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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Blochmannia pennsylvanicus (strain BPEN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathway: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:BPEN_351
OrganismiBlochmannia pennsylvanicus (strain BPEN)
Taxonomic identifieri291272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
ProteomesiUP000007794 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3373376-phosphogluconolactonasePRO_0000291464Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi291272.BPEN_351.

Structurei

3D structure databases

ProteinModelPortaliQ492W6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2706.
HOGENOMiHOG000257418.
KOiK07404.
OMAiYGYCVNE.
OrthoDBiEOG615VK7.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_01605. 6P_gluconolactonase.
InterProiIPR022528. 6-phosphogluconolactonase_YbhE.
IPR019405. Lactonase_7-beta_prop.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF10282. Lactonase. 1 hit.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.

Sequencei

Sequence statusi: Complete.

Q492W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQIIYVASP ESQQIHVWKL DSIYGLLELI QVIYTHGQAQ PMAVHPNKRF
60 70 80 90 100
LYVGIRPNFG ITTYRIDQIG LLADHGTIGI FSSPTHLISD KKGAFLYCTS
110 120 130 140 150
YRNNTVSVIP ISMSGMLLDS PIQIIEGLLG CHSANIDKFK KLLWVPCLKE
160 170 180 190 200
NAIRLFNINS FGMLTSYDPS IIKINVGSGP RHMIFCDFDC YAYVINELTS
210 220 230 240 250
TVDVIKYNNF QKIPSIVQTV SIIPKNISIN RCWAADIHIT PNGRWLYCTD
260 270 280 290 300
RSINIISCLE ISKKTKKLKF VGYQLTEEQP RGFAIDYQGK FLVVAGQKSN
310 320 330
CISLYKIDSD NGTLTMLSRY SSGKGPMWVS IITLNCK
Length:337
Mass (Da):37,952
Last modified:September 13, 2005 - v1
Checksum:iC244FCF464675BF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000016 Genomic DNA. Translation: AAZ40976.1.
RefSeqiWP_011282885.1. NC_007292.1.
YP_277851.1. NC_007292.1.

Genome annotation databases

EnsemblBacteriaiAAZ40976; AAZ40976; BPEN_351.
KEGGibpn:BPEN_351.
PATRICi31965603. VBICanBlo110049_0339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000016 Genomic DNA. Translation: AAZ40976.1.
RefSeqiWP_011282885.1. NC_007292.1.
YP_277851.1. NC_007292.1.

3D structure databases

ProteinModelPortaliQ492W6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi291272.BPEN_351.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ40976; AAZ40976; BPEN_351.
KEGGibpn:BPEN_351.
PATRICi31965603. VBICanBlo110049_0339.

Phylogenomic databases

eggNOGiCOG2706.
HOGENOMiHOG000257418.
KOiK07404.
OMAiYGYCVNE.
OrthoDBiEOG615VK7.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_01605. 6P_gluconolactonase.
InterProiIPR022528. 6-phosphogluconolactonase_YbhE.
IPR019405. Lactonase_7-beta_prop.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF10282. Lactonase. 1 hit.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
    Degnan P.H., Lazarus A.B., Wernegreen J.J.
    Genome Res. 15:1023-1033(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BPEN.

Entry informationi

Entry namei6PGL_BLOPB
AccessioniPrimary (citable) accession number: Q492W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: September 13, 2005
Last modified: May 27, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.