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Q492Z3

- SYL_BLOPB

UniProt

Q492Z3 - SYL_BLOPB

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Blochmannia pennsylvanicus (strain BPEN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei634 – 6341ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BPEN_321
    OrganismiBlochmannia pennsylvanicus (strain BPEN)
    Taxonomic identifieri291272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
    ProteomesiUP000007794: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 872872Leucine--tRNA ligasePRO_1000009297Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi291272.BPEN_321.

    Structurei

    3D structure databases

    ProteinModelPortaliQ492Z3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi631 – 6355"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q492Z3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKSYSPSDI ESVVQKHWYK NKTFAVIEDS NKEKYYCLSM IPYPSGNLHM    50
    GHVRNYTIGD VISRYQRMLG KNVLQPIGWD AFGLPAEHAA IKNNTDPSIW 100
    TYSNINYMKS QLQSLGFAYD WNRELITCHP DYYRWEQWFF TVLYKKGLVY 150
    KKTASVNWCS YHKTVLANEQ VTNNCCWRCH TPVKYKRIPQ WFIRITNYAD 200
    QLLHGLDQLT HWPEQVKIMQ RNWIGRSKGV NVTFRIENSN DTLTIYMTRL 250
    DIFMGITYLV ISTDHPIALQ VAKTDLNVAH FIQKNDDFYT KLNKKNVFYF 300
    EKMGMPTHIY AIHPITNSKL PIWVANFVIP MECDGMGAAI SIPAHNQQDW 350
    EFAYKYNLPI KPVIKNLDAI EPNIAMQAQE TTCDGILFNS GEFDGLSSCT 400
    ASNAIVKSLI ARGVAQYKVN YRLKDWGISR QRYWGVPIPM VTLSNGVVKP 450
    VLLDRLPVIL PKNMSTIHRS NDGYVDNSLK MYPNWIQTTY KGQAAIRDTD 500
    TFDTFMESSW YYARYTCPRY NDAMLNVHAA NYWLPVDQYI GGIEHAIMHL 550
    LYFRFYHKLM RDEGLVYSDE PAIRLLCQGM VLADSFYYVS PNGQHIWVDP 600
    THVTIKRDRI GGIVKAIDKD GRDLIYDGMC KMSKSKNNGI DPNIIIEKYG 650
    ADAVRFFIMF AAPIEAPLEW KESGIEGAQR FLKRIWNLIY HHIQDGPVDA 700
    LSVVILNHAQ KFIRYNVHKT IEKVTDDIDR RQSFNTALSA IMKLVKKLYN 750
    APKTSMQDRA VLQEALLVIV RLLYPFTPHI SFILWKALGG SEDIDNATWP 800
    IVDTQAIQND RTLVLVQING KMRHKVFAPL NSDKNVVYKL LETEGVLNKY 850
    LIGKKINNII YVPNRVINII AK 872
    Length:872
    Mass (Da):100,838
    Last modified:September 13, 2005 - v1
    Checksum:iDDAEEB6764D24CFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000016 Genomic DNA. Translation: AAZ40951.1.
    RefSeqiYP_277824.1. NC_007292.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ40951; AAZ40951; BPEN_321.
    GeneIDi3562833.
    KEGGibpn:BPEN_321.
    PATRICi31965543. VBICanBlo110049_0312.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000016 Genomic DNA. Translation: AAZ40951.1 .
    RefSeqi YP_277824.1. NC_007292.1.

    3D structure databases

    ProteinModelPortali Q492Z3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 291272.BPEN_321.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ40951 ; AAZ40951 ; BPEN_321 .
    GeneIDi 3562833.
    KEGGi bpn:BPEN_321.
    PATRICi 31965543. VBICanBlo110049_0312.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
      Degnan P.H., Lazarus A.B., Wernegreen J.J.
      Genome Res. 15:1023-1033(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BPEN.

    Entry informationi

    Entry nameiSYL_BLOPB
    AccessioniPrimary (citable) accession number: Q492Z3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3