
Name:groL
Synonyms:groEL, mopA
OrganismiMycobacterium gordonae
Taxonomic identifieri1778 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000063433‹1 – ›12060 kDa chaperoninAdd BLAST›120

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ49375
SMRiQ49375
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Family and domain databases

Gene3Di1.10.560.10, 1 hit
3.30.260.10, 1 hit
InterProiView protein in InterPro
IPR002423 Cpn60/TCP-1
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
SUPFAMiSSF48592 SSF48592, 1 hit

Sequencei

Sequence statusi: Fragment.

Q49375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PYEKIGAELV KEVAKKTDDV AGDGTTTATV LAQALVKEGL RNVAAGANPL
60 70 80 90 100
GLKRGIEKAV EKITQTLLSS AKDVETKEQI AATAGISAGD QSIGDLIAEA
110 120
MDKVGNEGVI TVEESNTFGL
Length:120
Mass (Da):12,325
Last modified:November 1, 1997 - v1
Checksum:i6AEA69474AC723E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1201

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti51G → A in strain: 85-736. 1
Natural varianti63I → V in strain: 85-736. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17933 Genomic DNA Translation: AAB39052.1
U17935 Genomic DNA Translation: AAB39054.1

Similar proteinsi

Entry informationi

Entry nameiCH60_MYCGO
AccessioniPrimary (citable) accession number: Q49375
Secondary accession number(s): Q49376
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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