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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Blochmannia pennsylvanicus (strain BPEN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyciCBLO291272:BPEN_RS01725-MONOMER
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:BPEN_351
OrganismiBlochmannia pennsylvanicus (strain BPEN)
Taxonomic identifieri291272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
Proteomesi
  • UP000007794 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002914641 – 3376-phosphogluconolactonaseAdd BLAST337

Proteomic databases

PRIDEiQ492W6

Interactioni

Protein-protein interaction databases

STRINGi291272.BPEN_351

Structurei

3D structure databases

ProteinModelPortaliQ492W6
SMRiQ492W6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105HHQ Bacteria
COG2706 LUCA
HOGENOMiHOG000257418
KOiK07404
OMAiEGNWPRD
OrthoDBiPOG091H07R3

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_01605 6P_gluconolactonase, 1 hit
InterProiView protein in InterPro
IPR022528 6-phosphogluconolactonase_YbhE
IPR019405 Lactonase_7-beta_prop
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit
SUPFAMiSSF50974 SSF50974, 1 hit

Sequencei

Sequence statusi: Complete.

Q492W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQIIYVASP ESQQIHVWKL DSIYGLLELI QVIYTHGQAQ PMAVHPNKRF
60 70 80 90 100
LYVGIRPNFG ITTYRIDQIG LLADHGTIGI FSSPTHLISD KKGAFLYCTS
110 120 130 140 150
YRNNTVSVIP ISMSGMLLDS PIQIIEGLLG CHSANIDKFK KLLWVPCLKE
160 170 180 190 200
NAIRLFNINS FGMLTSYDPS IIKINVGSGP RHMIFCDFDC YAYVINELTS
210 220 230 240 250
TVDVIKYNNF QKIPSIVQTV SIIPKNISIN RCWAADIHIT PNGRWLYCTD
260 270 280 290 300
RSINIISCLE ISKKTKKLKF VGYQLTEEQP RGFAIDYQGK FLVVAGQKSN
310 320 330
CISLYKIDSD NGTLTMLSRY SSGKGPMWVS IITLNCK
Length:337
Mass (Da):37,952
Last modified:September 13, 2005 - v1
Checksum:iC244FCF464675BF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000016 Genomic DNA Translation: AAZ40976.1
RefSeqiWP_011282885.1, NC_007292.1

Genome annotation databases

EnsemblBacteriaiAAZ40976; AAZ40976; BPEN_351
KEGGibpn:BPEN_351

Similar proteinsi

Entry informationi

Entry namei6PGL_BLOPB
AccessioniPrimary (citable) accession number: Q492W6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: September 13, 2005
Last modified: June 20, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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