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Q492Z3

- SYL_BLOPB

UniProt

Q492Z3 - SYL_BLOPB

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Protein

Leucine--tRNA ligase

Gene
leuS, BPEN_321
Organism
Blochmannia pennsylvanicus (strain BPEN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei634 – 6341ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:BPEN_321
OrganismiBlochmannia pennsylvanicus (strain BPEN)
Taxonomic identifieri291272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
ProteomesiUP000007794: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 872872Leucine--tRNA ligaseUniRule annotationPRO_1000009297Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi291272.BPEN_321.

Structurei

3D structure databases

ProteinModelPortaliQ492Z3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi631 – 6355"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q492Z3-1 [UniParc]FASTAAdd to Basket

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MRKSYSPSDI ESVVQKHWYK NKTFAVIEDS NKEKYYCLSM IPYPSGNLHM    50
GHVRNYTIGD VISRYQRMLG KNVLQPIGWD AFGLPAEHAA IKNNTDPSIW 100
TYSNINYMKS QLQSLGFAYD WNRELITCHP DYYRWEQWFF TVLYKKGLVY 150
KKTASVNWCS YHKTVLANEQ VTNNCCWRCH TPVKYKRIPQ WFIRITNYAD 200
QLLHGLDQLT HWPEQVKIMQ RNWIGRSKGV NVTFRIENSN DTLTIYMTRL 250
DIFMGITYLV ISTDHPIALQ VAKTDLNVAH FIQKNDDFYT KLNKKNVFYF 300
EKMGMPTHIY AIHPITNSKL PIWVANFVIP MECDGMGAAI SIPAHNQQDW 350
EFAYKYNLPI KPVIKNLDAI EPNIAMQAQE TTCDGILFNS GEFDGLSSCT 400
ASNAIVKSLI ARGVAQYKVN YRLKDWGISR QRYWGVPIPM VTLSNGVVKP 450
VLLDRLPVIL PKNMSTIHRS NDGYVDNSLK MYPNWIQTTY KGQAAIRDTD 500
TFDTFMESSW YYARYTCPRY NDAMLNVHAA NYWLPVDQYI GGIEHAIMHL 550
LYFRFYHKLM RDEGLVYSDE PAIRLLCQGM VLADSFYYVS PNGQHIWVDP 600
THVTIKRDRI GGIVKAIDKD GRDLIYDGMC KMSKSKNNGI DPNIIIEKYG 650
ADAVRFFIMF AAPIEAPLEW KESGIEGAQR FLKRIWNLIY HHIQDGPVDA 700
LSVVILNHAQ KFIRYNVHKT IEKVTDDIDR RQSFNTALSA IMKLVKKLYN 750
APKTSMQDRA VLQEALLVIV RLLYPFTPHI SFILWKALGG SEDIDNATWP 800
IVDTQAIQND RTLVLVQING KMRHKVFAPL NSDKNVVYKL LETEGVLNKY 850
LIGKKINNII YVPNRVINII AK 872
Length:872
Mass (Da):100,838
Last modified:September 13, 2005 - v1
Checksum:iDDAEEB6764D24CFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000016 Genomic DNA. Translation: AAZ40951.1.
RefSeqiYP_277824.1. NC_007292.1.

Genome annotation databases

EnsemblBacteriaiAAZ40951; AAZ40951; BPEN_321.
GeneIDi3562833.
KEGGibpn:BPEN_321.
PATRICi31965543. VBICanBlo110049_0312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000016 Genomic DNA. Translation: AAZ40951.1 .
RefSeqi YP_277824.1. NC_007292.1.

3D structure databases

ProteinModelPortali Q492Z3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 291272.BPEN_321.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ40951 ; AAZ40951 ; BPEN_321 .
GeneIDi 3562833.
KEGGi bpn:BPEN_321.
PATRICi 31965543. VBICanBlo110049_0312.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
    Degnan P.H., Lazarus A.B., Wernegreen J.J.
    Genome Res. 15:1023-1033(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BPEN.

Entry informationi

Entry nameiSYL_BLOPB
AccessioniPrimary (citable) accession number: Q492Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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