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Protein

60 kDa chaperonin

Gene

groL

Organism
Mycobacterium genavense
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperonin
Alternative name(s):
65 kDa heat shock protein
GroEL protein
Protein Cpn60
Gene namesi
Name:groL
Synonyms:groEL, mopA
OrganismiMycobacterium genavense
Taxonomic identifieri36812 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000063431‹1 – ›12060 kDa chaperoninAdd BLAST›120

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ49374.
SMRiQ49374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Family and domain databases

Gene3Di1.10.560.10. 1 hit.
InterProiView protein in InterPro
IPR002423. Cpn60/TCP-1.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
SUPFAMiSSF48592. SSF48592. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q49374-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PYEKIGAELV KEVAKKTDDV AGDGTTTATV LAQALVKEGL RNVAAGANPL
60 70 80 90 100
GLKRGIEKAV EKITETLLKS AKDVETKEQI AATAAISAGD QSIGDLIAEA
110 120
MDKVGNEGVI TVEESNTFGL
Length:120
Mass (Da):12,381
Last modified:November 1, 1997 - v1
Checksum:i2EEA7D44EBF5277D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1201

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17932 Genomic DNA. Translation: AAB39051.1.

Similar proteinsi

Entry informationi

Entry nameiCH60_MYCGN
AccessioniPrimary (citable) accession number: Q49374
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 22, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families